Sildenafil citrate chewable tablet and preparation method thereof

A technology of sildenafil citrate and chewable tablets, which is applied in the directions of non-active medical preparations, pharmaceutical formulations, organic non-active ingredients, etc., can solve the problems such as the way of taking patients that are not solved, and increase the storage stability. , Increase shelf life, good reproducibility

Active Publication Date: 2021-05-25
SHANGHAI PUKANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology only prepares sildenafil citrate tablets that disintegrate rapidly, and does not solve the problem of how patients take it.

Method used

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  • Sildenafil citrate chewable tablet and preparation method thereof
  • Sildenafil citrate chewable tablet and preparation method thereof
  • Sildenafil citrate chewable tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A kind of sildenafil citrate chewable tablet, the composition is as follows table 1:

[0044] Table 1 Example 1 Component Composition

[0045]

[0046] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:

[0047] (1) Grinding sildenafil citrate to particle size 090 ≤60um;

[0048] (2) Pulverizing sucrose and crossing 80 mesh sieves;

[0049] (3) Divide sucrose into 3 equal parts; mix sildenafil citrate with one part of sucrose, press, pulverize, and pass through a 30-mesh sieve to obtain primary granules, then take one part of sucrose and mix with primary granules, Squeeze, pulverize, and pass through a 30-mesh sieve to obtain secondary granules, then take a portion of sucrose and mix with the secondary granules, press, crush, and pass through a 30-mesh sieve to obtain tertiary granules, that is, sildenafil citrate-sucrose particles;

[0050] (4) Mix sildenafil citrate-sucrose granules with polyvinyl acetate, man...

Embodiment 2

[0052] A kind of sildenafil citrate chewable tablet, the composition is as follows table 2:

[0053] Table 2 embodiment 2 component composition

[0054]

[0055] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:

[0056] (1) Grinding sildenafil citrate to particle size 090 ≤60um;

[0057] (2) Pulverizing sucrose and crossing 80 mesh sieves;

[0058] (3) Divide sucrose into 5 equal parts; mix sildenafil citrate with one part of sucrose, press, crush, and pass through a 30-mesh sieve to obtain primary granules, then take one part of sucrose and mix with primary granules, Squeeze, pulverize, and pass through a 30-mesh sieve to obtain secondary granules, then take a portion of sucrose and mix with the secondary granules, press, crush, and pass through a 30-mesh sieve to obtain three granules, repeat 5 times to obtain Citron Sildenafil Acid-Sucrose Granules;

[0059] (4) Mix sildenafil citrate-sucrose granules with xylitol, ...

Embodiment 3

[0061] A kind of sildenafil citrate chewable tablet, the composition is as follows table 3:

[0062] Table 3 embodiment 3 component composition

[0063]

[0064] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:

[0065] (1) Grinding sildenafil citrate to particle size 090 ≤60um;

[0066] (2) Pulverizing the sucrose and passing through a 100-mesh sieve;

[0067] (3) Mix the sucrose and sucralose evenly and divide them into 3 equal parts of mixed sucrose; mix sildenafil citrate with one part of mixed sucrose, press, pulverize, and pass through a 40-mesh sieve to obtain primary granules, Take another part of mixed sucrose and mix with the primary granules, press, crush, and pass through a 40-mesh sieve to obtain secondary granules, and then take another part of mixed sucrose and mix with the secondary granules, press, crush, and pass through a 40-mesh sieve to obtain three times Granules, namely sildenafil citrate-mixed ...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a sildenafil citrate chewable tablet and a preparation method thereof. The sildenafil citrate chewable tablet is prepared from sildenafil citrate, a filling agent, an excipient, a sweetening agent, a lubricating agent and a compound flavoring agent. According to the invention, dry granulation is carried out for many times, so that the taste of sildenafil citrate is covered; the medicine can be taken without water, and the patient compliance is high; meanwhile, the storage stability of the sildenafil citrate chewable tablet can be effectively improved.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a sildenafil citrate chewable tablet and a preparation method thereof. Background technique [0002] Sildenafil citrate is a drug for the treatment of male penile erectile dysfunction. Its main function is to dilate blood vessels, improve blood flow to target organs and reduce pulmonary hypertension. It is mainly used to improve male erectile dysfunction and to treat patients with pulmonary arterial hypertension. It is currently the drug of choice for clinical treatment of various types of erectile dysfunction. The recommended dose is 50mg, and the daily dose is 25-100mg. At the same time, sildenafil citrate has a slight effect of dilating the coronary arteries, so if patients with coronary heart disease also have male erectile dysfunction, it cannot be taken together with the drugs that expand the coronary arteries. This can lead to persistent hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/519A61K47/10A61K47/08A61K47/12A61K47/24A61P15/10A61P9/12
CPCA61K9/0056A61K9/2013A61K9/2095A61K31/519A61K47/08A61K47/10A61K47/12A61K47/24A61P9/12A61P15/10
Inventor 张用杰赵颖
Owner SHANGHAI PUKANG PHARMA
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