32results about How to "Overcome the disadvantage of prone to drug resistance" patented technology

The invention relates to a traditional Chinese medicine (TCM) oral liquid used for treating animal respiratory tract infection, which includes folium eriobotryae, aster, radix stemonae, fritillaria thunbergii, perilla leaves, bitter almond, ephedra herb, rhizoma pinellinae praeparata, tuckahoe, dried orange peel, asparagus, mustard seeds, radix glehniae, tussilago farfara, bitter orange, semen trichosanthis, radrx peucedani, liquorice and balloon flowers. The medicament is suitable for treating avian respiratory tract infection, such as infectious bronchitis, infectious laryngotracheitis and the like. The formulation of the medicament is combined with the special physiological structures that birds have short genital tract and can not digest lignified fibers to prepare the medicament into oral liquid which can rapidly disperse in feeding water, and then sicken beasts and birds take medicaments by drinking. The TCM oral liquid is convenient, easy to absorb and can achieve the purpose of rapid effect.

The invention relates to a premixing agent for treating livestock nematodiasis, comprising ivermectin, albendazol and auxiliary materials. The premixing agent is mainly used for preventing and treating livestock digestive canal nematodiasis and so on parasitic insect disease, has good preventing and treating actions for livestock digestive canal nematodiasis and ectozoa. The invention can treat the nematodiasis, meanwhile can prevent and treat the infection of the livestock parasite in vitro, can effectively improve the parasite-expelling effect, and has high safety.

The invention relates to a traditional Chinese medical oral liquid used for curing colibacillosis of poultries, which comprises four medicines of purslane, heartleaf houtluynia, Chinese pulsatilla and phellodendron. The combination of the four medicines has the effects of clearing away heat and toxic material, curing dysentery and improving the symptom of diarrhea caused by colon bacillus. Based on the fact that the specific physiological structure of poultries can not digest wood fibre owing to the short genital tracts, the medicaments are made into a dosage form of oral liquid which can be dispersed in drinking water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

A freeze-dried powder-injection of staphylococcus lysozyme for preventing and treating the endometritis of cow and the skin mucosa infection of other animals, and cleaning and restoring the postpartum uterus of cow is composed of staphylococcus lysozyme, bovine serum albumin, glycine, mannitol, and phosphate. Its preparing process is also disclosed.

The invention provides a formula of medicine for preventing and curing coccidiosis of chicken, which comprises Chinese medicinal antibiotic medicament and Nicarbazinum, the Chinese medicament is in the form of compound powder preparation which comprises dichroa febrifuga 500-1000ppm, coptis root 500-100 ppm, green chiretta 500-1000ppm.

The invention relates to a traditional Chinese medical oral liquid used for curing respiratory tract infection of poultries and cattle, which comprises eleven medicaments of radix isatidis, forsythia, baikal skullcap root, Chinese ephedra, aster, almond, plaster, artificial bezoar, borneol, senso and liquorice. The medical oral liquid is suitable for curing respiratory tract infection of poultries and cattle, such as infective bronchitis, infectious laryngotracheitis, etc. Based on the fact that the specific physiological structure of poultries can not digest wood fibre owing to the short genital tracts, the medicaments are made into a dosage form of oral liquid which can be dispersed in drinking water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The invention discloses a biological sterilization preparation, a preparation method and an application thereof, the biological sterilization preparation takes water as a carrier, and comprises the following components by weight percent: 0.001-10% of biological antibacterial peptide K11; and 0.01 to 1% of polyhexamethylene biguanide (PHMB). The product has a good sterilizing effect. A core sterilization component of the preparation is novel antibacterial peptide which has a very strong sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. The sterilization rate can reach 99.9% after 2-5 minutes of in-vitro experiment. The product is high in safety, free of toxicity or residues to human bodies, high in stability and capable of being used as a preventive drug. The main acting component is a biological agent, and the defects that a traditional chemical preparation has irritation to mucosa, and bacteria easily generate drug resistance are overcome. The composition is easily accepted by organisms and has no toxic or side effect. The product is suitable for long-term use or preventive medication.

