Abiraterone acetate pharmaceutical composition, preparation, preparation method and application thereof
A technology of abiraterone acetate and its composition, which is applied in the direction of drug combination, drug delivery, and pharmaceutical formulation, which can solve the problems of slow drug dissolution rate and absorption, high risk of adverse reactions, and poor patient compliance, and achieve treatment costs. Effect of reducing, enriching drugs and pathways, increasing bioavailability
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Embodiment 1
[0081] Embodiment 1: Abiraterone acetate tablet preparation
[0082] (1) 69 parts of lactose and 10 parts of sodium starch glycolate are premixed to obtain a premix;
[0083] (2) Mix 10 parts of povidone and 100 parts of water to obtain an aqueous binder solution, and use a fluidized bed to prepare the premix and the aqueous binder solution into matrix particles;
[0084] (3) 10 parts of abiraterone acetate are dissolved in 300 parts of chloroform, sprayed onto the matrix particles, dried,
[0085] (4) granulate, add 1 part of magnesium stearate, mix, tabletting, obtain abiraterone acetate tablet.
Embodiment 2
[0086] Embodiment 2: Abiraterone acetate tablet preparation
[0087] (1) 50 parts of lactose and 9 parts of sodium starch glycolate are premixed to obtain a premix;
[0088] (2) Mix 20 parts of povidone and 200 parts of water to obtain an aqueous binder solution, and use a fluidized bed to prepare the premix and the aqueous binder solution into matrix particles;
[0089] (3) 20 parts of abiraterone acetate are dissolved in 600 parts of chloroform, sprayed onto the matrix particles, dried,
[0090] (4) granulate, add 1 part of magnesium stearate, mix, tabletting, obtain abiraterone acetate tablet.
Embodiment 3
[0091]Embodiment 3: preparation of abiraterone acetate tablet
[0092] (1) 50 parts of lactose, 10 parts of microcrystalline cellulose and 9.5 parts of sodium carboxymethyl starch are premixed to obtain a premix;
[0093] (2) Mix 20 parts of starch and 200 parts of water to obtain an aqueous binder solution, and use a fluidized bed to prepare the premix and the aqueous binder solution into matrix granules;
[0094] (3) 10 parts of abiraterone acetate are dissolved in 350 parts of chloroform and 350 parts of ethanol, sprayed onto the matrix particles, dried,
[0095] (4) granulate, add 0.05 part of magnesium stearate, mix, tabletting, obtain abiraterone acetate tablet.
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