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Composition for skin beautifying and anti-aging, and preparation method thereof

A composition and anti-aging technology, applied in skin care preparations, toiletry preparations, medical preparations containing active ingredients, etc., can solve the problems of sepsis, bFGF with large molecular weight, difficult skin absorption, etc., to improve beauty Anti-aging effect, efficiency-promoting effect

Pending Publication Date: 2021-08-27
四川省恩乐生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

FGF is further divided into aFGF (acidic) and bFGF (alkaline), and bFGF is currently used more, but bFGF has certain limitations in current application: (1) bFGF has a large molecular weight and is difficult to be absorbed by the skin. Therefore, the products widely appearing on the market are to prepare bFGF into some gel preparations, liquid preparations, etc. for wound repair on the wound surface; although there are also patent reports that it can be used in cosmetics, the relevant reports are not Many, and there is no corresponding product on the market
(2) Although Japan uses bFGF for skin beauty and anti-aging, the method of use is subcutaneous injection, which will cause wounds to the human body, and has high requirements for product sterility. Cause skin infection, inflammation, and even sepsis, etc., the risk of use is higher

Method used

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  • Composition for skin beautifying and anti-aging, and preparation method thereof
  • Composition for skin beautifying and anti-aging, and preparation method thereof
  • Composition for skin beautifying and anti-aging, and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] A cosmetic raw material with beauty and anti-aging effects, independently developed and prepared by Sichuan Enle Bioengineering Co., Ltd., can be well applied in cosmetic formulas to achieve skin beauty and anti-aging. The raw material composition is named "TAT-EL young peptide".

[0029] The formulation of "TAT-EL young peptide" is as follows in Table 1:

[0030] Table 1

[0031] Raw material name Amount added (parts by weight) supplier information bFGF 10 Shanghai Puxin TAT small molecule penetrating peptide 10 Wuhan Baiyixin Biology Mannitol 3 collagen 3 Sodium chloride 0.025 Disodium phosphate 0.003 Sodium dihydrogen phosphate 0.004 water 73.968

[0032] The preparation process of the "TAT-EL young peptide" is as follows:

[0033] (1) According to the corresponding weight ratio, the raw materials are mixed;

[0034] (2) Pre-freezing: put the mixture obtained in step (1) into a freez...

experiment example 1

[0059] The efficacy of the youth peptide products obtained in Example 1 and Comparative Examples 1-2 was investigated, and the aqueous solution containing "TAT-EL youth peptide (Example 1)" was used to smear around the eyes of the human body with a concentration of 2%, and the use cycle: 7 Days, frequency of use: apply once a day in the morning and evening, amount of application: 0.5-1ml each time, investigate its beauty and anti-aging effects on the skin, the results are as follows figure 1 and 2 shown.

[0060] From figure 1 and figure 2 It can be seen that the "TAT-EL youthful peptide" product obtained in Example 1 of the present invention can well remove wrinkles at the corners of the eyes and have a good beauty and anti-aging effect.

[0061] And adopt the young peptide product obtained in comparative example 1-2 to carry out the above experiment, although it can also have a certain effect of removing wrinkles at the corner of the eye, its beauty and anti-aging effect...

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Abstract

The invention provides a composition for skin beautifying and anti-aging. The composition is prepared from, by weight, 10 parts of fibroblast growth factors, 10 parts of TAT small molecule cell-penetrating peptides, 3 parts of mannitol, 3 parts of collagen, 0.025 part of sodium chloride, 0.003 part of disodium hydrogen phosphate, 0.004 part of sodium dihydrogen phosphate and 73.968 parts of water. The invention also provides a preparation method of the composition. The composition provided by the invention can promote the bFGF to be better absorbed by the skin and exert the effect, can be well used for beautifying and anti-aging of the skin, and is extremely remarkable in effect, mild in use condition and suitable for large-scale popularization and use.

Description

technical field [0001] The invention belongs to the technical field of beauty and makeup products, and in particular relates to a composition for skin beauty and anti-aging and a preparation method thereof. Background technique [0002] As we all know, the skin is the largest organ of the human body. It is reported that the total weight of the human skin accounts for 5% to 15% of the body weight, and the total area of ​​the skin can reach 1.5 to 2 square meters. The role of skin in medicine is very important to the human body. The skin has the function of maintaining the stability of the internal environment of the human body, preventing the loss of water, electrolytes and other nutrients in the body, and acting as a barrier to prevent the invasion of harmful substances from the outside. It plays a physiological role. Skin has an important protective function, and at the same time, the skin is also an important sign and symbol of human health and aging, and has an important ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/65A61K8/02A61K8/20A61K8/24A61K8/34A61Q19/08A61Q19/00
CPCA61K8/64A61K8/345A61K8/65A61K8/20A61K8/24A61K8/022A61Q19/08A61Q19/00A61K2800/84
Inventor 杨丹宋筱荭邹弼臣
Owner 四川省恩乐生物工程有限公司