Bismuth/barium titanate heterojunction for enhancing sonodynamic tumor resistance and preparation method thereof

A barium titanate and anti-tumor technology, which is applied in the direction of anti-tumor drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of unfriendly environment, uneven coating, complicated process, etc., to achieve enhanced effect and promote Active oxygen generation, enhanced separation effect

Active Publication Date: 2021-08-06
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the nanoscale bismuth element is mainly obtained by electrochemical deposition, and the three-dimensional cathode material is plated with bismuth by electroplating. However, this method is only applicable to three-dimensional materials and is ineffective for loading bismuth element on the surface of nanomaterials. Inhomogeneous and unfriendly to the environment, new methods need to be explored to enable the uniform deposition of bismuth on the surface of nanomaterials

Method used

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  • Bismuth/barium titanate heterojunction for enhancing sonodynamic tumor resistance and preparation method thereof
  • Bismuth/barium titanate heterojunction for enhancing sonodynamic tumor resistance and preparation method thereof
  • Bismuth/barium titanate heterojunction for enhancing sonodynamic tumor resistance and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] 1. Preparation of barium titanate piezoelectric nanoparticles:

[0051] (1) Weigh 25mmol of tetrabutyl titanate and dissolve it in 20mL of absolute ethanol, then slowly add 5mL of ammonia water into the above solution at a rate of 0.5mL / min, and stir for 15min to obtain liquid A.

[0052] (2) Weighing 35mmol of octahydrate barium hydroxide was dissolved in 50mL polytetrafluoroethylene liner with 25mL deionized water, and heated while stirring in a water bath at 90°C until the octahydrate barium hydroxide was completely dissolved to obtain Liquid B.

[0053] (3) Slowly pour liquid A in (1) into liquid B in (2) and stir for 15 minutes. Afterwards, 5 mL of ethanolamine was added dropwise at a rate of 0.5 mL / min, and stirred for 15 min.

[0054] (4) Put the polytetrafluoroethylene lining into a high-temperature and high-pressure reactor, and react at 200° C. for 48 hours. After the reaction, the materials were alternately centrifuged and washed three times with absolute ...

Embodiment 2

[0062] Construction of bismuth / barium titanate heterojunction piezoelectric nanoparticles:

[0063] (1) Weigh 0.2 mmol of bismuth nitrate pentahydrate and dissolve it in 40 mL of deionized water, and stir for 15 min.

[0064] (2) Weigh 0.3 g of the barium titanate nanoparticles synthesized by the hydrothermal method in Example 1 and add them into the solution of (1), and ultrasonically disperse for 15 minutes until the barium titanate nanoparticles are uniformly dispersed.

[0065] (3) Add 1 mmol of sodium borohydride to the solution of (2), and stir the reaction at room temperature for 10 min.

[0066] (4) Immediately after the completion of the reaction, use absolute ethanol and deionized water to alternately centrifuge and wash the material 3 times respectively, wherein the centrifuge speed is 8000 rpm, and the time is 8 minutes, then dry it in an oven at 60 ° C, and sterilize it by ultraviolet light for 60 minutes ,stand-by. Denote the bismuth-supported barium titanate h...

Embodiment 3

[0070] Construction of bismuth / barium titanate heterojunction piezoelectric nanoparticles:

[0071] (1) Weigh 0.2 mmol of bismuth nitrate pentahydrate and dissolve it in 40 mL of deionized water, and stir for 15 min.

[0072] (2) Weigh 0.3 g of the barium titanate nanoparticles synthesized by the hydrothermal method in Example 1 and add them into the solution of (1), and ultrasonically disperse for 15 minutes until the barium titanate nanoparticles are uniformly dispersed.

[0073] (3) Add 2 mmol of sodium borohydride to the solution of (2), and stir the reaction at room temperature for 10 min.

[0074] (4) Immediately after the completion of the reaction, use absolute ethanol and deionized water to alternately centrifuge and wash the material 3 times respectively, wherein the centrifuge speed is 8000 rpm, and the time is 8 minutes, then dry it in an oven at 60 ° C, and sterilize it by ultraviolet light for 60 minutes ,stand-by. Record the bismuth-supported barium titanate h...

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Abstract

The invention discloses a bismuth/barium titanate heterojunction for enhancing sonodynamic tumor resistance and a preparation method thereof. The method comprises the following steps of (1), preparing barium titanate nanoparticles by a hydrothermal method; (2), performing high-temperature and high-pressure polarization treatment on the barium titanate nanoparticles; and (3), depositing bismuth elementary substances on the surfaces of the barium titanate nanoparticles by using a one-step in-situ deposition method to construct the bismuth/barium titanate P-N heterojunction. The bismuth/barium titanate heterojunction has good biocompatibility, high safety and good stability, and the sonodynamic tumor resistance effect can be enhanced.

Description

technical field [0001] The invention belongs to the technical field of tumor nanomaterials for sonodynamic therapy, and in particular relates to a bismuth / barium titanate heterojunction that enhances sonodynamic anti-tumor and a preparation method thereof. Background technique [0002] Breast cancer seriously threatens the life and health of human beings, especially women. The current methods of clinical treatment of breast cancer mainly revolve around surgical resection, chemotherapy and radiotherapy. Surgical removal of the breast is usually the treatment of choice for breast cancer, but incomplete removal can lead to metastasis and recurrence of cancer. Chemotherapy and radiotherapy are often used as auxiliary means to remove tiny lesions, but the side effects will obviously lead to immunocompromised patients or poor therapeutic effect. Sonodynamic therapy (SDT) is a non-invasive, harmless and precise treatment method. The therapy uses ultrasound to activate the sonosen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00
CPCA61K41/0033A61P35/00
Inventor 宁成云杨虹翟锦霞肖才榕于鹏李扬帆周正难张欢
Owner SOUTH CHINA UNIV OF TECH
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