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Gel and preparation method thereof

A gel and thickener technology, applied in the field of gel and its preparation, can solve the problems of difficult molecular structure control, reduce gel swelling, high toxicity, etc., achieve the effect of reducing cost, reducing pain, and avoiding secondary surgery

Active Publication Date: 2021-06-22
JIANGSU DISSUETECH MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is a gel formed by mixing PEG-SG with an electrophilic component (Tri-Lysis and polyethyleneimine (PEI)). The electrophilic component is composed of Tri-Lysis and PEI. Tri-Lysis can reduce the swelling of the gel , PEI can increase the speed of gelation, but PEI itself is highly toxic, and its molecular structure is not easy to control. Although it has been approved as a medical device, it still needs to pay attention to the dosage and location when applying

Method used

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  • Gel and preparation method thereof
  • Gel and preparation method thereof
  • Gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Raw materials: 4-arm-PEG-SG (purchased from SINOPEG, molecular weight 20,000), ε-PL (purchased from Zhengzhou Bainafu, model E-PLA, degree of polymerization 25-35), HPMC (purchased from Xi’an Tianzheng, molecular weight The range is 10000-1500000, the viscosity is 30000).

[0045] Neutral phosphate buffer: composed of 0.85% wtNaCl, 0.05% wtNa 2 HPO 4 and 0.015% wtNaH 2 PO 4 It is formulated with water for injection, put into a transparent vial after passing through a 0.22μm filter membrane, and then sterilized under high pressure and humidity after sealing.

[0046] Fundus sealant kit:

[0047] Component 1: It consists of a brown sealed vial (sterilized by overall irradiation) filled with 40mg 4-arm-PEG-SG, ready for immediate use. When in use, take 0.5mL of neutral phosphate buffer solution and inject it into the above-mentioned brown bottle, shake it gently to dissolve it, and then draw out the solution with a syringe for use.

[0048] Component 2: It consists o...

Embodiment 2

[0052] The difference from Example 1 is that Component 1 contains 30mg 4-arm-PEG-SG, and Component 2 contains 0.5mgε-PL and 8mg HPMC.

Embodiment 3

[0054] The difference from Example 1 is that Component 1 contains 60mg 4-arm-PEG-SG, and Component 2 contains 3.5mgε-PL and 15mg HPMC.

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Abstract

The invention discloses gel and a preparation method thereof, and belongs to the field of tissue material engineering. The gel is prepared from active substances comprising the following three components, wherein the first component is PEG (Polyethylene Glycol) modified by N-hydroxysuccinimide-glutaric acid ester; the second component is polylysine; and the third component is a thickening agent. The active substance does not include amino-modified polyethylene glycol and amino-modified polyoxyethylene derivatives. The swelling property of the gel disclosed by the invention can keep low swelling and low shrinkage in a range of up to 180 days, which is a key factor for ophthalmology use because if the swelling rate of the vitreous body substitute is high, intraocular pressure can be increased to cause glaucoma, and if the swelling rate of the fundus gel is high, the retina can be pulled to cause retinal detachment.

Description

technical field [0001] The invention belongs to the field of tissue material engineering, and in particular relates to a gel and its preparation method and application. Background technique [0002] As a tissue engineering material, hydrogel is widely used in medicine, involving many applications such as anti-adhesion materials, hemostatic materials, filling scaffolds for bone defect repair, tissue adhesives, slow-release drug carriers, and antibacterial and anti-infection dressings. Polyethylene glycol (PEG) occupies a place in commercial biomaterials due to its good biocompatibility, adjustable molecular weight, narrow molecular weight distribution, and good stability between batches of raw materials. The terminal of PEG has a hydroxyl group. Through chemical reaction, the terminal group of PEG can be modified conveniently, such as carboxyl, amino, mercapto, methyl, etc. On the other hand, with the popularization of the concept of minimally invasive surgery, on the basis ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26A61L27/52A61L27/50A61L31/04A61L31/06A61L31/14
CPCA61L27/26A61L27/52A61L27/50A61L31/041A61L31/145A61L31/14A61L2430/16C08L71/02C08L1/02C08L77/04
Inventor 曹彬吴亮亮朱健
Owner JIANGSU DISSUETECH MEDICAL TECH CO LTD
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