A kind of modified coconut shell activated carbon and its use in the preparation of pharmaceutical grade guanidine hydrochloride

A coconut shell activated carbon and modification technology, which is applied in the preparation of organic compounds, organic chemistry, chemical instruments and methods, etc., can solve the problems of large solubility gap, different content, limited production capacity, etc., and achieve high removal rate, good The effect of decolorization rate

Active Publication Date: 2022-07-12
石嘴山市鹏盛化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there are many types of impurities in this process, mainly including unreacted raw materials and cyanamide polymers generated by side reactions, the contents of various impurities are different, and the solubility gap is large. In order to ensure that various impurities, Such as the maximum possible removal of pigments, heavy metal ions, etc., the production capacity is severely limited

Method used

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  • A kind of modified coconut shell activated carbon and its use in the preparation of pharmaceutical grade guanidine hydrochloride
  • A kind of modified coconut shell activated carbon and its use in the preparation of pharmaceutical grade guanidine hydrochloride
  • A kind of modified coconut shell activated carbon and its use in the preparation of pharmaceutical grade guanidine hydrochloride

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preparation example Construction

[0033] Further, in some specific embodiments of the present invention, a kind of preparation method of modified coconut shell activated carbon, comprises:

[0034] Provide coconut shell raw materials, pulverize, sieve and dry the coconut shell raw materials to obtain pretreated coconut shell powder;

[0035] Mixing coconut shell powder with a phosphoric acid solution mixed with 27-hydroxyisomango alkyd, adding neohesperidin to the above solution, and soaking for 10 to 14 hours to obtain a soaking mixture;

[0036] The impregnated mixture is activated, cooled, washed, dried and ground in a muffle furnace to obtain modified coconut shell activated carbon.

[0037] Further, in some specific embodiments of the present invention, the molar ratio of neohesperidin to 27-hydroxyisomangiferic acid is 0.5-0.8:1.

Embodiment 1

[0039] A preparation method of modified coconut shell activated carbon, comprising:

[0040] Provide coconut shell raw materials, pulverize and sieve the coconut shell raw materials, select coconut shell powder with an average particle size of 15 meshes, and place it in a constant temperature blast drying oven at 105 ° C to dry for 14 hours to obtain pretreated coconut shell powder. body;

[0041] Phosphoric acid solution (45wt%) is mixed with above-mentioned coconut shell powder, wherein the ratio of phosphoric acid to coconut shell powder is 0.3mol:10g, then 27-hydroxyisomango alkyd is added thereto, stirring from time to time, and 27-hydroxyisomango alkyd is added thereto. The molar ratio of mango alkyd and phosphoric acid is 1:4, and the dipping mixture is obtained by dipping at room temperature for 12 hours;

[0042] The above impregnated mixture was placed in a muffle furnace for activation at 515°C for 3 hours, cooled to room temperature, washed with deionized water un...

Embodiment 2

[0044] A preparation method of modified coconut shell activated carbon, comprising:

[0045] Provide coconut shell raw materials, pulverize and sieve the coconut shell raw materials, select coconut shell powder with an average particle size of 10 meshes, and place it in a constant temperature blast drying oven at 110 ° C to dry for 12 hours to obtain pretreated coconut shell powder. body;

[0046] Phosphoric acid solution (40wt%) is mixed with above-mentioned coconut shell powder, wherein the ratio of phosphoric acid and coconut shell powder is 0.2mol:10g, then add 27-hydroxyisomango alkyd to it, and stir from time to time, 27-hydroxyisomango alkyd The molar ratio of mango alkyd and phosphoric acid was 1:5, and the dipping mixture was obtained by dipping at room temperature for 14 hours;

[0047] The above impregnated mixture was placed in a muffle furnace for activation at 480 °C for 1 h, cooled to room temperature, washed with deionized water until the pH of the solution wa...

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Abstract

The invention discloses a modified coconut shell activated carbon and its use in the preparation of pharmaceutical grade guanidine hydrochloride; a preparation method of the modified coconut shell activated carbon comprises: providing coconut shell raw materials, pulverizing, sieving and drying the coconut shell raw materials to obtain pretreated coconut shell powder; mix the coconut shell powder with a phosphoric acid solution mixed with 27-hydroxyisomango alkyd, and soak for 10-14 hours to obtain an impregnated mixture; place the impregnated mixture in a muffle furnace for activation , cooling, washing, drying and grinding to obtain modified coconut shell activated carbon. The modified coconut shell activated carbon prepared by the invention has developed pores, has larger specific surface area, total pore volume and microporosity, and has higher heavy metal removal rate and decolorization rate in the preparation of medical grade guanidine hydrochloride.

Description

technical field [0001] The invention belongs to the field of modified functional materials, in particular to a modified coconut shell activated carbon and its use in the preparation of pharmaceutical grade guanidine hydrochloride. Background technique [0002] Pharmaceutical grade guanidine hydrochloride is mainly used in the fields of protein and cell biology. It can be used to synthesize 2-aminopyrimidine, 2-amino-6-methylpyrimidine and 2-amino-4,6-dimethylpyrimidine. It is a pharmaceutical intermediate for the manufacture of sulfadiazine, sulfamethazine, sulfamethazine and other sulfa drugs, and can be used as a strong denaturant in the experiment of extracting RNA from cells. Due to the special requirements of its application field, the product has very high requirements for impurities. In addition to the conventional technical parameters such as content, melting point, pH, insoluble matter, moisture, etc., it also requires lower heavy metal content and pigment technical...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B32/324C01B32/342C07C277/06C07C279/02
CPCC01B32/324C01B32/342C07C277/06C07C279/02
Inventor 周鹏
Owner 石嘴山市鹏盛化工有限公司
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