The invention discloses a compound weeding composition containing glufosinate-ammonium. The compound weeding composition comprises, by weight, 5 to 80% of active components consisting of glufosinate-ammonium and clomeprop in a weight ratio of 1: 20 to 20: 1, with the balance being auxiliary agents. The dosage form of the compound weeding composition may be a wettable powder, a water dispersible granule, a suspension concentrate, an oil concentrate, etc. The compound weeding composition can compensate for the defect that single glufosinate-ammonium has poor effect on cyperaceous drug-resistant weeds like Cyperus rotundus and the defect that single clomeprop can only control broadleaf weeds and cyperaceous weeds and almost has no effect on gramineous weeds, and is capable of effectively preventing and eliminating weeds; and the two above active components in a certain ratio range present synergistic effect and exert better effect compared with single glufosinate-ammonium and single clomeprop, so the dosage of pesticides is reduced, adverse impact of pesticides on ecological environment is lowered, and good prevention effect is exerted on gramineous weeds like Cyperus rotundus which is hard to prevent and eliminate with glufosinate-ammonium.

The invention relates to a traditional Chinese medical oral liquid used for curing diarrhea of poultries, which comprises two medicines of heartleaf houtluynia and honeysuckle. The medicament is suitable for curing the infection of digestive canal such as diarrhea and the like of poultries caused by germ. Based on the fact that the specific physiological structure of poultries can not digest wood fibre owing to the short genital tracts, the medicament is made into a dosage form of oral liquid which can be dispersed in drinking water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The invention belongs to the technical field of medicines, and specifically relates to a suppository for treating mammal endometritis. The preparation disclosed in the invention comprises the following components of: by weight, 0.004-0.01% of staphylococcus lysozyme, 0.1-4% of lysozyme, 10-80% of semisynthetic fatty glyceride, 1-20% of poloxamer 188(F68), 1-20% of HPMC, 5-50% of sodium bicarbonate and 5-50% of sodium dihydrogen phosphate. After the preparation provided by the invention enters into mammal uterus through administration, the preparation can undergo effervescence decomposition in a body fluid. The medicine is mixed in foams and rapidly released. Contact area between the medicine and mucosal of uterus becomes larger and the medicine can penetrate into deep portions of mucosa wrinkles so as to prolong the action time between the medicine and the mucosa, raise the concentration of the medicine on local tissues, further enhance the curative effect and effectively kill various pathogens which can cause endometritis.

The invention belongs to the technical field of medicines, and particularly relates to an effervescent suppository for treating mammal vaginitis. A preparation disclosed by the invention consists of the following components in percentage by weight: 0.01-0.04 percent of recombinant lysostaphin, 10-50 percent of lactose, 5-30 percent of microcrystalline cellulose, 1-20 percent of polyoxyl[40]stearate, 1-10 percent of povidone, 5-40 percent of sodium bicarbonate, 5-40 percent of sodium dihydrogen phosphate and 0.1-5 percent of superfine silica powder. The preparation can disintegrate in an effervescent manner in the presence of body fluid after entering the vagina of a mammal, and medicaments are released rapidly by being mixed in foam, so that the contact area between the medicaments and vaginal mucosa is increased, the medicaments can permeate deep into mucosa folds, the acting time of the medicaments on mucosa is prolonged, the local tissue medicament concentration is increased, the treatment effect is enhanced, and various pathogenic bacteria causing vaginitis are killed effectively.

The invention provides a formula of medicine for preventing and curing coccidiosis of chicken, which comprises Chinese medicinal antibiotic medicament and Nicarbazinum, the Chinese medicament is in the form of compound powder preparation which comprises dichroa febrifuga 500-1000ppm, coptis root 500-100 ppm, green chiretta 500-1000ppm.

The invention discloses a pesticide composition for preventing and treating banana thrips. The composition comprises active ingredients and an auxiliary agent, and the active ingredients comprise d-limonene and diethyl aminoethyl hexanoate. The active ingredients account for 2.5%-12% of the total weight of the pesticide composition. The diethyl aminoethyl hexanoate has a prevention and treatment effect on the banana thrips, the d-limonene and the diethyl aminoethyl hexanoate are compounded to achieve an obvious synergistic effect, and the prevention and treatment effect on the banana thrips is superior to the prevention and treatment effect of a single component of the diethylaminoethyl hexanoate and the d-limonene on the banana thrips.

