Aryl thiazole-tryptamine compound for killing skeletonema costatum and combination agent thereof

A technology of algae killing combination agent and arylthiazole, which is applied in biocides, herbicides, algicides, biocides, etc., can solve the problems of precipitation and precipitation, achieve high biocompatibility and reduce usage , good compatibility effect

Pending Publication Date: 2021-08-24
YANTAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the process of in-depth development, we found that: aryl-tryptamine algicidal active substances only have good solubility in dimethyl sulfoxide, and under high concentration and long-term storage conditions, some of them are separated out and precipitated. question

Method used

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  • Aryl thiazole-tryptamine compound for killing skeletonema costatum and combination agent thereof
  • Aryl thiazole-tryptamine compound for killing skeletonema costatum and combination agent thereof
  • Aryl thiazole-tryptamine compound for killing skeletonema costatum and combination agent thereof

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Embodiment Construction

[0035] Below in conjunction with embodiment, experimental data and accompanying drawing further illustrate the present invention.

[0036] 1. Synthesis of 4-ethoxybenzothiazole-5-methoxytryptamine (5).

[0037]

[0038] Dissolve 10mmol of 5-methoxytryptamine 4 in 50ml of dry dichloromethane, add 12mmol of trimethylaluminum n-hexane solution dropwise to the reaction system under ice-water conditions, bubbles are generated, and then the solution Gradually become clear, after heating up to normal temperature for 0.5 hours, 100ml of methylene chloride solution dissolved with 10mmol 4-ethoxybenzothiazole methyl ester 3 was added dropwise to the reaction system, stirred for 5 hours, then quenched with 1N hydrochloric acid solution reaction, adding water and dichloromethane, and extracting three times, the organic phases were combined, dried over anhydrous sodium sulfate, filtered, and spin-dried, and separated by column chromatography to obtain 4-ethoxybenzothiazole-5-methoxytryp...

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Abstract

The invention discloses an aryl thiazole-tryptamine compound for killing skeletonema costatum and a combination agent thereof. The combination agent for killing the skeletonema costatum is composed of aryl thiazole-tryptamine, isothiazolinone, an auxiliary ingredient and a solvent. The combination agent has the advantages of being simple in synthesis/preparation, remarkable in effect, lasting in drug effect, high in biological safety and the like, growth of skeletonema costatum can be inhibited for a long time while the biological safety is guaranteed, and after 10 days, growth of skeletonema costatum still does not rebound. The compound and the combination agent thereof are suitable for industrial production and popularization.

Description

technical field [0001] The invention relates to an algicidal compound for Sclerostetes mesosicae and an algicidal combination containing the compound and belongs to the technical field of mariculture and utilization of marine biological resources. Background technique [0002] The large-scale outbreak of marine algal blooms directly affects the stability of the marine ecosystem and the healthy development of marine industries such as aquaculture. Skeletonema costatum is the diatom red tide species that has the greatest impact on my country's coastal waters. In recent years, it has been found that it is not only the chief culprit that caused multiple red tides in the Yangtze River Estuary, but also can be combined with kelp and laver in economical seaweed breeding areas. Competing for nutrients, causing discoloration, decay, and even death of a large number of economical algae. Studies have shown that the overgrowth of Skeletons costata can deeply damage the gills of Atlantic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D417/12A01N43/78A01P13/00
CPCC07D417/12A01N43/78
Inventor 刘义李昱静王晓玲刘建国刘慧丽侯晓君李荣萍
Owner YANTAI UNIV
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