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Preparation method of biological sterilization preparation and application thereof

A biological and preparation technology, applied in botany equipment and methods, fungicides, chemicals for biological control, etc., can solve skin and mucous membrane irritation, bacterial drug resistance is not suitable for long-term use and preventive use, and antibacterial spectrum Insufficient wide and other problems, to achieve the effect of high safety, good sterilization effect and strong stability

Pending Publication Date: 2021-06-22
昆山博青生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the sensitivity of these parts, the requirements for therapeutic drugs are higher. The common existing disinfectants can irritate the skin and mucous membranes, the antibacterial spectrum is not wide enough, or the antibacterial mechanism itself may easily lead to bacterial resistance. It is not suitable for long-term use and prevention. use, existing disinfectants have many shortcomings and cannot meet the above requirements

Method used

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  • Preparation method of biological sterilization preparation and application thereof
  • Preparation method of biological sterilization preparation and application thereof
  • Preparation method of biological sterilization preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Composition and proportioning ratio: (percentage by weight)

[0034] Biological antibacterial peptide K11 0.001%; ​​Polyhexamethylene biguanide (PHMB) 1%; Glycine 1%; Chitosan 1%; Glycerin 1%; Potassium dihydrogen phosphate 1%; Disodium hydrogen phosphate 1%; Sodium chloride 0.1%; the rest with distilled water.

[0035] 2. Preparation steps

[0036] (1) Potassium dihydrogen phosphate and disodium hydrogen phosphate are dissolved in distilled water to obtain solution A;

[0037] (2) According to the prescription of the preparation, weigh the required biological antimicrobial peptide K11, polyhexamethylene biguanide and glycine, add to the solution of part A, stir and dissolve, and obtain solution B.

[0038] (3) Chitosan and sodium chloride are taken by weighing and dissolved in distilled water to obtain solution C;

[0039] (4) After mixing the above solution B and solution C, add glycerin and stir evenly to obtain the finished product.

[0040] Packed in plastic...

Embodiment 2

[0042] 1. Composition and proportioning ratio: (percentage by weight)

[0043] Biological antibacterial peptide K11 10%; polyhexamethylene biguanide (PHMB) 0.01%; glycine 8%; chitosan 10%; glycerin 5%; potassium dihydrogen phosphate 20%; disodium hydrogen phosphate 30%; sodium chloride 2%; the rest is distilled water, and the weight percentage sum of each component is 100%.

[0044] 2. The preparation method is the same as in Example 1;

[0045] Packed in plastic or glass bottles and used directly as a disinfectant; it can also be packed in a spray bottle with a manual pump to prepare a disinfectant spray; it can also be used as a wet wipe to add liquid to absorb in non-woven fabrics to make a hygienic wipes.

Embodiment 3

[0047] 1. Composition and ratio

[0048] Biological antimicrobial peptide K11 1%; polyhexamethylene biguanide (PHMB) 0.02%; glycine 2%; chitosan 2%; glycerin 3%; potassium dihydrogen phosphate 10%; disodium hydrogen phosphate 20%; sodium chloride 1%; the rest is distilled water, and the weight percentage sum of each component is 100%.

[0049] 2. The preparation method is the same as in Example 1.

[0050] Packed in plastic or glass bottles and used directly as a disinfectant; it can also be packed in a spray bottle with a manual pump to prepare a disinfectant spray; it can also be used as a wet wipe to add liquid to absorb in non-woven fabrics to make a hygienic wipes.

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Abstract

The invention discloses a biological sterilization preparation, a preparation method and an application thereof, the biological sterilization preparation takes water as a carrier, and comprises the following components by weight percent: 0.001-10% of biological antibacterial peptide K11; and 0.01 to 1% of polyhexamethylene biguanide (PHMB). The product has a good sterilizing effect. A core sterilization component of the preparation is novel antibacterial peptide which has a very strong sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. The sterilization rate can reach 99.9% after 2-5 minutes of in-vitro experiment. The product is high in safety, free of toxicity or residues to human bodies, high in stability and capable of being used as a preventive drug. The main acting component is a biological agent, and the defects that a traditional chemical preparation has irritation to mucosa, and bacteria easily generate drug resistance are overcome. The composition is easily accepted by organisms and has no toxic or side effect. The product is suitable for long-term use or preventive medication.

Description

technical field [0001] The invention relates to a biological bactericidal preparation, a preparation method and an application thereof. Background technique [0002] At present, clinical bacterial infection is quite serious, and it has become a major killer threatening human health in the past 20 years. Moreover, an increasing number of bacteria are resistant to antibiotic treatment, posing a serious threat to public health. In the United States, more lives were lost to drug-resistant bacterial infections in 1998 than in Vietnam. Germs that were once easily killed by antibiotics, such as Staphylococcus aureus, Pneumococcus pneumococcus, Pseudomonas aeruginosa, Candida albicans, Escherichia coli, etc., are now becoming more and more fierce due to the emergence of drug resistance, making people more and more serious. More and more helpless. Among them, drug-resistant Staphylococcus aureus is the most active molecule. The infection caused by it not only has poor curative eff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K31/785A61K47/18A61K47/36A61P31/04A61P31/10A01N43/50A01N47/44A01P1/00A01P3/00
CPCA01N43/50A01N47/44A61K31/785A61K38/10A61K47/183A61K47/36A61P31/04A61P31/10A61K2300/00Y02A50/30
Inventor 叶贵子黄青山
Owner 昆山博青生物科技有限公司
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