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A kind of composite nanomaterial, preparation method and application thereof

A technology of composite nanomaterials and solutions, applied in the field of mass spectrometry detection, achieves the effects of good linear relationship, simple operation and good repeatability

Active Publication Date: 2022-03-29
SHANDONG AGRICULTURAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Studies have reported that AuNPs target plate can be used for the detection of metronidazole in liver acetone extract in vitro, and metronidazole can be detected, but there will be many endogenous substance peaks that interfere with mass spectrometry when AuNPs are used alone.

Method used

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  • A kind of composite nanomaterial, preparation method and application thereof
  • A kind of composite nanomaterial, preparation method and application thereof
  • A kind of composite nanomaterial, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] (1) Preparation of composite nanomaterials AuNPs / NiFe-LDHs

[0048] 1) The nano-gold material was synthesized according to the Frens method, and a slight modification was made to adjust the order of adding trisodium citrate (Mw258) and chloroauric acid solutions: first, 50 mL of 4 mM trisodium citrate (Mw 258) aqueous solution was heated to reflux Stir until boiling (about 140°C), add 0.25mL of 200mM chloroauric acid into the boiling solution, heat and reflux for 3min, and obtain (color: light yellow→black purple→wine red) particle size 11-16nm, pH5. 5 gold nanometer solution (AuNPs solution), the obtained AuNPs solution (Au concentration of 1 ± 0.001mM) was diluted 4 times with deionized water.

[0049] 2) Disperse 25mg of NiFe-LDHs in 100mL ethanol solution.

[0050] 3) An equal volume of AuNPs solution was mixed with NiFe-LDH supernatant (1:1, v / v), and sonicated at 200W for 30min at room temperature. After AuNPs and NiFe-LDHs self-assembled completely, they were u...

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Abstract

The invention discloses a composite nanomaterial, a preparation method and its application, and belongs to the technical field of mass spectrometry detection. The composite nanomaterial includes gold colloidal solution and nickel-iron-layered double hydroxide, and the volume ratio of the two is (1 ‑3): (1‑3), the preparation method utilizes the improved Frens method to synthesize nano-gold materials, and NiFe-LDHs and AuNPs self-assemble to form the composite nano-materials for detecting metronidazole and its metabolites, detecting The results have good repeatability and good linear relationship, which can be used for quantification.

Description

technical field [0001] The invention relates to the technical field of mass spectrometry detection, in particular to a composite nanomaterial, a preparation method and an application thereof. Background technique [0002] Metronidazole (MNZ) is a commonly used anti-protozoal infection and anti-anaerobe antibiotics. It has growth-promoting effect and is widely used in clinic and livestock and poultry breeding. However, metronidazole and some metabolites are potentially harmful to humans and animals (may cause typical adverse reactions such as nausea, urticaria, and polyneuropathy). However, illegal or irrational use will cause metronidazole and its antibiotics to enter water, soil, and animal-sourced foods (meat, eggs, milk, honey, etc.) through various routes, and gradually accumulate in the surrounding ecosystem. In addition, metronidazole and its metabolites are difficult to remove due to their nondegradability and high solubility. At present, the detection methods of me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/626
CPCG01N27/628
Inventor 马春霞郑振佳李玲玉王明林徐龙华
Owner SHANDONG AGRICULTURAL UNIVERSITY
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