The invention relates to application of a coryebactrium parvum preparation (CPP) or a noncellular coryebactrium parvum preparation (NCP) in the field of pharmacy, in particular to application in preparing a medicament for treating novel A H1N1 influenza viruses. The coryebactrium parvum preparation is a preparation prepared by inactivating coryebactrium parvum through formaldehyde; and the noncellular coryebactrium parvum preparation is of a nanometer grade and has uniform grain size, enhanced absorbance and diffusance and low heat source without formaldehyde residuals. The CPP plays a certain role of resisting the novel A H1N1 influenza viruses, and especially, the effect of the NCP is more obvious.

The invention relates to a traditional Chinese medical oral liquid used for curing enteritis of poultries and cattle, which comprises three medicaments of potentilla, ash bark and phellodendron. The medical oral liquid is suitable for curing infection of digestive canal of poultries and cattle and curing the enteritis caused by germs and virus. Based on the fact that the specific physiological structure of the poultries can not digest wood fibre owing to the short genital tracts, the medicaments are made into a dosage form of oral liquid which can be dispersed in water and can be taken by sick poultries through drinking water, thereby being convenient for absorbing, and achieving the purpose of taking effect rapidly.

The invention discloses a weeding composition containing glufosinate-ammonium and sulfonylurea herbicides. The weeding composition comprises glufosinate-ammonium an active ingredient A and an active ingredient B. A weight ratio of the ingredient A to the ingredient B is 200: 1 to 1: 1. The active ingredient B comprises a sulfonylurea compound with a structural formula (I). The weeding composition comprises 5-80wt% of the active ingredients and the balance auxiliary agents. The weeding composition can be processed to form wettable powder, water dispersible granules, a water suspending agent and an oil suspending agent, can be used for preventing and removing weeds, has effects better than that of single glufosinate-ammonium or active ingredient B, reduces a pesticide usage dosage, reduces pesticide-caused unfavorable influence on the ecological environment, has good preventing effects on cyperaceous weeds such as Cyperus rotundus difficultly removed by glufosinate-ammonium and can effectively treat weed resistance to herbicides.

The invention discloses an agricultural bactericidal composition containing bupirimate and azoxystrobin. The agricultural bactericidal composition is prepared from effective components including the bupirimate and the azoxystrobin. The agricultural bactericidal composition solves the problem of insecticide resistance caused by long-term use of single doses of two products, namely the bupirimate and the azoxystrobin separately, and a mixture of the bupirimate and the azoxystrobin has the obvious synergism on controlling powdery mildew.

The invention belongs to the technical field of medicines, and specifically relates to a suppository for treating mammal endometritis. The preparation disclosed in the invention comprises the following components of: by weight, 0.004-0.01% of staphylococcus lysozyme, 0.1-4% of lysozyme, 10-80% of semisynthetic fatty glyceride, 1-20% of poloxamer 188(F68), 1-20% of HPMC, 5-50% of sodium bicarbonate and 5-50% of sodium dihydrogen phosphate. After the preparation provided by the invention enters into mammal uterus through administration, the preparation can undergo effervescence decomposition in a body fluid. The medicine is mixed in foams and rapidly released. Contact area between the medicine and mucosal of uterus becomes larger and the medicine can penetrate into deep portions of mucosa wrinkles so as to prolong the action time between the medicine and the mucosa, raise the concentration of the medicine on local tissues, further enhance the curative effect and effectively kill various pathogens which can cause endometritis.

