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Hydrogel artificial cervical intervertebral disc based on stent reinforcement and preparation method thereof

A cervical intervertebral disc, hydrogel technology, applied in prosthesis, tissue regeneration, medical science and other directions, can solve problems such as poor mechanical properties and poor viscoelasticity, achieve good fatigue resistance, improve wear, and prevent excessive stress concentration. Effect

Active Publication Date: 2021-05-25
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] In view of the above-mentioned deficiencies and defects of the prior art, the object of the present invention is to provide a scaffold-based hydrogel artificial cervical intervertebral disc and its preparation method to solve the problem of poor viscoelasticity and poor mechanical properties of the artificial cervical intervertebral disc in the prior art. technical problem

Method used

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  • Hydrogel artificial cervical intervertebral disc based on stent reinforcement and preparation method thereof
  • Hydrogel artificial cervical intervertebral disc based on stent reinforcement and preparation method thereof
  • Hydrogel artificial cervical intervertebral disc based on stent reinforcement and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] Comply with the above technical solutions, such as Figure 1 to Figure 14 As shown, the present embodiment provides a method for preparing a scaffold-based hydrogel artificial cervical intervertebral disc,

[0092] Step 1: Prepare a prefabricated bracket;

[0093] Step 2: preparing the hydrogel prepolymerization solution;

[0094] Step 3: Fill the hydrogel prepolymer solution prepared in step 2 into the prefabricated scaffold prepared in step 1 to prepare a scaffold-based hydrogel artificial cervical intervertebral disc.

[0095] Step 2 The specific steps are as follows:

[0096] Step 1.1: Add 0.1g of acrylic acid and 0.5g of N,N-dimethylacrylamide to 2g of water and aluminum sol mixed liquid, and make N,N-methylbisacrylamide solution after magnetic stirring;

[0097] The parts by weight of aluminum-containing sol in the mixed solution of water and aluminum sol are 50%;

[0098] Step 1.2: Then add 0.1 wt% N,N-methylenebisacrylamide to the N,N-methylbisacrylamide sol...

Embodiment 2

[0151] Such as Figures 15-24 As shown, a preparation method of hydrogel artificial cervical intervertebral disc based on scaffold reinforcement,

[0152] Step 1: Prepare a prefabricated bracket;

[0153] Step 2: preparing the hydrogel prepolymerization solution;

[0154] Step 3: Fill the hydrogel prepolymer solution prepared in step 2 into the prefabricated scaffold prepared in step 1 to prepare a scaffold-based hydrogel artificial cervical intervertebral disc.

[0155] Step 2 The specific steps are as follows:

[0156] Step 2.1: Add 0.1g of acrylic acid and 0.5g of N,N-dimethylacrylamide into 2g of water and aluminum sol mixed solution, and make N,N-methylbisacrylamide solution after magnetic stirring;

[0157] The parts by weight of aluminum-containing sol in the mixed solution of water and aluminum sol are 50%;

[0158] Step 2.2: Then add 0.1wt% N,N-methylenebisacrylamide to the N,N-methylbisacrylamide solution, and then add 2 μL of potassium persulfate to prepare the ...

Embodiment 2

[0170] The performance test method of embodiment two is similar to that in embodiment 1:

[0171] 3.3 Mechanical test

[0172] 3.3.1 Strength test

[0173] 3.3.1.1 Axial compressive strength

[0174] Under the condition of 1.54kN (50% strain) in the axial direction, the shape of the three compressed samples remained intact, without damage and fiber exposure. The stress-strain curve of axial compression presents a "J"-shaped curve similar to that of the human intervertebral disc. Figure 20 And table 4) (the linear section modulus of human cervical intervertebral disc compressive stress-strain curve is 32MPa), the strain value of slope foot section is 0.21 ± 0.03 (the slope foot section of human body cervical intervertebral disc compressive stress-strain curve is 0.15 ± 0.02) .

[0175] Figure 20 A, Axial compression test; 20B, Axial compression stress-strain curve; 20C, Comparison between the prosthesis and the toe segment of human cervical intervertebral disc (Toe regio...

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Abstract

The invention provides a hydrogel artificial cervical intervertebral disc based on stent reinforcement. The hydrogel artificial cervical intervertebral disc based on stent reinforcement comprises a prefabricated stent and a hydrogel pre-polymerization solution, wherein the prefabricated stent is filled with the hydrogel pre-polymerization solution. According to the hydrogel artificial cervical intervertebral disc based on stent reinforcement, in the structure aspect, the prosthesis with the glass fiber as the support has a fiber arrangement mode similar to that of a human intervertebral disc fibrous ring in the micro-scale, and the prosthesis with TPU as the stent has a layered structure similar to that of the human intervertebral disc fibrous ring in the macro-scale. In the aspect of mechanical properties, a prosthesis constructed by the glass fiber reinforced composite gel is better in strength and fatigue resistance, and the viscoelasticity is closer to the cervical intervertebral disc of a human body. The product has biomechanical characteristics similar to human intervertebral disc, so that the problems of abrasion, adjacent segment degeneration and the like of the existing artificial cervical intervertebral disc prosthesis are effectively improved.

Description

technical field [0001] The invention belongs to the technical field of orthopedic surgery implants, and in particular relates to a scaffold-based hydrogel artificial cervical intervertebral disc and a preparation method thereof. Background technique [0002] The human intervertebral disc is a highly organized and multi-layered composite structure that plays an important role in the biomechanics of the spine. It can absorb shocks and disperse axial loads, and provide a certain range of motion for the spine. In the spine, the intervertebral disc, adjacent vertebral bodies and ligaments constitute a relatively independent mobile unit, which can also be regarded as a three-joint compound structure, which can be viewed in three orthogonal planes: the horizontal plane, the sagittal plane and the coronal plane. Generate translation or rotation. [0003] With the change of people's living habits and the increase of work pressure, cervical spondylosis has become a disease that plagu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/50A61L27/18A61L27/16A61L27/10C08F220/54C08F220/06C08F222/38C08J3/075C08L33/24
CPCA61L27/52A61L27/50A61L27/18A61L27/10A61L27/16C08F220/54C08J3/075C08J2333/24A61L2430/38C08F220/06C08F222/385C08L75/04C08L33/24
Inventor 雷伟卢昌波刘明杰严昊张扬黄鑫怡邱海洋杨晓江
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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