Etoricoxib in-situ gel and preparation method thereof
A technology of etoricoxib and in situ gel, which is applied in the field of medicine, can solve the problems of difficult drug administration, complicated process, and easy to cause adverse reactions, etc., and achieve the effect of good drug slow and controlled release performance, simple process, and accurate dosage
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[0035] The second aspect of the embodiment of the present application provides a preparation method of etoricoxisan in situ gel, comprising the following steps:
[0036] S10. Dissolving the polyethylene glycol block copolymer, poloxamer 188 and poloxamer 407 in the formula amount in a solvent, and swelling to obtain a clear and transparent blank in-situ gel;
[0037] S20. The etoricoxib in situ gel is obtained by mixing the prescribed amount of etoricoxib, the moisturizing agent and the blank in situ gel.
[0038] The preparation method of etoricoxisan in-situ gel provided by the second aspect of the present application comprises dissolving the polyethylene glycol block copolymer, poloxamer 188 and poloxamer 407 in a formula amount in a solvent such as water, and swelling A clear and transparent blank in situ gel was obtained, in which the temperature conditions were favorable for dissolving the polyethylene glycol block copolymer, poloxamer 188 and poloxamer 407 in water, and...
Embodiment 1
[0044] A kind of etoricoxi powder in situ gel, its preparation comprises steps:
[0045] 1. Take purified water, refrigerate overnight, measure purified water with 10% of the content of the gel matrix, put it in an ice-water bath, place it on a magnetic stirrer, and slowly add accurately weighed P407 while stirring (the content is shown in Table 1 shown), after uniform dispersion, store in the refrigerator at 4°C until fully swollen to obtain a clear and transparent blank in-situ gel.
[0046] 2. Take the prescribed amount of etoricoxib (14.1%), sieve it, and mix it with the blank plain gel to obtain the etoricoxib in situ gel.
[0047] The in situ gelation temperature of etoricoxib powder with different P407 content was measured, and the change of P407 content and the test results are shown in Table 1 below:
[0048] Table 1
[0049]
[0050] It can be seen from the test results in Table 1 that with the increase of the content of P407 in the prescription, the gelation te...
Embodiment 2
[0052] An etoricoxisan in situ gel, which differs from Example 1 in that 32% P407 and P188 in the following Table 2 are added in Step 1.
[0053] The in situ gelation temperature of etoricoxib powder with different P188 content was measured, and the change of P188 content and the test results are shown in Table 2 below:
[0054] Table 2
[0055]
[0056]
[0057] It can be seen from the test results in Table 2 that usually P407 is used in combination with P188 to overcome the shortcoming of too low gelling temperature. Fixed P407 prescription content, with the increase of P188 prescription content, the gelation temperature increases, and the gelation temperature can meet the requirements of the preparation, and the human body temperature can achieve phase transition. However, the mechanical strength of etoricoxib powder in situ gel is not obvious and needs to be improved, and the bioviscosity is too high.
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