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Polygonatum sibiricum galactan and preparation method and application thereof

A technology of galactan and Polygonatum, which is applied in the fields of food and medicine, can solve problems such as insufficient depth of research on Polygonatum, slow progress in research on plant polysaccharides, and complex components of plant polysaccharides, so as to inhibit the reproduction of harmful bacteria and promote intestinal probiotics Group activity, beneficial effect on survival

Active Publication Date: 2021-06-25
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to provide a Polygonatum galactan and its preparation method and application in view of the insufficient depth of research on Polygonatum Polygonatum, complex plant polysaccharide components in Polygonatum Polygonatum, and slow progress in the research on plant polysaccharides in Polygonatum Polygonatum.

Method used

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  • Polygonatum sibiricum galactan and preparation method and application thereof
  • Polygonatum sibiricum galactan and preparation method and application thereof
  • Polygonatum sibiricum galactan and preparation method and application thereof

Examples

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preparation example Construction

[0060] The preparation method of the above-mentioned Polygonatum galactan according to an embodiment of the present invention comprises the following steps S1-S2:

[0061] S1: Extract polysaccharides processed from plants of the genus Polygonatum.

[0062] S2: purifying components with a weight average molecular weight of 4000Da-15000Da in Polygonatum polysaccharide to obtain Polygonatum galactan.

[0063] Further, the processed raw material of the Polygonatum genus is processed Polygonatum (or called Polygonatum processed product).

[0064] In a specific example, plants of the genus Polygonatum include but are not limited to Polygonatum Polygonatum, Polygonatum yunnanensis, Polygonatum multiflora, Polygonatum barbata, Polygonatum odoratum, Polygonatum kangding, Polygonatum polygonatum, Polygonatum trichomes, Polygonatum longifolia, Polygonatum longifolia, Polygonatum longifolia Polygonatum stalk, Rhizoma Polygonatum, Rhizoma Polygonatum, Rhizoma Polygonatum Dianhua, Rhizoma ...

Embodiment 1

[0096] The extraction and purification of embodiment 1 Polygonatum galactan

[0097] 1. Extraction of Polygonatum Polysaccharides

[0098] Remove impurities and fibrous roots of 10kg of fresh Polygonatum multiflora, wash and dry, and cut into thick slices. Then put it in a steamer. After the water in the steamer boils, turn down the power of the steamer, start timing, and steam for 6 hours. After steaming, the Polygonatum is taken out, placed in a 70°C oven, and taken out after 12 hours is steamed and sun-dried Polygonatum. Repeat the above method to obtain "nine steams and nine suns" Polygonatum.

[0099] Take 200 g of Polygonatum multiflora processed above, extract twice with 10 times water reflux, filter, combine extracts, centrifuge to obtain supernatant, and concentrate to obtain 1300 mL concentrate. Add 945 mL of 95% ethanol until the alcohol concentration is 40%, and centrifuge (4000 rpm×15 min) to obtain 40% alcohol precipitate and supernatant. Under stirring, add ...

Embodiment 2

[0102] Example 2 Structural Analysis of Polygonatum Galactan

[0103] 1. Experimental process

[0104] 1.1. Molecular weight and its distribution

[0105] The molecular weight and distribution of Polygonatum galactan prepared in Example 1 were analyzed by high performance gel exclusion chromatography-differential detector detection method (HPGPC-RI).

[0106] Chromatography instrument: Agilent technologies 1260series high performance liquid chromatography;

[0107] Chromatographic conditions: Shodex Ohpak SB-804HQ (7.8mm×300mm) column; column temperature is 35°C; differential detector; mobile phase is 0.1M NaCl, flow rate is 0.5mL / min;

[0108] Determination process: Take 5 mg of galactan sample or dextran reference substance of known molecular weight and prepare a 5 mg / mL solution with mobile phase, pass through a 0.22 μm microporous membrane, and enter 50 μL of the filtrate into a high-performance liquid chromatograph for analysis. Record the chromatogram. The data is pr...

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Abstract

The invention relates to polygonatum sibiricum galactan and a preparation method and application thereof. The polygonatum sibiricum galactan has a structure represented by a general formula I which is described in the specification. In the formula (I), n represents the number of sugar repeating units, and n is a natural number. In the general formula structure of the polygonatum sibiricum galactan, a beta (1-> 4) glucosidic bond is used as a main chain, and side chain galactose is connected to the main chain through a beta (1-> 6) glucosidic bond. The polygonatum sibiricum galactan and a pharmaceutical composition containing the polygonatum sibiricum galactan have certain activity of promoting proliferation of probiotics, so that the polygonatum sibiricum galactan and the pharmaceutical composition containing the polygonatum sibiricum galactan have medical value in application to preparation of probiotics medicines.

Description

technical field [0001] The invention relates to the technical fields of food and medicine, in particular to a Polygonatum galactan and its preparation method and application. Background technique [0002] Polygonatum is a plant of the genus Polygonatum in the family Liliaceae, named for its tonic effect. Plants in this genus mainly include Polygonatum sibiricum, Polygonatum kingianum, Polygonatum cyrtonema, Polygonatum cathcartii, Polygonatum odoratum, Polygonatum prattii, Polygonatum pratii Polygonatum humile, Polygonatum minflatum, Polygonatum curvistylum, Polygonatum desoulayi, Polygonatum filipes, Polygonatum hirtellum, Polygonatum megaphyllum ), Polygonatum punctatum, Polygonatum altelobatum, Polygonatum alternicirrhosum, Polygonatum franchetii, Polygonatum hookeri, Polygonatum volucratum, Polygonatum nodosum, Polygonatum ppositifolium, Polygonatum zanlanscianense, Polygonatum tessellatum, Polygonatum acuminatifolium, Polygonatum cirrhifolium, Polyacgonatum grile , P...

Claims

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Application Information

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IPC IPC(8): C08B37/00A23L33/125A61K31/715A61K9/02A61P1/14A61P1/00A61K36/8969A61K125/00
CPCC08B37/0003C08B37/0036A61K31/715A61K9/02A61P1/14A61P1/00A61K36/8969A23L33/125A23V2002/00A23V2200/32A23V2250/51A23V2250/21A23V2250/5118A23V2250/161A23V2250/1628A23V2250/628Y02A50/30
Inventor 彭腾吴明一张军银罗兰周志鹏杨莲陈胡兰
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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