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Application of lactobacillus johnsonii BS15 in preparation of medicine for preventing and/or treating intestinal injury caused by chronic fluorine poisoning

A technology of Lactobacillus johnsonii and intestinal damage, applied in the directions of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as no research report, increase fecal fluoride discharge, etc. The effect of bacterial flora structure, promoting secretion and reducing adhesion

Pending Publication Date: 2021-06-25
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, serpentine often contains asbestos, which is a human carcinogen, and its use safety has always been controversial; aluminum is a powerful complexing agent for fluorine, and 40% to 60% of the fluorine in the intestinal tract can be absorbed by aluminum. Combined, small doses of aluminum hydroxide can increase excretion of fecal fluoride
However, no studies have ever reported a link between L. johnsonii and the prevention and treatment of intestinal damage from chronic fluorosis

Method used

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  • Application of lactobacillus johnsonii BS15 in preparation of medicine for preventing and/or treating intestinal injury caused by chronic fluorine poisoning
  • Application of lactobacillus johnsonii BS15 in preparation of medicine for preventing and/or treating intestinal injury caused by chronic fluorine poisoning
  • Application of lactobacillus johnsonii BS15 in preparation of medicine for preventing and/or treating intestinal injury caused by chronic fluorine poisoning

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The present invention adopts 30 3-week-old male ICR mice to carry out the feeding experiment. The experimental design flow chart is as figure 1 ,Depend on figure 1 It can be seen that the adaptation period of the mice is 7 days, and the trial period is 98 days (that is, 14 weeks). During the 14 weeks after the beginning of the trial period, the mice in the high-fluorine drinking water + probiotic group were fed with Lactobacillus johnsonii BS15 bacteria Mice in the control group and high-fluorine drinking water group were fed with PBS buffer (pH7.0), and each group was fed with purified water; from the 35th day of the experiment to the end, the high-fluorine drinking water group and high The rats in the group were fed high-fluoride water with a fluorine (NaF) content of 100 mg / L, and other conditions remained unchanged.

[0039] The specific experimental groups and feeding methods are shown in Table 1. They were divided into control group, high fluoride drinking water...

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Abstract

The invention belongs to the technical field of microorganism application, and provides application of lactobacillus johnsonii BS15 in preparation of a medicine for preventing and / or treating intestinal injury caused by chronic fluorine poisoning. The lactobacillus johnsonii BS15 is preserved in the China Center for Type Culture Collection on December 13, 2013, the preservation address is Wuhan University, Wuhan, China, and the preservation number is CCTCC NO: M2013663. The intake of the lactobacillus johnsonii BS15 significantly reduces the adverse effects of chronic fluorine poisoning on intestinal flora, intestinal tissue development and intestinal wall permeability, promotes the secretion of tight junction proteins of intestinal epithelial cells, reduces the adhesion of pathogenic bacteria to the intestinal epithelial cells, and improves the intestinal microbial ecological environment and the intestinal flora structure.

Description

technical field [0001] The invention relates to the technical field of microorganism application, in particular to the application of Lactobacillus johnsonii BS15 in the preparation of drugs for preventing and / or treating intestinal damage caused by chronic fluorosis. Background technique [0002] As one of the halogen elements, fluorine is extremely active in chemical properties. It is a trace element necessary for the normal growth of humans and other animals. Appropriate amount of fluorine can effectively enhance the hardness of the body's bones and teeth, promote the excitability of the nervous system, and promote the normal biological activity of certain enzymes. But if the body takes in too much fluoride, it will inevitably cause fluorosis. Long-term excessive intake of fluoride not only causes dental fluorosis and skeletal fluorosis, but also causes soft tissue damage, such as spinal cord, heart, liver, lung, kidney and brain damage. [0003] At present, there is no...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P1/00
CPCA61K35/747A61P1/00
Inventor 倪学勤曾东辛金鸽王鹤松孙宁
Owner SICHUAN AGRI UNIV
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