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Organ chip in-situ measurement-oriented multipath signal acquisition control device

A collection control device and organ chip technology, which is applied in measuring devices, program control, computer control, etc., can solve the problems of long-term high-throughput and automatic monitoring of organ chips, so as to improve stability and reliability, save manpower, The effect of increasing the degree of automation

Pending Publication Date: 2021-07-27
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: The purpose of the invention is to provide a multi-channel signal acquisition control device for monitoring the environment in the organ chip and the electrophysiological state of micro-tissues and organs cultured in vitro, and solve the problem of long-term, high-throughput, and automatic monitoring of the organ chip

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  • Organ chip in-situ measurement-oriented multipath signal acquisition control device

Examples

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Embodiment 1

[0010] Example 1: Multi-parameter measurement of multi-chamber parallel chips

[0011] In this embodiment, the organ chip chamber module 1 selects a 12-well cell culture plate, and the signal acquisition unit 2 mounted in each well includes a temperature sensor PT100, a pH sensor, a dissolved oxygen sensor, a sodium ion concentration sensor. The signal amplification and conditioning module 3 consists of a constant current source bridge circuit, an AD620 amplifier circuit, and a 50 Hz notch circuit. MSP430F5529 is used by MSP430F5529.

[0012] The digital signal end of the single chip control module 4 outputs four-bit binary encoding, respectively corresponds to 12 chambers of 12-well cell culture plates, respectively. The cyclic trigger signal is generated by the microcontroller, scanning once every 1 hour, and the signal acquisition time of each chamber is 30 seconds. When the binary coding is consistent with the corresponding chamber, a high level signal is generated to trigger ...

Embodiment 2

[0014] Example 2: Temperature measurement of multi-chamber series chips

[0015] In this embodiment, an organ chip chamber module L selects a 12-well cell culture plate, and the signal acquisition unit 2 mounted in each well includes four temperature resistance modules. The signal amplification and conditioning module 3 is made of a constant current source bridge circuit. MSP430F5529 is used by MSP430F5529.

[0016] The digital signal end of the single chip control module 4 outputs four-bit binary encoding, respectively corresponds to 12 chambers of 12-well cell culture plates, respectively. The cyclic trigger signal is generated by the microcontroller, scans once every 1 minute, and the signal acquisition time of each chamber is 5 seconds. When the binary coding is consistent with the corresponding chamber, a high level signal is generated to trigger a corresponding four sensors.

[0017] The signal amplification and conditioning module 3 can adjust the 4-channel analog voltage s...

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Abstract

The invention discloses an organ chip in-situ measurement-oriented multipath signal acquisition control device, which comprises an organ chip chamber module (1), a signal acquisition unit (2), a signal amplification and conditioning module (3) and a single chip microcomputer control module (4), wherein the modules or units are integrally mounted on the same substrate. The possibility of high-throughput measurement is realized through a time division multiplexing function, and more sensing units can be connected aiming at a limited number of ports of a single-chip microcomputer system. The automation degree of system measurement is improved, and manpower is saved for long-time continuous measurement of the organ chip. The stability and reliability of data acquisition are improved, the possibility of errors caused by manual operation factors is reduced, and system errors caused by manual measurement are avoided.

Description

Technical field [0001] The present invention relates to a chip device, and more particularly to a multi-channel signal acquisition control device for an organ chip in situ measurement. Background technique [0002] ORGAN-ON-A-CHIP is an emerging science technology that conducts cells in vitro in cells in the chip to simulate the function of human organs. The human organ chip can provide a model that is similar to the human environment in the study of the human environment, and provides data for replacement animals and clinical experiments for drug research and development and screening, disease model constructs. However, the current organ chip application is facing a problem that the model characteristics is not uniform, and the acquired data does not have universal applicability, thus limiting its practical application. [0003] In order to obtain the process of the organic chip, the structural and functional information of the microstructure organ itself and the change process ...

Claims

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Application Information

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IPC IPC(8): G01D21/02G05B19/042
CPCG01D21/02G05B19/0423
Inventor 丁海波蔡嘉宁邵栩宁古兰心孙畅
Owner SOUTHEAST UNIV