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Application of a composition in prevention and treatment of alcoholic brain injury

A composition and alcohol-based technology are used in the prevention and treatment of alcohol-induced brain injury. Low problems, to achieve the effect of improved physical properties and taste, no bad smell, easy industrial production

Active Publication Date: 2021-10-22
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of these substances have a wide range of curative effects, can increase the activity of antioxidant enzymes in the body, and reduce oxidative damage to the brain, but it is difficult to explain the protective mechanism of alcoholic brain damage, and the bioavailability of antioxidant active substances is low

Method used

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  • Application of a composition in prevention and treatment of alcoholic brain injury
  • Application of a composition in prevention and treatment of alcoholic brain injury
  • Application of a composition in prevention and treatment of alcoholic brain injury

Examples

Experimental program
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Effect test

Embodiment 1

[0053] A composition for preventing and treating alcoholic brain damage comprises the following components in parts by weight: 20 parts of seaweed polyphenol, 4 parts of sodium alginate, 40 parts of abalone peptide and 1.5 parts of spermidine.

[0054] The preparation method of described composition comprises the following steps:

[0055] S1. According to the stated parts by weight, add sodium alginate into distilled water to prepare a 1.5wt% sodium alginate solution, adjust the pH of the solution to 6.5, add spermidine, stir at room temperature for 6.5 hours, treat in an ice-water bath, and wait for the solution system to cool down to 8°C, add seaweed polyphenols, continue to stir for 2 hours, freeze-dry, and crush with liquid nitrogen to obtain seaweed polyphenol composite powder;

[0056] S2. Dissolve the abalone peptide in distilled water to prepare a 22wt% abalone peptide solution, add the seaweed polyphenol composite powder described in S1 under stirring, suspend evenly,...

Embodiment 2

[0058] A composition for preventing and treating alcoholic brain damage comprises the following components in parts by weight: 15 parts of seaweed polyphenol, 3 parts of sodium alginate, 35 parts of abalone peptide and 1 part of spermidine.

[0059] The preparation method of described composition comprises the following steps:

[0060] S1. According to the stated parts by weight, add sodium alginate into distilled water to prepare a 2.0wt% sodium alginate solution, adjust the pH of the solution to 7.0, add spermidine, stir at room temperature for 7 hours, treat in an ice-water bath, and wait for the solution system to cool down to 6°C, add seaweed polyphenols, continue to stir for 1.5 hours, freeze-dry, and crush with liquid nitrogen to obtain seaweed polyphenol composite powder;

[0061] S2. Dissolve the abalone peptide in distilled water to prepare a 24wt% abalone peptide solution according to the parts by weight, add the seaweed polyphenol composite powder described in S1 u...

Embodiment 3

[0063] A composition for preventing and treating alcoholic brain damage comprises the following components in parts by weight: 10 parts of seaweed polyphenol, 2 parts of sodium alginate, 30 parts of abalone peptide and 0.5 part of spermidine.

[0064] The preparation method of described composition comprises the following steps:

[0065] S1. According to the parts by weight, take sodium alginate and add distilled water to prepare a 1wt% sodium alginate solution, adjust the pH of the solution to 6.0, add spermidine, stir at room temperature for 5 hours, treat in an ice-water bath, and wait for the solution system to cool down to At 5°C, add seaweed polyphenols, continue to stir for 1 hour, freeze-dry, and crush with liquid nitrogen to obtain seaweed polyphenol composite powder;

[0066] S2. Dissolve the abalone peptide in distilled water according to the parts by weight to prepare a 18wt% abalone peptide solution, add the seaweed polyphenol composite powder described in S1 unde...

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Abstract

The invention discloses the application of a composition in the prevention and treatment of alcoholic brain injury, which belongs to the technical field of biomedicine. The invention provides the application of a composition in the preparation of pharmaceutical preparations for the prevention and treatment of alcoholic brain injury. In terms of parts, it includes the following components: 10-30 parts of seaweed polyphenols, 2-6 parts of sodium alginate, 30-55 parts of abalone peptide and 0.5-3 parts of spermidine; The combination of polyphenols and abalone peptides rich in various nutrients and multiple biological effects has been proved by animal experiments that the composition exerts multi-channel, multi-target and synergistic effects in the prevention and treatment of alcoholic brain damage. At the same time, the present invention has Good product stability, high bioavailability, safe and non-toxic, easy to take, no bad smell, good compliance.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of a composition in the prevention and treatment of alcoholic brain injury. Background technique [0002] With the progress of the society and the rapid development of the economy, the living standards of our people have been significantly improved, and the demand for alcohol consumption is increasing. Chronic alcoholism has become one of the global public health problems. The influence of alcohol on body organs and its various systems mainly spreads beyond the liver through liver metabolism, including the central nervous system, cardiovascular system, immune system, kidneys, lungs, gastrointestinal tract, pancreas and other organs. [0003] The cerebral cortex of people who drink alcohol for a long time will be in a state of anesthesia, and the damage to the nervous system will manifest as a series of thinking and behavior release states, such as mental disor...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/01A61K36/02A61K47/36A61K47/54A61P25/00A61P39/06
CPCA61K38/012A61K36/02A61K47/36A61K47/54A61P25/00A61P39/06A61K2300/00A61K9/2059A61K9/4866A61K9/4858A61K9/1652A61K35/618A61K38/00A61P25/32A61K31/734A61K31/132
Inventor 胡章卢思彤洪鹏志孔松芝赵云涛钟赛意李程鹏程瑜
Owner GUANGDONG OCEAN UNIVERSITY