The invention discloses a biological antibacterial polypeptide preparation as well as a preparation method and application of the biological antibacterial polypeptide preparation. The biological antibacterial polypeptide preparation takes water as a carrier and is prepared from the following components in percentage by weight: 0.1 percent to 10 percent of a biological antibacterial peptide BQ and 0.01 percent to 1 percent of polyhexamethylene biguanidine. The biological antibacterial polypeptide preparation has good sterilization effect. A core sterilization component of the preparation is a novel antibacterial peptide and has very high sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. When an in-vitro experiment is carried out for 2min to 5min, 99.9 percent of sterilization rate can be realized. The biological antibacterial polypeptide preparation has high safety, has no toxicity to or residues to human bodies, has high stability and can be used as a prevention medicine. The main acting component is a biological preparation and the disadvantages that a traditional chemical preparation has irritation on mucosa and bacteria easily have drug resistance are overcome. The biological antibacterial polypeptide preparation is easily accepted by organisms, has no toxic side effect and is suitable for long-time utilization or used as the prevention medicine.

The invention relates to a Chinese medicinal granular formulation for increasing egg production of poultry which is prepared from 9 Chinese medicinal materials including astragalus, japanese teasel, atractylodes, eucommia bark, white peony root, psoralea fruit, Chinese yam, jujube, villous amomum. The medicament has effects of clearing away heat and toxic material, resolving dampness and fortifying the spleen, supplying qi and strengthening yang that is mainly used for treating egg production reduced and recovering egg production capability, can increase egg production and delay egg production fastigium. At the same time, the medicament formulation is the granular formulation by considering special physiological structure of poultry that genital tract is short and can not digest wood fibre, and can be dispersed rapidly, the sick poultry takes medicament by drinking water which is convenient and is easy to absorb, and can get rapid effect.

The invention relates to a traditional Chinese medicine oral liquid used for curing hyperpyrexia of cattle, which comprises eight medicaments of honeysuckle, weeping forsythia, cortex moutan, dandelion, desmodium, bupleurum, prunella vulgaris and plaster. The invention has the function of heat-clearing and detoxifying, and purging intense heat and relaxing the bowels. Simultaneously, the dosage form of the medicaments are made into oral liquid which can be dispersed rapidly in drinking water, is taken by sick cattle through drinking water, thus being convenient for absorbing and achieving the purpose of taking effect rapidly.

The invention relates to an application of a Coryebacterium parvum preparation (CPP) or an non-cell Coryebacterium parvum preparation (NCPP) in the pharmaceutical field, and especially relates to the application in preparing medicaments for treating virus hepatitis B infection, and the application of the CPP / NCPP combined with a hepatitis B immunoglobulin (HBIG) or an anti-hepatitis B immunoglobulin (humanized / human anti-HBs) in preparing the medicaments for treating virus hepatitis B infection. The CPP is a preparation which is prepared through inactivating the CP with formaldehyde, and the CPP has the characteristics of nanometer level, uniform particle size, high absorption degree and diffusion degree, low heat source and no formaldehyde residual; and the CPP has a certain effect for resisting virus hepatitis B infection, and the NCPP has an obvious effect, and the CPP / NCPP combined with the HBIG / HBs has a more obvious effect.

The invention discloses a pesticide composition for controlling banana thrips. The composition includes active ingredients and auxiliary agents, and the active ingredients include d-limonene and diethyl aminoethyl hexanoate. The active ingredient accounts for 2.5% to 12% of the total weight of the pesticide composition. The invention finds that diethyl aminoethyl hexanoate has a preventive and control effect on banana thrips, and the compounding of d-limonene and diethyl aminoethyl hexanoate has obvious synergistic effect, and the control effect on banana thrips is better than the single component of diethyl hexanoate and d-limonene Control effect on banana thrips.

The invention discloses a formula of a traditional Chinese medicine for preventing and curing chicken diseases and relates to the technical field of formula for preventing and curing the chicken diseases. The formula is prepared from the following raw materials: 0.4-0.5g of herba portulacae, 0.4-0.8g of radix isatidis, 0.20-0.50g of shiny chinquefoil herbs, 0.05-0.16g of tangerine peels and 0.05-0.16g of fructus crataegi. The formula is a pure traditional Chinese medicine formula, has obvious curative effect on preventing and curing gastrointestinal diseases and virus communicable diseases of chicken, overcomes the disadvantage that the chicken are liable to have drug resistance after being treated by western drugs, does not have side and toxic effects, is obvious in effect of promoting growth action of the chicken, is available in materials and lower in cost and can be popularized and applied in a large range.

