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Beauty fluid, preparation method thereof and collagenase inhibitor

A beauty serum and collagenase technology, applied in skin care preparations, pharmaceutical formulas, cosmetic preparations and other directions, can solve problems such as difficulty, and achieve the effects of improving skin elasticity, easy raw materials, and mild formula

Pending Publication Date: 2021-06-29
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin, etc.

Method used

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  • Beauty fluid, preparation method thereof and collagenase inhibitor
  • Beauty fluid, preparation method thereof and collagenase inhibitor
  • Beauty fluid, preparation method thereof and collagenase inhibitor

Examples

Experimental program
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preparation example Construction

[0044] The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the pomegranate peel extract and the chamomile extract are uniformly mixed in a conventional mixing manner.

[0045] Collagenase

[0046] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis. Its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site. Co-regulate matrix metabolism and maintain the struc...

Embodiment

[0088] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0089] Red pomegranate peel extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.;

[0090] Chamomile extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0096] Provides pomegranate peel extract and chamomile extract as collagenase inhibitors. Red pomegranate peel extract and chamomile extract are by mass ratio 3:1 (embodiment 1), 2:1 (embodiment 2), 1:1 (embodiment 3), 1:2 (embodiment 4), 1 : 3 (embodiment 5) after mixing, obtain collagenase inhibitor.

[0097] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0098] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0099] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0100] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0101] The collagenase inhibitor of Example 5 was dissolved in 5 groups of deionized...

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PUM

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Abstract

The invention provides a beauty fluid, a preparation method thereof and a collagenase inhibitor. The beauty fluid comprises the collagenase inhibitor and a penetration enhancer; based on the total mass of the beauty fluid, the addition amount of the collagenase inhibitor is 0.01-10%; the addition amount of the penetration enhancer is 0.01-10%; the collagenase inhibitor comprises a pomegranate peel extract and a chamomile extract; and based on the total mass of the collagenase inhibitor, the addition amount of the pomegranate peel extract is 28-72%, and the addition amount of the chamomile extract is 28-72%. The beauty fluid provided by the invention is mild in formula, and can effectively improve skin elasticity, and thus, an effect of resisting aging is achieved.

Description

technical field [0001] The invention relates to a cosmetic liquid, a preparation method thereof and a collagenase inhibitor, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin collagen, increase the content ...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/00A61Q19/08
CPCA61K8/9789A61Q19/00A61Q19/08A61K2800/782A61K2800/5922
Inventor 杨登亮翟裕诗李传茂刘广健张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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