Sildenafil citrate chewable tablet and preparation method thereof
A technology of sildenafil citrate and chewable tablets, which is applied in the directions of non-active medical preparations, pharmaceutical formulations, organic non-active ingredients, etc., can solve the problems such as the way of taking patients that are not solved, and increase the storage stability. , Increase shelf life, good reproducibility
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Embodiment 1
[0043] A kind of sildenafil citrate chewable tablet, the composition is as follows table 1:
[0044] Table 1 Example 1 Component Composition
[0045]
[0046] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:
[0047] (1) Grinding sildenafil citrate to particle size 090 ≤60um;
[0048] (2) Pulverizing sucrose and crossing 80 mesh sieves;
[0049] (3) Divide sucrose into 3 equal parts; mix sildenafil citrate with one part of sucrose, press, pulverize, and pass through a 30-mesh sieve to obtain primary granules, then take one part of sucrose and mix with primary granules, Squeeze, pulverize, and pass through a 30-mesh sieve to obtain secondary granules, then take a portion of sucrose and mix with the secondary granules, press, crush, and pass through a 30-mesh sieve to obtain tertiary granules, that is, sildenafil citrate-sucrose particles;
[0050] (4) Mix sildenafil citrate-sucrose granules with polyvinyl acetate, man...
Embodiment 2
[0052] A kind of sildenafil citrate chewable tablet, the composition is as follows table 2:
[0053] Table 2 embodiment 2 component composition
[0054]
[0055] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:
[0056] (1) Grinding sildenafil citrate to particle size 090 ≤60um;
[0057] (2) Pulverizing sucrose and crossing 80 mesh sieves;
[0058] (3) Divide sucrose into 5 equal parts; mix sildenafil citrate with one part of sucrose, press, crush, and pass through a 30-mesh sieve to obtain primary granules, then take one part of sucrose and mix with primary granules, Squeeze, pulverize, and pass through a 30-mesh sieve to obtain secondary granules, then take a portion of sucrose and mix with the secondary granules, press, crush, and pass through a 30-mesh sieve to obtain three granules, repeat 5 times to obtain Citron Sildenafil Acid-Sucrose Granules;
[0059] (4) Mix sildenafil citrate-sucrose granules with xylitol, ...
Embodiment 3
[0061] A kind of sildenafil citrate chewable tablet, the composition is as follows table 3:
[0062] Table 3 embodiment 3 component composition
[0063]
[0064] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:
[0065] (1) Grinding sildenafil citrate to particle size 090 ≤60um;
[0066] (2) Pulverizing the sucrose and passing through a 100-mesh sieve;
[0067] (3) Mix the sucrose and sucralose evenly and divide them into 3 equal parts of mixed sucrose; mix sildenafil citrate with one part of mixed sucrose, press, pulverize, and pass through a 40-mesh sieve to obtain primary granules, Take another part of mixed sucrose and mix with the primary granules, press, crush, and pass through a 40-mesh sieve to obtain secondary granules, and then take another part of mixed sucrose and mix with the secondary granules, press, crush, and pass through a 40-mesh sieve to obtain three times Granules, namely sildenafil citrate-mixed ...
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