Novel composite material for sterilization, disinfection and rapid hemostasis as well as preparation and application

A composite material, sterilization and disinfection technology, applied in the field of biomedicine, can solve the problems of easy loss of active ingredients, easy contamination of wounds, and unsatisfactory hemostasis effect on irregular-shaped wounds, so as to prevent wound infection, quickly and effectively stop bleeding, and inhibit bacterial growth. Effect

Active Publication Date: 2021-06-04
HUBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some traditional hemostatic materials (such as cotton gauze, bandages) can stop bleeding by directly pressing the wound, but the hemostatic effect on irregular shaped wounds is not ideal
Among inorganic hemostatic materials, clay and combat gauze (kaolin impregnated gauze) can be used as emergency hemostatic materials, but they have problems such as easy loss of active ingredients and easy contamination of wounds

Method used

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  • Novel composite material for sterilization, disinfection and rapid hemostasis as well as preparation and application
  • Novel composite material for sterilization, disinfection and rapid hemostasis as well as preparation and application
  • Novel composite material for sterilization, disinfection and rapid hemostasis as well as preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Preparation of mCHA-NW

[0075] Take 0.25g NaOH and 0.068g Al(OH) 3 Add it into 16.0mL ultrapure water, put it in a stainless steel autoclave at 100°C for 18 hours to dissolve it completely, and prepare A solution. Take 0.2g NaOH and 1.25g silica gel (30wt%) and add it into 6.8mL ultrapure water, stir at room temperature for 12h to dissolve completely, and prepare solution B. The prepared A solution was added dropwise to the B solution. During the dropwise addition, the B solution was vigorously stirred at room temperature. After the dropwise addition, the mixed solution continued to be vigorously stirred at room temperature for 3-4 hours. Take 0.2-0.3g of non-woven fabric and cut it into small squares of 2-3cm, put it into the above mixed solution, soak it at room temperature for 3-4h, put it in a 100℃ reactor for hydrothermal crystallization for 24h, and finally soak it in 0.5M CaCl 2 In the solution for 12h, soak twice at room temperature.

Embodiment 2

[0077] Preparation of mCHA-NW

[0078] Take 0.5g NaOH and 0.136g Al(OH) 3 Add it into 16.0mL ultrapure water, put it in a stainless steel autoclave at 100°C for 18 hours to dissolve it completely, and prepare A solution. Take 0.4g NaOH and 2.5g silica gel (30wt%) and add it into 6.8mL ultrapure water, stir at room temperature for 12h to dissolve completely, and prepare solution B. The prepared A solution was added dropwise to the B solution. During the dropwise addition, the B solution was vigorously stirred at room temperature. After the dropwise addition, the mixed solution continued to be vigorously stirred at room temperature for 3-4 hours. Take 0.2-0.3g of non-woven fabric and cut it into small squares of 2-3cm, put it into the above mixed solution, soak it at room temperature for 3-4h, put it in a 100℃ reactor for hydrothermal crystallization for 24h, and finally soak it in 0.5M CaCl 2 In the solution for 12h, soak twice at room temperature.

Embodiment 3

[0080] Preparation of mCHA-NW

[0081] Take 1.0g NaOH and 0.273g Al(OH) 3 Add it into 16.0mL ultrapure water, put it in a stainless steel autoclave at 100°C for 18 hours to dissolve it completely, and prepare A solution. Take 0.8g NaOH and 5.0g silica gel (30wt%) and add it into 6.8mL ultrapure water, stir at room temperature for 12h to dissolve completely, and prepare solution B. The prepared A solution was added dropwise to the B solution. During the dropwise addition, the B solution was vigorously stirred at room temperature. After the dropwise addition, the mixed solution continued to be vigorously stirred at room temperature for 3-4 hours. Take 0.2-0.3g of non-woven fabric and cut it into small squares of 2-3cm, put it into the above mixed solution, soak it at room temperature for 3-4h, put it in a 100℃ reactor for hydrothermal crystallization for 24h, and finally soak it in 0.5M CaCl 2 In the solution for 12h, soak twice at room temperature.

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Abstract

The invention discloses a novel composite material for sterilization, disinfection and rapid hemostasis as well as preparation and application. Firstly, mesoporous chabazite non-woven fabric is prepared, then the mesoporous chabazite non-woven fabric is taken as a matrix, silver nitrate and beta-cyclodextrin are added, and pH is adjusted to be alkaline, so that the outer surface of the mesoporous chabazite non-woven fabric is coated with a layer of silver nanoparticle material. Mesoporous chabazite is attached to the surface of non-woven fabric fiber by a template-free in-situ growth method, so that the non-woven fabric fiber is tightly joined with the zeolite. The beta-cyclodextrin has reducing capacity and stabilizing capacity in the AgNPs (nanoparticles) synthesis process, so that Ag ions can be reduced into Ag atoms by adjusting pH to be alkaline, and AgNPs are formed in situ. The mesoporous chabazite non-woven fabric has excellent hemostatic performance and can be used for massive hemorrhage of wounds. The AgNPs have good antibacterial performance and can effectively avoid re-infection of wounds, the purposes of stopping bleeding and resisting bacteria can be achieved through combination of the mesoporous chabazite non-woven fabric and the AgNPs, and the death rate of massive hemorrhage is greatly reduced.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a novel composite material used for sterilization and rapid hemostasis, as well as its preparation and application. Background technique [0002] Excessive traumatic bleeding can lead to death, and rapid hemostasis is the key to ensure the survival of patients. Some traditional hemostatic materials (such as cotton gauze and bandages) can stop bleeding by directly pressing the wound, but the hemostatic effect on irregular shaped wounds is not ideal. Among inorganic hemostatic materials, clay and combat gauze (kaolin impregnated gauze) can be used as emergency hemostatic materials, but they have problems such as easy loss of active ingredients and easy contamination of wounds. In recent years, composite hemostatic materials have developed rapidly. Zeolite provides a new idea for the development of new hemostatic materials due to its good adsorption and excellent hemostatic e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/18A61L15/44A61L15/46A61L15/28A61L15/42
CPCA61L15/18A61L15/44A61L15/46A61L15/28A61L15/42A61L2400/04A61L2300/104A61L2300/624A61L2300/404A61L2300/418
Inventor 孙红梅李申万
Owner HUBEI UNIV OF TECH
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