32results about How to "Overcome the disadvantage of prone to drug resistance" patented technology

The invention provides a formula of medicine for preventing and curing coccidiosis of chicken, which comprises Chinese medicinal antibiotic medicament and Nicarbazinum, the Chinese medicament is in the form of compound powder preparation which comprises dichroa febrifuga 500-1000ppm, coptis root 500-100 ppm, green chiretta 500-1000ppm.

The invention belongs to the technical field of medicines, and specifically relates to a suppository for treating mammal endometritis. The preparation disclosed in the invention comprises the following components of: by weight, 0.004-0.01% of staphylococcus lysozyme, 0.1-4% of lysozyme, 10-80% of semisynthetic fatty glyceride, 1-20% of poloxamer 188(F68), 1-20% of HPMC, 5-50% of sodium bicarbonate and 5-50% of sodium dihydrogen phosphate. After the preparation provided by the invention enters into mammal uterus through administration, the preparation can undergo effervescence decomposition in a body fluid. The medicine is mixed in foams and rapidly released. Contact area between the medicine and mucosal of uterus becomes larger and the medicine can penetrate into deep portions of mucosa wrinkles so as to prolong the action time between the medicine and the mucosa, raise the concentration of the medicine on local tissues, further enhance the curative effect and effectively kill various pathogens which can cause endometritis.

The invention discloses a biological antibacterial polypeptide preparation as well as a preparation method and application of the biological antibacterial polypeptide preparation. The biological antibacterial polypeptide preparation takes water as a carrier and is prepared from the following components in percentage by weight: 0.1 percent to 10 percent of a biological antibacterial peptide BQ and 0.01 percent to 1 percent of polyhexamethylene biguanidine. The biological antibacterial polypeptide preparation has good sterilization effect. A core sterilization component of the preparation is a novel antibacterial peptide and has very high sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. When an in-vitro experiment is carried out for 2min to 5min, 99.9 percent of sterilization rate can be realized. The biological antibacterial polypeptide preparation has high safety, has no toxicity to or residues to human bodies, has high stability and can be used as a prevention medicine. The main acting component is a biological preparation and the disadvantages that a traditional chemical preparation has irritation on mucosa and bacteria easily have drug resistance are overcome. The biological antibacterial polypeptide preparation is easily accepted by organisms, has no toxic side effect and is suitable for long-time utilization or used as the prevention medicine.

The invention discloses a herbicide composition containing sulfometuron methyl and MCPA-Na. The herbicide composition comprises the sulfometuron methyl and the MCPA-Na as active components and other additives comprising acetone, sodium hydroxide, sodium lignosulfonate, sodium chloride, xanthan gum and organic silicon. The herbicide composition solves a problem of drug resistance on the sulfometuron methyl in various weeds, is improved in fast-acting property and is long in effective time.

The invention relates to a Chinese medicinal granular formulation for increasing egg production of poultry which is prepared from 9 Chinese medicinal materials including astragalus, japanese teasel, atractylodes, eucommia bark, white peony root, psoralea fruit, Chinese yam, jujube, villous amomum. The medicament has effects of clearing away heat and toxic material, resolving dampness and fortifying the spleen, supplying qi and strengthening yang that is mainly used for treating egg production reduced and recovering egg production capability, can increase egg production and delay egg production fastigium. At the same time, the medicament formulation is the granular formulation by considering special physiological structure of poultry that genital tract is short and can not digest wood fibre, and can be dispersed rapidly, the sick poultry takes medicament by drinking water which is convenient and is easy to absorb, and can get rapid effect.

The invention discloses a pesticide composition for controlling banana thrips. The composition includes active ingredients and auxiliary agents, and the active ingredients include d-limonene and diethyl aminoethyl hexanoate. The active ingredient accounts for 2.5% to 12% of the total weight of the pesticide composition. The invention finds that diethyl aminoethyl hexanoate has a preventive and control effect on banana thrips, and the compounding of d-limonene and diethyl aminoethyl hexanoate has obvious synergistic effect, and the control effect on banana thrips is better than the single component of diethyl hexanoate and d-limonene Control effect on banana thrips.

The invention belongs to the technical field of medicines, and particularly relates to an effervescent suppository for treating mammal vaginitis. A preparation disclosed by the invention consists of the following components in percentage by weight: 0.01-0.04 percent of recombinant lysostaphin, 10-50 percent of lactose, 5-30 percent of microcrystalline cellulose, 1-20 percent of polyoxyl[40]stearate, 1-10 percent of povidone, 5-40 percent of sodium bicarbonate, 5-40 percent of sodium dihydrogen phosphate and 0.1-5 percent of superfine silica powder. The preparation can disintegrate in an effervescent manner in the presence of body fluid after entering the vagina of a mammal, and medicaments are released rapidly by being mixed in foam, so that the contact area between the medicaments and vaginal mucosa is increased, the medicaments can permeate deep into mucosa folds, the acting time of the medicaments on mucosa is prolonged, the local tissue medicament concentration is increased, the treatment effect is enhanced, and various pathogenic bacteria causing vaginitis are killed effectively.

The invention discloses an agricultural bactericidal composition containing bupirimate and azoxystrobin. The agricultural bactericidal composition is prepared from effective components including the bupirimate and the azoxystrobin. The agricultural bactericidal composition solves the problem of insecticide resistance caused by long-term use of single doses of two products, namely the bupirimate and the azoxystrobin separately, and a mixture of the bupirimate and the azoxystrobin has the obvious synergism on controlling powdery mildew.