The invention relates to a traditional Chinese medicine hemsleya root and also discloses an extraction method of hemsleyadin, the method is used for extracting the hemsleyadin, and the extraction method has simple method, low cost and high yield. The hemsleyadin can be made into various formulations according to the needs, such as oral liquid, tablets, injection, and the like, thereby being used for treating bacterial diseases of livestock and poultry, having good efficacy, overcoming the defects that the use of antibiotics for treating the bacterial diseases is easy to generate the drug resistance and easy to have residues in vivo as well as being widely applied in livestock breeding and production.

The invention belongs to the technical field of medicines, and particularly relates to an effervescent suppository for treating mammal vaginitis. A preparation disclosed by the invention consists of the following components in percentage by weight: 0.01-0.04 percent of recombinant lysostaphin, 10-50 percent of lactose, 5-30 percent of microcrystalline cellulose, 1-20 percent of polyoxyl[40]stearate, 1-10 percent of povidone, 5-40 percent of sodium bicarbonate, 5-40 percent of sodium dihydrogen phosphate and 0.1-5 percent of superfine silica powder. The preparation can disintegrate in an effervescent manner in the presence of body fluid after entering the vagina of a mammal, and medicaments are released rapidly by being mixed in foam, so that the contact area between the medicaments and vaginal mucosa is increased, the medicaments can permeate deep into mucosa folds, the acting time of the medicaments on mucosa is prolonged, the local tissue medicament concentration is increased, the treatment effect is enhanced, and various pathogenic bacteria causing vaginitis are killed effectively.

The invention relates to a weeding composition containing ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and cyhalofop-butyl and relates to the technical field of production of weedicide. Effective components comprise the ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and the cyhalofop-butyl. The weight part ratio of the ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime to the cyhalofop-butyl in the weeding composition ranges from (1 to 0.1) to (1 to 20). The ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and the cyhalofop-butyl are compounded so that the weeding composition has the effect of preventing and controlling weeds of paddy rice fields in an efficient and broad-spectrum manner; meanwhile, a weed control spectrum range is expanded; the weeding composition has a prevention and controleffect on various weeds of direct seeding paddy rice fields, such as barnyard grass, green bristlegrass, monochoria vaginalis, ammannia baccifera, ludwigia prostrate, rotala indica, digitaria sanguinalis, leptochloa chinensis, cyperus rotundus and sirpus yagara; the weeding composition has no influences on crops and the effect is better than that of single utilization of two weedicide varieties including the ethanone,1-[3-(trifluoromethyl)phenyl]-o-[2,6-bis[(4,6-dimethoxy-2-pyrimidinyl)oxy]benzoyl]oxime and cyhalofop-butyl.

The invention relates to a traditional Chinese oral liquid for curing broiler ascites, which comprises nine medicaments of atractylodes, tuckahoe, umbellate pore furgus, areca peel, papaya, radix aucklandiae, amomum, semen pharbitidis and radix codonopsitis. The combination of the nine medicaments in the medicament prescription has the effects of replenishing qi to invigorate the spleen and inducing diuresis and excreting dampness, and quickening blood circulation, strengthening the oxygen carrying capacity of erythrocyte according to causes of the broiler ascites, and has the functions of reducing high pressure of lungs, increasing the oxygen supply and improving the organism immunity. Simultaneously, the formulation of the medicament combines the special physiological structure that genital tracts of poultry are short and can not digest wooden fibers to prepare the medicaments to be the oral liquid that can be dispersed quickly in the feeding water, and sick animals can take medicines by drinking water, of which is convenient and beneficial to absorb, thus achieving the purpose of quick effect.

The invention discloses an agricultural bactericidal composition containing bupirimate and azoxystrobin. The agricultural bactericidal composition is prepared from effective components including the bupirimate and the azoxystrobin. The agricultural bactericidal composition solves the problem of insecticide resistance caused by long-term use of single doses of two products, namely the bupirimate and the azoxystrobin separately, and a mixture of the bupirimate and the azoxystrobin has the obvious synergism on controlling powdery mildew.