Superhydrophobic multifunctional coating with sequential drug release and preparation method thereof

A multi-functional coating and super-hydrophobic technology, applied in coatings, drug delivery, pharmaceutical formulations, etc., can solve problems such as the difficulty in further constructing super-hydrophobic synergistic slow-release drug coatings, unstable super-hydrophobic surface structures, etc., and achieve excellent Biological function, promotion of endothelial cell growth, effect of simple operation
CN112957543BActive Publication Date: 2022-05-20WEST CHINA HOSPITAL SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
WEST CHINA HOSPITAL SICHUAN UNIV
Publication Date
2022-05-20

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Abstract

The invention discloses a super-hydrophobic multifunctional coating with sequential drug release and a preparation method thereof. The preparation method comprises the following steps: S1. polishing, cleaning and drying the base material, and then placing it in an acid buffer solution, and then Add dopamine, endothelial cell growth-promoting drugs and oxidants, react in an environment of 10-40°C for 1-50h, and wash to obtain a substrate material containing composite nanoparticles on the surface; S2. Dilute with 1H, 1H, 2H, 2H-perfluorododecanethiol to obtain a drug / fluoride mixed dilution; S3. Soak the substrate material containing composite nanoparticles on the surface obtained in S1 in the drug / fluoride mixture obtained in S2 The diluted solution is irradiated with ultraviolet light for 0.1-5h, washed, and dried with nitrogen gas. The preparation method of the present invention is simple, the reaction conditions are mild, the repeatability is good, the cost is low, and it is easy to popularize and use, and the prepared coating material can release medicines in time sequence according to the service environment requirements.
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Description

technical field

[0001] The invention belongs to the technical field of biomedical functional materials, in particular to a superhydrophobic multifunctional coating with sequential drug release and a preparation method thereof. Background technique

[0002] Once blood-contact materials come into contact with blood, the proteins in the blood, especially fibrinogen, will adhere and denature on the surface of the material in a short period of time to form fibrin, which makes platelets adhere, activate and aggregate, followed by more Fibrinogen denaturation and platelet adhesion, activation and aggregation, and red blood cell network, and finally the acute formation of thrombus. At the same time, the non-specific adhesion of the protein on the surface of the material allows the body to be recognized by the macrophages of the immune system. When the macrophages cannot swallow foreign matter, they form giant cells through self-fusion and secrete cytokines (peak within 24 hours). ,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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