A kind of sildenafil citrate chewable tablet and preparation method thereof
A technology of sildenafil citrate and chewable tablets, which is applied in the directions of inactive medical preparations, pharmaceutical formulations, organic inactive ingredients, etc., can solve problems such as the way that patients are not taken, and achieve increased storage stability. , Increase shelf life, good reproducibility
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Embodiment 1
[0043] A kind of sildenafil citrate chewable tablet, the composition is as follows table 1:
[0044] Table 1 Example 1 Component Composition
[0045]
[0046] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:
[0047] (1) Grinding sildenafil citrate to particle size 090 ≤60um;
[0048] (2) Pulverizing sucrose and crossing 80 mesh sieves;
[0049] (3) Divide sucrose into 3 equal parts; mix sildenafil citrate with one part of sucrose, press, pulverize, and pass through a 30-mesh sieve to obtain primary granules, then take one part of sucrose and mix with primary granules, Squeeze, pulverize, and pass through a 30-mesh sieve to obtain secondary granules, then take a portion of sucrose and mix with the secondary granules, press, crush, and pass through a 30-mesh sieve to obtain tertiary granules, that is, sildenafil citrate-sucrose particles;
[0050] (4) Mix sildenafil citrate-sucrose granules with polyvinyl acetate, man...
Embodiment 2
[0052] A kind of sildenafil citrate chewable tablet, the composition is as follows table 2:
[0053] Table 2 embodiment 2 component composition
[0054]
[0055] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:
[0056] (1) Grinding sildenafil citrate to particle size 090 ≤60um;
[0057] (2) Pulverizing sucrose and crossing 80 mesh sieves;
[0058] (3) Divide sucrose into 5 equal parts; mix sildenafil citrate with one part of sucrose, press, crush, and pass through a 30-mesh sieve to obtain primary granules, then take one part of sucrose and mix with primary granules, Squeeze, pulverize, and pass through a 30-mesh sieve to obtain secondary granules, then take a portion of sucrose and mix with the secondary granules, press, crush, and pass through a 30-mesh sieve to obtain three granules, repeat 5 times to obtain Citron Sildenafil Acid-Sucrose Granules;
[0059] (4) Mix sildenafil citrate-sucrose granules with xylitol, ...
Embodiment 3
[0061] A kind of sildenafil citrate chewable tablet, the composition is as follows table 3:
[0062] Table 3 embodiment 3 component composition
[0063]
[0064] The preparation method of described sildenafil citrate chewable tablet, comprises the following steps:
[0065] (1) Grinding sildenafil citrate to particle size 090 ≤60um;
[0066] (2) Pulverizing the sucrose and passing through a 100-mesh sieve;
[0067] (3) Mix the sucrose and sucralose evenly and divide them into 3 equal parts of mixed sucrose; mix sildenafil citrate with one part of mixed sucrose, press, pulverize, and pass through a 40-mesh sieve to obtain primary granules, Take another part of mixed sucrose and mix with the primary granules, press, crush, and pass through a 40-mesh sieve to obtain secondary granules, and then take another part of mixed sucrose and mix with the secondary granules, press, crush, and pass through a 40-mesh sieve to obtain three times Granules, namely sildenafil citrate-mixed ...
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