A kind of procaterol hydrochloride oral solution

Abstract

The invention relates to a procaterol hydrochloride oral solution. Specifically, the present invention provides a pharmaceutical composition, which comprises Procaterol hydrochloride, flavoring agent, acid-base regulator, phospholipid, complexing agent and solvent. Procaterol hydrochloride oral liquid of the present invention has excellent stability such as thermal stability and photostability, can be simply packed in transparent container and carry out storage and transportation, has reduced production and storage cost, and the patient buys or uses Procaterol hydrochloride When using Procaterol Oral Solution, the properties of Procaterol Hydrochloride Oral Solution, such as clarity, whether there are precipitated particles, mold, rancidity, discoloration, foreign matter, gas production and other deterioration phenomena, can be easily and quickly observed through the transparent container, effectively To ensure the drug safety of Procaterol Hydrochloride Oral Liquid.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a procaterol hydrochloride oral solution. Background technique [0002] Chemical name of procaterol hydrochloride: 5-(1-hydroxy-2-isopropylaminobutyl)-8-hydroxyquinolone hydrochloride hemihydrate, molecular weight: C 16 H 22 N 2 O 3 ·HCI·1 / 2H 2 O, CAS number is 62929-91-3, Procaterol hydrochloride can be used to relieve symptoms such as dyspnea caused by obstructive airway obstruction of the following diseases: bronchial asthma, chronic bronchitis, acute bronchitis, asthmatic bronchitis. [0003] The existing procaterol hydrochloride preparations mainly include tablets, capsules, aerosols and oral liquids. Among various dosage forms, tablets and capsules involve drug dissolution, slow onset of action, inconvenience in taking, and poor compliance with tablets and capsules by patients with difficulty swallowing such as the elderly or children. Although aerosols have...

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Problems solved by technology

[0005] Yet the stability of Procaterol Hydrochloride Oral Liquid is susceptible to the influence of many factors especially as factors such as light and heat, causes content to reduce, and the stability of Procaterol Hydrochloride Oral Liquid is poor, therefore, existing listing Procaterol Hydrochloride In order to improve the stability of Procaterol Hydrochloride Oral Liquid, Procaterol Hydrochloride Oral Liquid is filled in a brown bottle, and it needs to be stored in a shading and 10-30°C environment, thereby increasing the amount of Procaterol Hydrochloride Oral Liquid. The packaging, transportation and storage costs of Luo oral liquid, and because Procaterol hydrochloride oral liquid is packed in brown bottles, it is difficult for patients to understand the properties of Procaterol hydrochloride oral liquid in brown bottles such as clarity, Simple, fast and effective observation of precipitated particles, mold, rancidity, discoloration, foreign matter, gas production and other deterioration phenomena. Therefore, it is difficult to observe the safety of Procaterol Hydrochloride Oral Liquid, which may easily lead to medication safety problems

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