Biological antibacterial polypeptide preparation, preparation method and application thereof

A technology of antibacterial peptides and antibacterial peptides, which can be used in botanical equipment and methods, topical antibacterial agents, chemicals for biological control, etc. Long-term use and preventive use, etc., to achieve the effect of good sterilization effect, strong sterilization effect, and good sterilization effect

Active Publication Date: 2019-07-05
昆山博青生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the sensitivity of these parts, the requirements for therapeutic drugs are higher. The common existing disinfectants can irritate the skin and mucous membranes, the antibacterial spectrum is not wide enough, or the antibacterial mechanism itself may easily lead to bacterial resistance. It is not suitable for long-term use and prevention. use, existing disinfectants have many shortcomings and cannot meet the above requirements

Method used

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  • Biological antibacterial polypeptide preparation, preparation method and application thereof
  • Biological antibacterial polypeptide preparation, preparation method and application thereof
  • Biological antibacterial polypeptide preparation, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Composition and ratio: (weight percentage)

[0034] Biological antimicrobial peptide BQ 0.1%; polyhexamethylene biguanide (PHMB) 1%; glycine 1%; chitosan 1%; glycerol 1%; potassium dihydrogen phosphate 1%; disodium hydrogen phosphate 1%; sodium chloride 0.1%; the rest uses distilled water.

[0035] 2. Preparation steps

[0036] (1) Dissolve potassium dihydrogen phosphate and disodium hydrogen phosphate in distilled water to obtain solution A;

[0037] (2) According to the formulation prescription, weigh the required biological antimicrobial peptide BQ, polyhexamethylene biguanide and glycine, add them to the part A solution, stir and dissolve to obtain solution B.

[0038] (3) Weigh chitosan and sodium chloride in distilled water according to the ratio to obtain solution C;

[0039] (4) After mixing the above solution B and solution C, add glycerin and stir evenly to obtain the finished product.

[0040] It can be divided into plastic or glass bottles and used directly as a dis...

Embodiment 2

[0042] 1. Composition and ratio: (weight percentage)

[0043] Biological antimicrobial peptide BQ 10%; polyhexamethylene biguanide (PHMB) 0.01%; glycine 8%; chitosan 10%; glycerol 5%; potassium dihydrogen phosphate 20%; disodium hydrogen phosphate 30%; sodium chloride 2%; the rest is distilled water, the total weight percentage of each component is 100%.

[0044] 2. The preparation method is the same as in Example 1;

[0045] It can be divided into plastic or glass bottles and used directly as a disinfectant; it can also be divided into spray bottles with a manual pump to prepare a disinfectant spray; it can also be used as a wet wipe additive to absorb into non-woven fabrics to make it hygienic Wet wipes.

Embodiment 3

[0047] 1. Composition and ratio

[0048] Biological antimicrobial peptide BQ 2%; polyhexamethylene biguanide (PHMB) 0.02%; glycine 2%; chitosan 2%; glycerol 3%; potassium dihydrogen phosphate 10%; disodium hydrogen phosphate 20%; sodium chloride 1%; the rest is distilled water, the total weight percentage of each component is 100%.

[0049] 2. The preparation method is the same as in Example 1.

[0050] It can be divided into plastic or glass bottles and used directly as a disinfectant; it can also be divided into spray bottles with a manual pump to prepare a disinfectant spray; it can also be used as a wet wipe additive to absorb into non-woven fabrics to make it hygienic Wet wipes.

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Abstract

The invention discloses a biological antibacterial polypeptide preparation as well as a preparation method and application of the biological antibacterial polypeptide preparation. The biological antibacterial polypeptide preparation takes water as a carrier and is prepared from the following components in percentage by weight: 0.1 percent to 10 percent of a biological antibacterial peptide BQ and 0.01 percent to 1 percent of polyhexamethylene biguanidine. The biological antibacterial polypeptide preparation has good sterilization effect. A core sterilization component of the preparation is a novel antibacterial peptide and has very high sterilization effect on staphylococcus aureus, escherichia coli, candida albicans and viruses. When an in-vitro experiment is carried out for 2min to 5min, 99.9 percent of sterilization rate can be realized. The biological antibacterial polypeptide preparation has high safety, has no toxicity to or residues to human bodies, has high stability and can be used as a prevention medicine. The main acting component is a biological preparation and the disadvantages that a traditional chemical preparation has irritation on mucosa and bacteria easily have drug resistance are overcome. The biological antibacterial polypeptide preparation is easily accepted by organisms, has no toxic side effect and is suitable for long-time utilization or used as the prevention medicine.

Description

Technical field [0001] The invention relates to an antibacterial peptide preparation, a preparation method and its application. Background technique [0002] At present, the clinical infection is quite serious, and it has become a major killer threatening human health in the past 20 years. Moreover, more and more bacteria can withstand antibiotic treatment, which poses a serious threat to public health. In the United States, more lives were lost in 1998 due to drug-resistant bacterial infections than on the battlefield in Vietnam. Bacteria that can be killed by antibiotics once easily, such as: Staphylococcus aureus, pneumococcus, Pseudomonas aeruginosa, Candida albicans, Escherichia coli, etc., are now becoming more and more aggressive due to the development of drug resistance. More and more helpless. Among them, drug-resistant Staphylococcus aureus is the most active molecule. The infection caused by it not only has poor efficacy or completely ineffective under conventional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N47/44A01N43/50A01P1/00A61K38/10A61P31/02A61K31/785
CPCA01N43/50A01N47/44A61K31/785A61K38/10A01N2300/00A61K2300/00Y02A50/30
Inventor 叶贵子黄青山
Owner 昆山博青生物科技有限公司
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