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Chiral covalent organic framework membrane as well as preparation method and application thereof

A covalent organic framework, chirality technology, applied in separation methods, chemical instruments and methods, other chemical processes, etc., can solve the problems of high solubility, instability, lack of pore structure, etc., and achieve low cost and excellent acid resistance. , the effect of simple preparation process

Active Publication Date: 2021-08-06
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional chiral polymer materials are unstable in organic solvents, have high solubility and do not have a pore structure, resulting in the blended membrane prepared by physical modification and the composite membrane (TFC) prepared by chemical modification by interfacial polymerization. Steady structure with an inextricable "tradeoff" between permeate flux and selectivity

Method used

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  • Chiral covalent organic framework membrane as well as preparation method and application thereof
  • Chiral covalent organic framework membrane as well as preparation method and application thereof
  • Chiral covalent organic framework membrane as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] The β-CD COF mixed matrix membrane was first prepared by the following steps, and then the membrane performance was evaluated.

[0048] Synthesis of β-CD COF:

[0049] Hepta(6-amino-6-deoxy)-β-cyclodextrin (20 mmol L -1 ) and terephthalaldehyde (50 mmol L -1 ) was dissolved in a solvent (ethanol-water 50:50 (v / v)), and glacial acetic acid (180 mmol L -1 ) as a catalyst. After ultrasonic mixing, nitrogen gas was flushed for 10 min to remove oxygen in the reaction solution, and the reaction solution was allowed to stand at room temperature for 48 h. After the reaction, the product was collected by centrifugation and washed three times with ethanol and water. Finally, the product was dried in a vacuum oven at 80 °C for 12 h, and the β-CD COF powder was obtained after grinding.

[0050] Preparation of β-CD COF mixed matrix membrane:

[0051] The cellulose acetate was vacuum-dried at 80°C for 6 h to remove moisture. Weigh 0, 5, 10, 15, and 20 mg of β-CDCOF (the conten...

Embodiment 2

[0057] Change the weighed amount of β-CD COF in Example 1 to 0, 15 mg (the content in the entire casting solution is 0.00, 0.75wt%), the amount of DMF added is changed to 1.600, 1.585 g, and the rest are the same as in the example 1.

[0058] The chemical structure and morphology of the β-CD COF mixed matrix membrane prepared in this example were characterized.

[0059] The chemical structures of the cellulose acetate blank base membrane without β-CD COF and the β-CD COF mixed matrix membrane were observed by ATR-FTIR. Such as figure 2 As shown, compared with the cellulose acetate blank base film without β-CD COF, 1641 and 1550 cm -1 Two new peaks are typical characteristic peaks of amide bonds. The chemical structure of β-CD COF contains amide bonds, which indicates that the mixed matrix membrane of β-CD COF was successfully prepared.

[0060] The cellulose acetate blank base film and β-CD COF mixed matrix film were observed by SEM. image 3 The two electron micrographs...

Embodiment 3

[0064] The weighed amount of β-CD COF in Example 1 was changed to 15 mg (the content in the entire casting solution was 0.75 wt%), the amount of DMF added was changed to 1.585 g, and the rest were the same as in Example 1.

[0065] The pH tolerance range of the β-CD COF mixed matrix membrane prepared in this example was evaluated.

[0066] Select 10mM phosphate buffer with pH values ​​of 1, 3, 5, 9, 11, and 13 as the hydrolysis solution, put the prepared β-CD COF mixed matrix membrane into the above buffer, and at the same time, conduct a blank control group, and put The experimental group and the blank group were placed in a constant temperature shaker at 125 r / min for 12 h at the same time. Then, the total organic carbon (TOC) of the experimental group and the blank group were measured respectively, and the hydrolysis of the membrane at different pH values ​​was judged by comparing the TOC values ​​of the experimental group and the blank group, such as Figure 5 It can be s...

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Abstract

The invention discloses a chiral covalent organic framework membrane as well as a preparation method and application thereof, and belongs to the technical field of chiral resolution. The chiral covalent organic framework membrane comprises a cellulose acetate base membrane and a chiral covalent organic framework material, wherein the chiral covalent organic framework material is a beta-cyclodextrin covalent organic framework; and the beta-cyclodextrin covalent organic framework is contained in the cellulose acetate base membrane or adsorbed on the surface of the cellulose acetate base membrane. The preparation process of the chiral covalent organic framework membrane is simple, and the chiral covalent organic framework membrane has the advantages of excellent chiral resolution capability, wide resolution objects, strong acid resistance and potential advantage of industrial application.

Description

technical field [0001] The invention belongs to the technical field of chiral resolution, and in particular relates to a chiral covalent organic framework membrane and its preparation method and application. Background technique [0002] The chiral membrane resolution technique uses specific chiral recognition sites on the membrane to achieve the resolution of racemic mixtures. Membrane separation technology has the advantages of low energy consumption, simple operation, large batch processing capacity, and easy industrial scale-up. It has great potential for industrial application and is one of the most promising candidates for the effective separation of chiral molecules. [0003] According to the membrane morphology, the membrane separation method can be divided into liquid membrane separation method and solid membrane separation method. Liquid films have the advantage of rapid mass transfer, but usually have poor stability and are difficult to apply in industry; solid f...

Claims

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Application Information

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IPC IPC(8): B01J20/29B01J20/30B01D15/38
CPCB01J20/29B01D15/3833
Inventor 季一兵罗欢陈建秋
Owner CHINA PHARM UNIV
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