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Low-swelling Janus conductive hydrogel as well as preparation method and application thereof

A conductive hydrogel and hydrogel technology, applied in the field of materials, can solve problems such as secondary trauma to biological tissues, and achieve the effects of low swelling rate, low cost and good mechanical properties

Active Publication Date: 2021-08-17
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recently, LiuWenguang et al. reported a double-faced hydrogel adhesive for internal tissue repair, which has strong adhesion to wet biological tissue on the one hand and no adhesiveness on the other; Adhesives have significant advantages over traditional sutures and traditional double-sided bioadhesives: on the one hand, traditional sutures can easily cause secondary trauma to biological tissues; pain; traditional bioadhesives not only have an adhesive effect on the wound, but also have an adhesive effect on the surrounding tissue. After use, it is easy to adhere to the external surrounding tissue. Postoperative inflammation, intestinal obstruction and other serious adverse consequences caused by postoperative adhesion , often requires secondary surgery, but Janus Hydrogel does not have the above problems
[0004] Janus hydrogels are very important in a variety of applications, but the research on Janus hydrogels is still in its preliminary stage, so far there are few reports on Janus hydrogels with conductive-dielectric properties

Method used

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  • Low-swelling Janus conductive hydrogel as well as preparation method and application thereof
  • Low-swelling Janus conductive hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] A preparation method of low swelling "Janus" conductive hydrogel, which comprises the following steps:

[0023] (1) Put polyvinyl alcohol and tannic acid in water, stir at a constant temperature of 90°C for 30-60 minutes to obtain a polyvinyl alcohol-tannic acid mixed solution, and cool to room temperature;

[0024] (2) Put sodium alginate in the same amount of water as in step (1), and stir at room temperature for 60-120 min to obtain an aqueous solution of sodium alginate.

[0025] (3) Add the polyvinyl alcohol-tannic acid mixed solution obtained in step (1) to the sodium alginate aqueous solution obtained in step (2), stir and mix evenly to obtain a polyvinyl alcohol-tannic acid-sodium alginate mixed solution solution;

[0026] (4) After centrifuging the mixed solution obtained in step (3), transfer it to a mold, and let it stand for stratification.

[0027] (5) Freeze the solution after standing and stratifying in the refrigerator, and then take it out and melt it...

Embodiment 1

[0043] Add a mixture of 1.5925g polyvinyl alcohol and 0.1800g tannic acid into 19.0000g deionized water, raise the temperature to 90°C, stir for 1h, then cool the mixture to room temperature to obtain a tannic acid-polyvinyl alcohol mixed solution. Add 0.2275g of sodium alginate to 19.0000g of deionized water at room temperature, stir for 2 hours until dissolved, and obtain a sodium alginate solution.

[0044]Add the tannic acid-polyvinyl alcohol mixed solution into the sodium alginate solution, and stir for 30 minutes to make it evenly mixed. The mixed solution was centrifuged and transferred to a mold, and left to stand at room temperature for 1 h. The solution after static stratification was frozen in the refrigerator for 8 hours, taken out and thawed for 2 hours, and the operation was repeated 3 times. Soak the upper layer of the obtained hydrogel in 1% calcium chloride solution for 60 minutes to obtain a low-swelling "Janus" conductive hydrogel.

Embodiment 2

[0046] Repeat Example 1, the difference is: the mass concentration of calcium chloride solution is 2%.

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Abstract

The invention belongs to the field of materials, and relates to low-swelling Janus conductive hydrogel and a preparation method and application thereof, and the preparation method comprises the following steps: preparing a polyvinyl alcohol-tannic acid mixed solution; uniformly mixing the polyvinyl alcohol-tannic acid mixed solution with the sodium alginate solution to obtain a polyvinyl alcohol-tannic acid-sodium alginate mixed solution; centrifuging the polyvinyl alcohol-tannic acid-sodium alginate mixed solution, standing for layering, and performing freezing-melting circulation for multiple times to obtain hydrogel; and soaking the upper layer of the hydrogel in a calcium chloride solution to obtain the low-swelling Janus conductive hydrogel. The Janus conductive hydrogel prepared by the invention not only has excellent swelling resistance and mechanical properties, but also has remarkably different conductive properties (one side is strongly conductive and the other side is weakly conductive) on two sides, and has a wide application prospect in bioelectronics (such as artificial skin, biosensors, intelligent robots and the like).

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a preparation method of a low-swelling "Janus" conductive hydrogel. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Hydrogel is a swelling system formed after the hydrophilic three-dimensional polymer network absorbs water, and the water content in it is often ten times or even dozens of times that of the hydrophilic polymer. Hydrogels have squishy properties similar to biological tissues or organs, and have been widely used or shown good application prospects in many fields, especially biomedical fields, and have attracted extensive attention from researchers. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J7/12C08L29/04C08L97/00C08L5/04
CPCC08J3/075C08J7/12C08J2329/04C08J2497/00C08J2405/04
Inventor 邢雅成马晓梅战艺伟
Owner QINGDAO UNIV