Integrated program-controlled closed-loop optogenetics system

Abstract

The invention discloses an integrated program-controlled closed-loop optogenetics system which comprises an integrated program-controlled closed-loop laser generator and an optical fiber probe, wherein the integrated program-controlled closed-loop laser generator comprises a core control board, a laser, as well as an external trigger port, a power supply module, a touch display module, a laser driving module and an optical power meter which are connected with the core control board. Integrated design is adopted for the laser generator, the whole system is small in structure, complete in function, convenient to carry and capable of being conveniently applied to optogenetics animal experiments, all modules in the integrated program-controlled closed-loop laser generator are integrally designed, the system is slightly influenced by the outside, and electromagnetic compatibility is greatly improved; in combination with the optical power meter, closed-loop control of the light intensity of the laser can be realized, and optical signals output by the laser can be ensured to be stable and reliable; and by arranging the touch display module and the external trigger port, multi-trigger-mode program control input can be achieved, and system functions can be expanded conveniently.

Description

technical field [0001] The invention relates to the fields of optogenetics and medical equipment, in particular to an integrated program-controlled closed-loop optogenetics system. Background technique [0002] Optogenetics technology is a new multidisciplinary interdisciplinary animal technology that precisely controls cell activity by combining optical technology, genetic technology and electronic information engineering technology. Using optogenetics technology, neuroscience researchers can deeply explore the position and relationship between neurons in a nucleus, and understand the internal interaction between multiple nuclei, so as to have a profound impact on the structure and function of the brain and nervous system. A clearer understanding, as the technology is increasingly used in research fields such as neuroscience, cellular zoology, signaling pathways, and more. In addition to basic neuron structure research, using optogenetic technology and some animal disease ...

AI Technical Summary

Problems solved by technology

After several years of development, optogenetics has developed rapidly. However, the research and development and production of optogenetics devices are still in a relatively simple initial stage.

[0004] Currently patented and common optogenetic devices on the market mostly use a simple signal generator connected to a laser driver to drive the laser to emit laser light and transmit it through optical fibers. Since each module is connected by a cable, the system is large in scale and not easy to carry. At the same time, the system adopts split type Modular design is susceptible to external interference and low electromagnetic compatibility. In use, especially when working with other equipment, it is easy to cause optical signal instability and affect the experimental results; on the other hand, the existing optogenetic system has a single structure and function. Program control of light stimulation, external trigger control and multi-device collaboration cannot be realized

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