A novel hybrid metal nanomaterial, its preparation method and its application in matrix-assisted laser desorption ionization mass spectrometry

A technology of matrix-assisted laser and ionization mass spectrometry, applied in the application of matrix-assisted laser desorption ionization mass spectrometry, the field of new hybrid metal nanomaterials, can solve the problems of strong signal interference, achieve high sensitivity, simple synthesis method, and solve the Effects of background distractions and hotspot effects

Active Publication Date: 2022-04-29
SHANGHAI JIAOTONG UNIV
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In addition, considering the strong signal interference from nucleic acids, proteins and peptides when detected in real biological fluids, it is difficult to perform sensitive detection of low-abundance toxin molecules

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  • A novel hybrid metal nanomaterial, its preparation method and its application in matrix-assisted laser desorption ionization mass spectrometry
  • A novel hybrid metal nanomaterial, its preparation method and its application in matrix-assisted laser desorption ionization mass spectrometry
  • A novel hybrid metal nanomaterial, its preparation method and its application in matrix-assisted laser desorption ionization mass spectrometry

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[0039] The following describes several preferred embodiments of the present invention with reference to the accompanying drawings, so as to make the technical content clearer and easier to understand. The present invention can be embodied in many different forms of embodiments, and the protection scope of the present invention is not limited to the embodiments mentioned herein.

[0040] Prepare Fe-MOF hybrid nanoparticles wrapped by Pt nanoparticles as a matrix by layer-by-layer surface assembly method, including the following steps;

[0041]Step 1: Using the hydrothermal method, mix 5-10 g of fumaric acid and FeCl3 6H2O1-2 g in 100 mL of water, stir for 1 hour, and self-nucleate at 85 ° C for 16-24 hours to prepare monodisperse iron-based Metal-organic framework MIL-88A, expressed as MOFFe-MOF, is the core material;

[0042] Step 2: Add 0.2-0.4 g of PVP to the product obtained in Step 2 and stir at room temperature for 1-2 hours, and obtain the Fe-MOF@PVP composite as an int...

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Abstract

The invention discloses a preparation method of a novel hybrid metal nanomaterial, which is a Fe-MOF hybrid nano-particle wrapped by Pt nano-particles, which uses Pt nanoparticles as the outer shell and an iron-based metal-organic framework core material MIL-88A. Fe‑MOF hybrid nanoparticles are hybrid nanoparticles with the inner core. The invention also discloses a preparation method of the novel hybrid metal nanometer material and its application in matrix-assisted laser desorption ionization mass spectrometry. The Fe-MOF / Pt hybrid nanoparticle provided by the invention has a simple synthesis method and low material cost, and is suitable for large-scale industrial synthesis production. The core-shell metal nanomaterial matrix with controllable surface structure and hybrid composition is used as the matrix material in the mass spectrometer, which effectively solves the background interference and hot spot effect of the mass spectrogram of the small molecule segment (m / z<1000).

Description

technical field [0001] The invention relates to the field of chemical synthesis and application of micro-nano materials, in particular to a novel hybrid metal nano-material, its preparation method and its application in matrix-assisted laser desorption ionization mass spectrometry. Background technique [0002] The current detection methods for serum samples such as capillary electrophoresis analysis (CE), biochemical analysis (BCA) and enzyme-linked immunosorbent assay (ELISA) have unsatisfactory results. It takes a long time (BCA and ELISA detection methods react for about 30 minutes), requires cumbersome indirect detection (such as detection of enzymatic reaction products) or expensive reagents (such as labeled ELISA antibodies). Compared with these methods, mass spectrometry (MS) is capable of high-throughput extraction and measurement of molecular information (for example, liquid phase tandem mass spectrometry can accurately identify small molecules with mass error <...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/39G01N30/60
CPCG01N21/39G01N30/60
Inventor 钱昆刘寻黄琳
Owner SHANGHAI JIAOTONG UNIV
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