Nerve restoration promoting tube, preparation method and application thereof

A nerve repair and catheter technology, applied in the field of nerve repair, can solve problems such as deviation of repair process, secondary injury to patients, and materials that are not easy to degrade, and achieve the effect of reducing resistance and reducing damage

Inactive Publication Date: 2021-08-03
戚凤春
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the process of nerve repair, it is necessary to transplant nerve repair tubes to the damaged nerves with large damage gaps, based on the original nerve anatomy and function, to promote the regeneration of damaged or damaged nerves, to repair and reshape, and to rebuild the nerve anatomical projection pathways And the loop, regulation and improvement of nerve signal transmission, and finally the restoration of nerve function. The materials used in the nerve repair tube have the following problem

Method used

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  • Nerve restoration promoting tube, preparation method and application thereof
  • Nerve restoration promoting tube, preparation method and application thereof
  • Nerve restoration promoting tube, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] S1: Single-part layer-by-layer culture: analyze the image information on the detection instrument, and combine 3D printing technology to open grooves with corresponding shapes on the sides of the two culture molds (1) that are close to each other. Coating the chitosan solution with a corresponding thickness inside, and carrying out preliminary cold storage and disinfection treatment on the culture mold (1) attached to the chitosan solution, and making the outer wall of the catheter body (2) of the nerve repair tube;

[0039] S2: On the basis of S1, first coat one or more of glycolic acid solution, polylactic acid solution, hydroxybutyrate solution and hydroxycaproate copolymer solution on the inner wall of the catheter body outer wall (2), Preliminary cold storage and disinfection are carried out again to form a combination of the fiber support layer (3) and the outer wall of the catheter body (2);

[0040] S3: On the basis of S2, one of type I collagen, neurotrophic gr...

Embodiment 2

[0043] Extract autologous tissue:

[0044]M1: Extract the tissue in the patient's body as autologous tissue, such as one of venous blood vessels, degenerated skeletal muscle and stem cells, and sterilize one of the venous blood vessels, degenerated skeletal muscles and stem cells;

[0045] M2: The processed autologous tissue is placed in the position corresponding to the stem cell culture base, denatured skeletal muscle culture base and vein graft culture base, and cultured at low temperature.

[0046] Refrigerated freeze-dried crystals:

[0047] N1: Remove the culture inner core (5) in the two single-part culture molds (1), and apply collagen solution along the section of the outer wall of the catheter body (2), the fiber scaffold layer (3) and the filler layer (4), And fit along the section, and culture at low temperature for a period of time;

[0048] N2: After the cultivation is completed, the overall culture mold (1) is refrigerated and freeze-dried, and the culture mol...

Embodiment 3

[0051] Z1: During the transplant operation, clean and disinfect the injured part;

[0052] Z2: Remove the fresh-keeping nerve repair tube, pre-wet with phosphate buffer solution, and then place the pretreated nerve repair tube in a water bath heating structure containing T-type collagen solution for heating;

[0053] Z3: Place the processed nerve repair tube on the injured nerve, suture the two ends of the nerve repair tube to the damaged nerve, and complete the nerve tube transplantation.

[0054] In summary: during use, chitosan solution is used as the main material of the nerve repair tube, and different materials are filled in the inside of the nerve repair tube to ensure that the nerve repair tube It has a certain mechanical rigidity, which prevents the problem of deformation, and is also conducive to the speed of nerve repair in the later stage.

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Abstract

The invention discloses a nerve restoration promoting tube, a preparation method and the application thereof. The nerve restoration promoting tube comprises a catheter body outer wall, the catheter body outer wall is made of a chitosan solution material, and a fiber support layer, a filler layer, a culture inner core and a biological simulation inner core are sequentially arranged in the catheter body outer wall; the fiber scaffold layer is made of one or more of a polyglycolic acid solution, a polylactic acid solution, a hydroxybutyrate solution and a hydroxyhexanoate copolymer solution, and the filler layer contains type I collagen, neurotrophic growth factors and a growth substrate. The degradable biological material is used as the main material of the nerve restoration tube, the degradable biological material can be automatically degraded into non-toxic and harmless substances after the operation, the injury of a secondary operation to a patient is reduced, the autologous tissue of the patient is used as the substitute nerve tissue, the resistance of the body of the patient to foreign substances is reduced, and nerve restoration and body rehabilitation are facilitated.

Description

technical field [0001] The invention relates to the technical field of nerve repair, in particular to a tube for promoting nerve repair and its preparation method and application. Background technique [0002] Neurorestorative procedure is the abbreviation of neurorestorative surgery. It is an important part of the comprehensive treatment plan of neurorestoration and an important treatment method to enhance the recovery of nervous system function; [0003] In the process of nerve repair, it is necessary to transplant nerve repair tubes to the damaged nerves with large damage gaps, based on the original nerve anatomy and function, to promote the regeneration of damaged or damaged nerves, to repair and reshape, and to rebuild the nerve anatomical projection pathways And the loop, regulation and improvement of nerve signal transmission, and finally the restoration of nerve function. The materials used in the nerve repair tube have the following problems: the material is not eas...

Claims

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Application Information

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IPC IPC(8): A61L27/36A61L27/38A61L27/18A61L27/20A61L27/22A61L27/24A61L27/56A61L27/58A61F2/02
CPCA61F2/02A61F2240/001A61L27/18A61L27/20A61L27/227A61L27/24A61L27/3604A61L27/3625A61L27/3675A61L27/3691A61L27/3834A61L27/3878A61L27/56A61L27/58A61L2430/32C08L5/08
Inventor 戚凤春戚文淏杨佳林崔燕平
Owner 戚凤春
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