Exocarpium citri grandis composition with effects of relieving cough and reducing sputum and preparation method of exocarpium citri grandis composition
A technology for relieving cough, reducing phlegm, and removing orange red, which can be applied to medical preparations containing active ingredients, active ingredients of hydroxyl compounds, drug combinations, etc., and can solve the problems of poor scientificity of component compounding, bitter taste of orange red, and inconvenient use. , to achieve the effect of improving consumer compliance
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Embodiment 1
[0032] A huajuhong composition with the effect of relieving cough and reducing phlegm, made of the following components in parts by weight:
[0033] 15 parts of Huajuhong extract, 15 parts of Cordyceps militaris extract, 20 parts of chrysanthemum powder, 34 parts of isomalt (auxiliary material), 1 part of neohesperidin dihydrochalcone (auxiliary material), 0.2 part of natural menthol , 0.2 parts of sucralose (excipient).
[0034] The preparation method of the composition for relieving cough, reducing phlegm and resolving orange red is as follows:
[0035] (1) 0.2 parts of natural menthol and 2 parts of isomalt were heated and stirred for 5-10 minutes, mixed evenly, and sieved to obtain pretreated raw materials;
[0036] (2) Add the pretreated raw material obtained in step (1) and 1 part of neohesperidin dihydrochalcone to the remaining 32 parts of isomalt according to the method of equal increase, add in 3 times, mix 5 times each time Minutes, mix well, obtain the premix;
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Embodiment 2
[0040] A kind of Huajuhong jelly candy with the effect of relieving cough and reducing phlegm of this embodiment is made of the following components in parts by weight:
[0041] 15 parts of Huajuhong extract, 15 parts of Cordyceps militaris extract, 15 parts of kumquat powder, 20 parts of lemon juice powder, 49 parts of isomalt (excipient additive), 20 parts of glucose (excipient additive), guar gum (Auxiliary material additive) 1 part, citric acid (Adjunct material additive) 0.2 part, mogroside (Adjunct material additive) 0.1 part, sucralose (Auxiliary material additive) 0.1 part, natural menthol 0.2 part, coating agent (soybean lecithin, wood Sugar alcohol, caramel color, water) (auxiliary material additive) 40 parts.
[0042] The preparation method of the cough-relieving and phlegm-resolving orange-red jelly candy is as follows:
[0043] (1) The raw and auxiliary materials are passed through a 40-mesh sieve, except for natural menthol;
[0044] (2) Mix 0.2 parts of natura...
Embodiment 3
[0050] The HJH composition prepared in Example 1 (hereinafter referred to as HJH) was used as the research object to carry out the cough experiment in mice induced by ammonia water.
[0051] 1. Experimental animals:
[0052] There were 48 SPF KM mice, half male and half male; the body weight was 22-27 g at the time of the test, and they were 6 weeks old.
[0053] 2. Experimental method:
[0054] a. Take KM mice and place them one by one in polyethylene containers (mouse cages) one day before the experiment. Spray fresh concentrated ammonia water with an ultrasonic nebulizer, atomize parameters 2-5, atomize for 2.5 minutes, observe and record the number of mice coughing within 5 minutes. After the parameters are set in the pre-test, the formal test animals are screened. The specific screening criteria are set according to the actual number of coughs detected. Animals that do not cough or die are eliminated, and about 90% of the qualified animals are selected.
[0055] b. Ran...
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