Collagenase inhibitor, eye essence containing collagenase inhibitor and preparation method of eye essence

A collagenase and inhibitor technology, applied in the field of cosmetics, can solve the problems of difficulty in reaching the dermis layer and the molecular weight of hydrolyzed collagen is large, and achieve the effects of excellent inhibitory effect, improved skin elasticity and simple operation.

Pending Publication Date: 2021-06-29
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the existing technology, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin etc., the present invention firstly provides a collagenase inhibitor and a preparation method thereof

Method used

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  • Collagenase inhibitor, eye essence containing collagenase inhibitor and preparation method of eye essence
  • Collagenase inhibitor, eye essence containing collagenase inhibitor and preparation method of eye essence
  • Collagenase inhibitor, eye essence containing collagenase inhibitor and preparation method of eye essence

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preparation example Construction

[0043]The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the Rhodiola rosea extract and the chamomile extract are uniformly mixed in a conventional mixing manner.

[0044] Collagenase

[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maintain th...

Embodiment

[0098] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0099] The extract of Rhodiola rosea was purchased from: Kunming Qiancao Biotechnology Co., Ltd.;

[0100] Chamomile extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0106] Provides Rhodiola rosea extract and chamomile extract as collagenase inhibitors. With Rhodiola rosea extract and chamomile extract by mass ratio 1:1 (embodiment 1), 1:10 (embodiment 2), 1:20 (embodiment 3), 1:25 (embodiment 4), After mixing at 1:30 (Example 5), the collagenase inhibitor was obtained.

[0107] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0108] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0109] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0110] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0111] The collagenase inhibitor of Example 5 was dissolved in 5 groups of deio...

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Abstract

The invention provides a collagenase inhibitor, eye essence containing the collagenase inhibitor and a preparation method of the eye essence. The collagenase inhibitor includes a rhodiola crenulata extract and a chamomile extract; and based on the total mass of the collagenase inhibitor, the addition of the rhodiola crenulata extract is 3-30%, and the addition of the chamomile extract is 70-97%. The collagenase inhibitor has excellent inhibition effects on the activity of collagenase, and has no side effects on human bodies.

Description

technical field [0001] The invention relates to a collagenase inhibitor, an eye essence containing the collagenase inhibitor and a preparation method thereof, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of sk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9711A61K8/9722A61K8/9789A61K8/9794A61K8/34A61K8/49A61K8/60A61K8/63A61K8/64A61K8/65A61K8/67A61K8/68A61K8/99A61Q19/00A61Q19/08
CPCA61K8/9789A61K8/9711A61K8/9722A61K8/645A61K8/68A61K8/65A61K8/99A61K8/9794A61K8/60A61K8/673A61K8/498A61K8/602A61K8/676A61K8/34A61K8/63A61Q19/005A61Q19/08A61K2800/782A61K2800/5922
Inventor 杨登亮谢佩佩李传茂张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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