Method and device for imaging three-dimensional blood flow in cavity based on MEMS micro galvanometer
An imaging method and miniature technology, applied in the field of biomedical imaging, can solve problems such as image shaking, achieve the effects of eliminating image distortion, improving signal-to-noise ratio and contrast, and accurate extraction
Active Publication Date: 2021-09-03
ZHEJIANG UNIV
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[0005] In addition, tissue movement due to breathing, heartbeat and other reasons cannot be avoided during endoscopic imaging, and the high-speed scanning of the endoscopic probe will also cause image jitter, However, OCTA angiography requires more stable multi-frame repetition at the same position.
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[0067] Specific embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings, which form a part of this document. It should be noted that these descriptions and examples are illustrative only, and should not be construed as limiting the scope of the present invention. The protection scope of the present invention is defined by the appended claims, and any changes based on the claims of the present invention All are protection scope of the present invention.
[0068] In order to facilitate the understanding of the embodiments of the present invention, each operation is described as a plurality of discrete operations, however, the order of description does not represent the order in which the operations are performed.
[0069] This description uses the three-dimensional spatial direction x-y-z coordinates to represent the sample measurement space. This description is provided merely to facilitate discussion and is not inte...
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The invention discloses a method and a device for imaging three-dimensional blood flow in a cavity based on an MEMS micro galvanometer. The method comprises the following steps: carrying out optical coherence detection, enabling an MEMS micro galvanometer scanning probe to enter a cavity, carrying out repeated scanning on tissues in the cavity, detecting scattered signals of a three-dimensional space of the tissues in the cavity, and reconstructing the scattered signals to obtain a structural image; if the structural image has nonlinear distortion, performing cross-correlation operation on adjacent rows of the scattering signal to estimate the scanning speed, and performing data resampling on the distorted structural image according to cross-correlation coefficient distribution to realize nonlinear region distortion correction; correcting tissue motion and image dithering; performing blood flow imaging, and optical coherence blood flow radiography of motion contrast by utilizing time dynamic characteristics of scattered signals. According to the method, high-sensitivity extraction of blood flow distribution information in the narrow and long cavity of the human body can be realized, and the signal-to-noise ratio and contrast ratio of the blood flow contrast image are effectively improved.
Description
technical field [0001] The present invention relates generally to the field of biomedical imaging, and more particularly to methods associated with Endoscopic Optical Coherence Tomography (Endo-OCT) and Endoscopic OCT Angiography (Endo-OCTA) , a device and a system, which can be used to acquire three-dimensional blood flow signals in a cavity. Background technique [0002] Traditional imaging examinations such as CT, MRI, and ultrasound can show structural changes in the overall lumen, but cannot perform vascular imaging, making it difficult to accurately evaluate the lesion. The recent emergence of narrow-band light imaging and confocal microscopy can realize the imaging of mucosal blood vessels. However, the resolution of narrow-band optical imaging is limited, and only the surface blood vessels can be seen, and deep blood vessel detection cannot be performed. However, confocal microscopy has a small field of view (<0.4mm×0.4 mm), and requires additional injection of ...
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Login to View More IPC IPC(8): A61B5/026A61B5/00
CPCA61B5/0261A61B5/0084
Inventor 李鹏姚霖
Owner ZHEJIANG UNIV