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Phenylboronic acid functionalized Ti3C2Tx magnetic composite material as well as preparation method and application thereof

A magnetic composite material, ti3c2tx-nh2 technology, applied in chemical instruments and methods, separation methods, alkali metal compounds, etc., can solve the sensitivity and selectivity interference of analytical methods, large interference of endogenous compounds, and low abundance of catecholamines and other problems, to achieve the effect of easy surface functionalization, promotion of hydrophobicity and π-π interaction, and simple synthesis method

Active Publication Date: 2021-08-06
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the relatively low content of catecholamines in biological samples and the high interference of endogenous compounds, the sensitivity and selectivity of analytical methods are limited by matrix interference, low abundance of catecholamines, and potential instability

Method used

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  • Phenylboronic acid functionalized Ti3C2Tx magnetic composite material as well as preparation method and application thereof
  • Phenylboronic acid functionalized Ti3C2Tx magnetic composite material as well as preparation method and application thereof
  • Phenylboronic acid functionalized Ti3C2Tx magnetic composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, phenylboronic acid functionalized Ti 3 C 2 T x Preparation of magnetic composites

[0043] A kind of phenylboronic acid functionalized Ti 3 C 2 T x The preparation method of magnetic composite material comprises the following steps:

[0044] (1) Ti 3 C 2 T x -NH 2 Synthesis

[0045] 0.5g Ti 3 C 2 T x Added to a mixture of 80mL ethanol, 5mL water and 7.5mL ammonia water, stirred at room temperature for 24h; then added 2.0mL 3-aminopropyl-3-ethoxysilane (APTES), continued to stir for 24h, centrifuged to collect the product Ti 3 C 2 T x -NH 2 , dried in vacuum at 50°C for 12 hours, and set aside;

[0046] (2) Hyperbranched Ti 3 C 2 T x -CTFs-NH 2 Synthesis

[0047] Take 0.5g Ti 3 C 2 T x -NH 2 , add 50mL THF (tetrahydrofuran) and 1.0g cyanuric chloride, then dropwise add 25mL melamine solution (0.05g / mL), under the condition of nitrogen protection, place it at 0°C for 12h; after the reaction, filter and collect the product Hyperbran...

Embodiment 2

[0056] Embodiment 2, phenylboronic acid functionalized Ti 3 C 2 T x Preparation of magnetic composites

[0057] A kind of phenylboronic acid functionalized Ti 3 C 2 T x The preparation method of magnetic composite material comprises the following steps:

[0058] (1) Add 0.5g Ti 3 C 2 T x Added to a mixture of 75mL ethanol, 4.5mL water and 7mL ammonia water, stirred at room temperature for 22h; then added 1.8mL 3-aminopropyl-3-ethoxysilane (APTES), continued to stir for 22h, centrifuged to collect the product Ti 3 C 2 T x -NH 2 , dried in vacuum at 45°C for 12 hours, and set aside;

[0059] (2) Hyperbranched Ti 3 C 2 T x -CTFs-NH 2 Synthesis

[0060] Take 0.4g Ti 3 C 2 T x -NH 2 , add 45mL THF (tetrahydrofuran) and 0.8g cyanuric chloride, then dropwise add 22mL melamine solution (0.045g / mL), under the condition of nitrogen protection, put it at 0°C for 10h; after the reaction, filter and collect the product Hyperbranched Ti 3 C 2 T x -CTFs-NH 2 , washe...

Embodiment 3

[0065] Embodiment 3, phenylboronic acid functionalized Ti 3 C 2 T x Preparation of magnetic composites

[0066] A kind of phenylboronic acid functionalized Ti 3 C 2 T x The preparation method of magnetic composite material comprises the following steps:

[0067] (1) Add 0.5g Ti 3 C 2 T x Added to a mixture of 85mL ethanol, 5.5mL water and 8mL ammonia water, stirred at room temperature for 23h; then added 2.2mL 3-aminopropyl-3-ethoxysilane (APTES), continued to stir for 23h, centrifuged to collect the product Ti 3 C 2 T x -NH 2 , dried in vacuum at 55°C for 12 hours, and set aside;

[0068] (2) Hyperbranched Ti 3 C 2 T x -CTFs-NH 2 Synthesis

[0069] Take 0.6g Ti 3 C 2 Tx -NH 2 , add 55mL THF (tetrahydrofuran) and 1.2g cyanuric chloride, then dropwise add 27mL melamine solution (0.055g / mL), under the condition of nitrogen protection, put it at 0°C for 11h; after the reaction, filter and collect the product Hyperbranched Ti 3 C 2 T x -CTFs-NH 2 , washed ...

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Abstract

The invention discloses a phenylboronic acid functionalized Ti3C2Tx magnetic composite material and a preparation method and application thereof. The phenylboronic acid functionalized Ti3C2Tx magnetic composite material is prepared by modifying Ti3C2Tx with a multi-layer structure into amino Ti3C2Tx, namely Ti3C2Tx-NH2, then synthesizing Ti3C2Tx-CTFs-NH2 through further hyperbranched reaction of melamine and cyanuric chloride, and carrying out covalent crosslinking on 4-formyl phenylboronic acid through acetal to synthesize boric acid functionalized Ti3C2Tx, namely Ti3C2Tx-BA; and finally dispersing Fe3O4 nano particles in the surface and interlayer structure of Ti3C2Tx-BA to prepare the phenylboronic acid functionalized Ti3C2Tx magnetic composite material, namely Fe3O4@Ti3C2Tx-BA. The phenylboronic acid functionalized Ti3C2Tx magnetic composite material has the advantages of high adsorption capacity, good selectivity, stable structure, simple and convenient synthesis method, low preparation cost, strong regeneration capability, strong anti-interference capability, short extraction time and the like. The preparation method has the advantages of rapidness, high efficiency, low cost, environmental friendliness, reusability and the like.

Description

technical field [0001] The invention relates to a separation material, in particular to a phenylboronic acid functionalized Ti 3 C 2 T x Magnetic composite materials and their preparation methods and applications. Background technique [0002] Catecholamines, including norepinephrine (NE), epinephrine (EP), and dopamine (DA), are neurological substances containing catechol and amine groups, which are involved in various physiological processes in the central and peripheral nervous systems. Plays a vital role in control and regulation. The content changes of catecholamines and their metabolites in the human body have become important indicators in the diagnosis and treatment of Parkinson's disease, Alzheimer's disease, depression and schizophrenia and other diseases. Therefore, the accurate determination of trace catecholamines in biological samples, especially liquid samples, is of great significance to the early diagnosis and treatment of diseases, drug development, bas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30B01D15/00
CPCB01J20/265B01J20/28009B01J20/28054B01D15/00
Inventor 胡锴崔永霞庞田田韩鹏昭赵原庆张振强张书胜
Owner HENAN UNIV OF CHINESE MEDICINE
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