Biological scaffold structure for strengthening bone regeneration as well as preparation method and application thereof
A bio-scaffold, bone regeneration technology, applied in the field of medicine, to achieve the effects of individualized treatment, good bone conduction and bone induction, and stable structural mechanical strength
Inactive Publication Date: 2021-07-13
THE PEOPLES HOSPITAL SHAANXI PROV
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Problems solved by technology
[0003] The technical problem to be solved by the present invention is to provide a biological scaffold structure for strengthening bone regeneration and its preparation method and application, which can solve the problem of early repair of critical size bone defects. The mechanical strength of the scaffold structure is stable, which can effectively induce bone regeneration and improve tissue microcirculation
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[0033] The enhanced bone regeneration scaffold material in the present invention is made of bioceramics, bioactive metals and growth factors with bone regeneration inducing ability, and is realized by 3D printing technology after three-dimensional modeling by means of a computer.
[0034] In this embodiment, the reinforced bone regeneration scaffold includes two parts: a biological scaffold and a regeneration element;
[0035] Such as figure 1 As shown in -8, from the perspective of the bioscaffold structure of the enhanced bone regeneration scaffold, the bioscaffold is a cylindrical structure with internal communicating holes, and the diameter and height of the bioscaffold can be determined according to the three-dimensional reconstruction data of the patient's bone defect in the previous CT scan.
[0036] The biological support (1) is provided with a vertical channel 101, a first transverse channel 102, a second transverse channel 103 and a release channel 104, and the verti...
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Abstract
The invention discloses a biological scaffold structure for strengthening bone regeneration and a preparation method and application thereof. The biological scaffold structure is firstly provided with arrayed vertical pore channels in the vertical direction of a biological scaffold and provided with transverse pore channels in the horizontal direction of the biological scaffold, so that the structural mechanical strength is stable, and the structure can be applied to long bone defect repair with the high mechanical strength requirement; secondly, the axis of the vertical pore channel and the axis of the transverse pore channel are eccentrically arranged without intersecting, the eccentric distance can be adjusted, then the pore channel gap degree is adjusted, and the structural strength is not affected, so that the pore channel gap degree of the reinforced bone regeneration stent can be controlled, and the structure can be applied to cancellous bone defect repair with low mechanical strength and high connectivity requirements, and the application range of all the bones in body is expanded; and finally, by virtue of filling of the regeneration element, growth factors can be slowly released;the biological scaffold structure has the capability of remarkably promoting bone regeneration, induces marrow mesenchymal stem cell chemotaxis and osteogenesis direction differentiation, and has good bone conduction and bone induction effects.
Description
technical field [0001] The invention relates to the field of medical technology, in particular to a biological scaffold structure for enhancing bone regeneration, its preparation method and application. Background technique [0002] Huge bone defect is one of the key and difficult problems faced by orthopedic surgeons. In clinical practice, autologous bone or artificial bone transplantation is often used as a repair method. The composite biological scaffold brought about by the development of bone tissue engineering provides a new method for the repair of bone defect. A solution with great potential. As the core element of tissue engineering, bio-scaffolds need to have a biomimetic microstructure required for tissue repair while having a certain mechanical strength, involving many factors such as material type, intercommunicating pore diameter, and pore-to-pore ratio. There are various designs of bone biological scaffolds. Most scaffolds have problems such as irregular micr...
Claims
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IPC IPC(8): A61F2/28
CPCA61F2/28A61F2002/30948A61F2002/30985
Inventor 刘慧通段科科
Owner THE PEOPLES HOSPITAL SHAANXI PROV