Etoricoxib in-situ gel and preparation method thereof

A technology of etoricoxib and in situ gel, which is applied in the field of medicine, can solve the problems of difficult drug administration, complicated process, and easy to cause adverse reactions, etc., and achieve the effect of good drug slow and controlled release performance, simple process, and accurate dosage
CN112870156APending Publication Date: 2021-06-01深圳前海九华国际投资控股有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
深圳前海九华国际投资控股有限公司
Publication Date
2021-06-01

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to etoricoxib in-situ gel and a preparation method thereof. The etoricoxib in-situ gel is prepared from the following raw material components in parts by weight: 6 to 10 parts of etoricoxib, 20 to 30 parts of polyethylene glycol block copolymer, 1 to 2 parts of poloxamer 188, 15 to 20 parts of poloxamer 407 and 1 to 2 parts of humectant. The etoricoxib in-situ gel provided by the invention belongs to a temperature sensitive type, and can generate phase state reversible transformation between sol and gel when sensing temperature change. Therefore, the gel can exist in a solution form before administration, the administration is convenient, and the dosage is accurate; after administration, the gel can be converted into semi-solid gel along with the rise of temperature in vivo, is long in retention time at an administration part, has good drug sustained and controlled release performance, and is very suitable for being used as a local administration carrier. Meanwhile, the gel has the advantages of convenience in medicine storage, no toxicity, high biological tissue compatibility, good medicine stability and the like.
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Description

technical field

[0001] The application belongs to the technical field of medicine, and in particular relates to an etoricoxib powder in-situ gel and a preparation method thereof. Background technique

[0002] Etoricoxib (etoricoxib), a selective cyclooxygenase-2 inhibitor, has anti-inflammatory, analgesic and antipyretic effects, used for the treatment of acute and chronic osteoarthritis, and can also be used for the treatment of acute gouty arthritis. Etoricoxib, as a COX-2 (cyclooxygenase-2) inhibitor, compared with traditional non-steroidal anti-inflammatory drugs (NSAIDS), the former can make the occurrence of gastrointestinal peptic ulcer, perforation, bleeding The risk is reduced, and there is no sulfonamide group, which has higher safety for patients with sulfa allergy. Etoricoxib significantly reduced common adverse reactions of non-steroidal anti-inflammatory drugs (NSAIDs), including gastrointestinal mucosal damage, liver and kidney toxicity, allergic reactions, ...

Claims

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