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Application of nanodiamond/TiO2 composite material in preparation of antitumor drugs

A nano-diamond and anti-tumor drug technology is applied in the application field of nano-diamond/TiO2 composite materials in the preparation of anti-tumor drugs, which can solve the problems of low chemical reactivity and harsh reaction conditions of nano-diamonds, and achieves enhanced chemical reactivity, Mild treatment conditions and reduced dependence effect

Active Publication Date: 2021-07-02
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, nano-diamonds are also superactive adsorbents and bioactive substance locators, which can greatly enhance the efficacy of drugs, but the chemical reactivity of nano-diamonds is low, and the required reaction conditions are harsh.

Method used

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  • Application of nanodiamond/TiO2 composite material in preparation of antitumor drugs
  • Application of nanodiamond/TiO2 composite material in preparation of antitumor drugs
  • Application of nanodiamond/TiO2 composite material in preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Nanodiamond / TiO 2 Preparation of composite materials

[0036] Take 0.9g of TiO 2 Disperse in a solution of 20ml ethanol and 40ml deionized water and stir continuously until the dispersion is uniform. At the same time, 0.1 g of nano-diamond powder was weighed, and added to the above solution, and continued to stir evenly. This solution is then transferred to a 100ml hydrothermal reaction kettle, reacted at 180°C for 3h, cooled to room temperature naturally, centrifuged, and dried at 60°C for 12h to obtain a nano-diamond / TiO 2 composite material.

[0037] (2) Nanodiamond / TiO 2 Characterization of Composite Materials

[0038] From figure 1 The SEM image shows that nanodiamond / TiO 2 Composite materials are small particles with a particle size below 100nm. figure 2 The XRD results show that nanodiamond / TiO 2 The material contains TiO 2 All diffraction peaks with nanodiamond, which indicates that in nanodiamond / TiO 2 Nanodiamond and TiO in Composite Material...

Embodiment 2

[0044] According to the method of Example 1, different amounts of raw materials are used to prepare nano-diamond / TiO with a nano-diamond doping amount of 1wt%. 2 Composite material (NDs-TiO 2 (1%)).

[0045] Characterized by the same characterization means as in Example 1 above, it can be seen that the nano-diamond / TiO prepared above 2 The particle size of the composite material is below 100 nm, and has similar specific killing activity to tumor cells as the composite material obtained in Example 1.

[0046] Figure 5 The doping amount is 1% nano-diamond / TiO 2 The cell activity test results of the composite material for normal cells (L929) and tumor cells (Hela). The results showed that under the condition of ordinary fluorescent lamp irradiation for 2 hours, the cell viability of tumor cells (Hela) decreased gradually with the increase of solution concentration, but the above phenomenon did not appear in normal organelles (L929).

Embodiment 3

[0048] According to the method of Example 1, using different amounts of raw materials, the preparation of nano-diamond / TiO with a nano-diamond doping amount of 5wt% 2 Composite material (NDs-TiO 2 (5%)).

[0049] Characterized by the same characterization means as in Example 1 above, it can be seen that the nano-diamond / TiO prepared above 2 The particle size of the composite material is below 100 nm, and has similar specific killing activity to tumor cells as the composite material obtained in Example 1.

[0050] Figure 6 Nanodiamond / TiO with nanodiamond doping amount of 5wt% 2 The cell activity test results of the composite material for normal cells (L929) and tumor cells (Hela). The results showed that under the condition of ordinary fluorescent lamp irradiation for 2 hours, with the increase of the solution concentration, the cell viability of the tumor cells (Hela) showed a gradient decline, and the cell morphology changed and decreased obviously. But in normal organ...

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Abstract

The invention discloses application of a nanodiamond / TiO2 composite material in preparation of antitumor drugs. In the application, the nanodiamond / TiO2 composite material is used for preparing the anti-tumor drugs, and the obtained anti-tumor drugs can specifically kill tumor cells under the irradiation condition of a fluorescent lamp (Philps Lifemax TLD 18W / 54-765 Cool Daylight); and the nanodiamond / TiO2 composite material has the advantages of being low in medicine dosage, free of biological toxic and side effects and mild in treatment conditions.

Description

technical field [0001] The invention relates to the technical field of nanometer medicine. More specifically, it relates to a nanodiamond / TiO 2 Application of composite materials in the preparation of antitumor drugs. Background technique [0002] With the development of economy and education, people pay more and more attention to the field of life and health, especially the diagnosis and treatment of cancer. How to effectively and specifically kill tumor cells is of great value. TiO 2 As a typical photocatalyst, semiconductor has been successfully commercialized, and its preparation cost is low, but its absorption utilization rate for visible light is extremely low. Photon diagnosis and treatment uses photons as information carriers or energy carriers to provide the possibility for cancer treatment from an optical point of view. At present, whether it is photon diagnosis or photon therapy, most of them use laser as the light source, and laser has high energy, which can ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/52A61P35/00B82Y5/00B82Y30/00
CPCA61K41/0057B82Y5/00B82Y30/00A61P35/00A61K47/52
Inventor 只金芳李佳胤刘润泽
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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