The invention discloses a metformin hydrochloride sustained-release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. The metformin hydrochloride sustained-release tablet comprises metformin hydrochloride, a sustained-release agent, an adhesive, filler, a flow aid, a lubricant and other components, wherein the sustained-release agent comprises sodium carboxymethyl cellulose and hydroxypropyl methyl cellulose K100M, the adhesive is hydroxypropyl methyl cellulose E5, and the ratio of the metformin hydrochloride to the sustained-release agent is 125:(80-120); and the ratio of the metformin hydrochloride to the adhesive is 125:(1.5-3.0), and the preparation process comprises the steps: spraying water, mixing the metformin hydrochloridewith sodium carboxymethyl cellulose, performing granulation so as to obtain particles, performing secondary water spraying, and adding hydroxypropyl methyl cellulose K100M at twice. The method is suitable for industrial production, the product quality is stable, and the obtained metformin hydrochloride sustained-release tablet has uniform and stable release.