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A kind of effervescent suppository for treating mammalian vaginitis

A technology for mammals and vaginitis, applied in the direction of suppository delivery, drug combination, medical preparations of non-active ingredients, etc., can solve the problems of unfavorable penetration into the vaginal mucosa, small drug distribution area, weak interaction, etc., and achieve bactericidal effect Strong, rapid release, strong bactericidal effect

Active Publication Date: 2018-11-02
昆山博青生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a kind of biocidal effervescent suppository for mammalian vaginitis, to overcome the inconvenience of using in the prior art. The distribution area of ​​the drug in the vagina is small, the retention time is short, and the interaction with the liquefaction of the mucous membrane is weak, which is not conducive to penetration into the vaginal mucous membrane.

Method used

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  • A kind of effervescent suppository for treating mammalian vaginitis
  • A kind of effervescent suppository for treating mammalian vaginitis
  • A kind of effervescent suppository for treating mammalian vaginitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Recombinant lysostaphin effervescent suppository preparation method 1 (prescription 1)

[0029] 1. Composition and ratio

[0030] Recombinant Lysostaphin 0.01%, Lactose 50%, Microcrystalline Cellulose 30%, Polyoxyl 40 Stearate 1%, Povidone 5.99%, Sodium Bicarbonate 5%, Sodium Dihydrogen Phosphate 5%, Micropowder Silicone 3%.

[0031] 2. Preparation

[0032] Weigh 0.01 g of recombinant lysostaphin, 50 g of lactose, 30 g of microcrystalline cellulose, 1 g of polyoxyl 40 stearate, 5.99 g of povidone, 5 g of sodium bicarbonate, 5 g of sodium dihydrogen phosphate, and 3 g of micropowdered silica gel. The above raw materials are crushed and passed through an 80-mesh sieve, mixed evenly, and pressed into shape.

Embodiment 2

[0033] Embodiment 2 Recombinant lysostaphin effervescent suppository preparation method 2 (prescription 2)

[0034] 1. Composition and ratio

[0035] Recombinant Lysostaphin 0.02%, Lactose 20%, Microcrystalline Cellulose 5%, Polyoxyl 40 Stearate 9.88%, Povidone 10%, Sodium Bicarbonate 40%, Sodium Dihydrogen Phosphate 15%, Micropowder Silica gel 0.1%.

[0036] 2. Preparation

[0037] Weigh 0.02g of recombinant lysostaphin, 20g of lactose, 5g of microcrystalline cellulose, 9.88g of polyoxyl 40 stearate, 10g of povidone, 40g of sodium bicarbonate, 15g of sodium dihydrogen phosphate, and 0.1g of micropowder silica gel . The above raw materials are crushed and passed through an 80-mesh sieve, mixed evenly, and pressed into shape.

Embodiment 3

[0038] Embodiment 3 Recombinant lysostaphin effervescent suppository preparation method 3 (formula 3)

[0039] 1. Composition and ratio

[0040] Recombinant Lysostaphin 0.04%, Lactose 10%, Microcrystalline Cellulose 11.96%, Polyoxyl 40 Stearate 20%, Povidone 1%, Sodium Bicarbonate 12%, Sodium Dihydrogen Phosphate 40%, Micropowder Silicone 5%.

[0041] 2. Preparation

[0042] Weigh 0.04 g of recombinant lysostaphin, 10 g of lactose, 11.96 g of microcrystalline cellulose, 20 g of polyoxyl 40 stearate, 1 g of povidone, 12 g of sodium bicarbonate, 40 g of sodium dihydrogen phosphate, and 5 g of micropowdered silica gel. The above raw materials are crushed and passed through an 80-mesh sieve, mixed evenly, and pressed into shape.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to an effervescent suppository for treating mammal vaginitis. A preparation disclosed by the invention consists of the following components in percentage by weight: 0.01-0.04 percent of recombinant lysostaphin, 10-50 percent of lactose, 5-30 percent of microcrystalline cellulose, 1-20 percent of polyoxyl[40]stearate, 1-10 percent of povidone, 5-40 percent of sodium bicarbonate, 5-40 percent of sodium dihydrogen phosphate and 0.1-5 percent of superfine silica powder. The preparation can disintegrate in an effervescent manner in the presence of body fluid after entering the vagina of a mammal, and medicaments are released rapidly by being mixed in foam, so that the contact area between the medicaments and vaginal mucosa is increased, the medicaments can permeate deep into mucosa folds, the acting time of the medicaments on mucosa is prolonged, the local tissue medicament concentration is increased, the treatment effect is enhanced, and various pathogenic bacteria causing vaginitis are killed effectively.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to an effervescent suppository for treating vaginitis in mammals. Background technique [0002] Sow vaginitis is a common and multiple reproductive organ disease in pig production. The main causes of this disease are postpartum vaginal damage, artificial insemination and disinfection, sow vaginal damage during natural mating, and pathogenic microorganisms through Various ways of infection can cause vaginitis. Sows suffering from vaginitis will cause reduced lactation or no milk after delivery, so that the piglets will not get enough milk, which will affect the growth and development of the piglets. After weaning, sows will not be in estrus due to vaginal inflammation or will not match repeatedly after estrus. Even if they are occasionally matched, they will produce weak piglets, stillbirths, mummies or false pregnancies, which will affect the normal performance of sows' reproductive ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/47A61K9/02A61K47/38A61P15/02
Inventor 黄青山汪益涵李国栋蒋司嘉
Owner 昆山博青生物科技有限公司
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