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Preparation method of pentoxifylline powder for injection

A technology of pentoxifylline and theobromine powder, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, powder transportation, etc. Preservation and other issues, to achieve the effect of improving quality, complete and pure crystallization, and strengthening stability

Inactive Publication Date: 2021-09-03
HAINAN GENERAL & KANGLI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The embodiment of the present application provides a preparation method of pentoxifylline powder for injection, which is used to solve the existing technical problems that pentoxifylline is not easy to store, and impurities are easily produced under high temperature or exposure to light, thereby affecting the curative effect

Method used

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  • Preparation method of pentoxifylline powder for injection
  • Preparation method of pentoxifylline powder for injection
  • Preparation method of pentoxifylline powder for injection

Examples

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Embodiment 1

[0032] For ease of understanding, see figure 1 , an embodiment of the preparation method of the pentoxifylline powder for injection provided by the application comprises the following steps:

[0033] Step 1, material preparation: prepare pentoxifylline, verapamil hydrochloride, mannitol and water for injection according to the prescription;

[0034] Step 2. Concentrated preparation: add 30% water for injection in the concentrated preparation tank, add appropriate amount of verapamil hydrochloride and mannitol in turn, stir evenly, finally add appropriate amount of pentoxifylline, and stir until Dissolve completely, get concentrated solution;

[0035] Step 3. Dilute formulation: add 70% of the configured water for injection into the dilute formulation tank, transfer the liquid medicine in the concentrated formulation tank to the dilute formulation tank, add medicinal activated carbon, stir evenly, add a pH regulator to adjust the pH value To 5.3~5.7, filter to remove charcoal...

Embodiment 2

[0044] Preparation method of pentoxifylline powder injection for injection

[0045] prescription:

[0046] 10 parts by weight of pentoxifylline

[0047] 2 parts by weight of verapamil hydrochloride

[0048] 10 parts by weight mannitol

[0049] 200 parts by weight of water for injection

[0050] Preparation Process:

[0051] Add 60 parts by weight of water for injection into the concentrated preparation tank, then add 10 parts by weight of pentoxifylline, 2 parts by weight of verapamil hydrochloride and 10 parts by weight of mannitol, and stir evenly to obtain a concentrated solution; Add 140 parts by weight of water for injection into the tank, keep the temperature of the water for injection at 75°C, transfer the concentrated solution to the dilute tank, add medicinal activated carbon to stir, add fumaric acid to adjust the pH value to 5.5, filter to remove charcoal to obtain the carbon-removing filtrate; use 0.45 μm and 0.22 μm microporous membranes in turn to carry out ...

Embodiment 3

[0053] Preparation method of pentoxifylline powder injection for injection

[0054] prescription:

[0055] 12 parts by weight of pentoxifylline

[0056] 2 parts by weight of verapamil hydrochloride

[0057] 15 parts by weight mannitol

[0058] 300 parts by weight of water for injection

[0059] Preparation Process:

[0060] Add 70 parts by weight of water for injection in the concentrated preparation tank, then add 12 parts by weight of pentoxifylline, 2 parts by weight of verapamil hydrochloride and 15 parts by weight of mannitol, and stir evenly to obtain a concentrated solution; Add 230 parts by weight of water for injection into the tank, keep the temperature of the water for injection at 85°C, transfer the concentrated solution to the dilute tank, add medicinal activated carbon for stirring, add fumaric acid to adjust the pH value to 5.7, filter to remove charcoal to obtain the carbon-removing filtrate; use 0.45 μm and 0.22 μm microporous membranes in turn to carry o...

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Abstract

The invention discloses a preparation method of pentoxifylline powder for injection. The preparation method comprises nine steps of material preparation, concentrating, dilution, fine filtration and sterilization, preparation of penicillin bottles, preparation of rubber stoppers, crystallization, preparation of sterile powder and subpackaging. The preparation procedures are simple and easy in operations. Pentoxifylline, verapamil hydrochloride, mannitol and water for injection are sequentially concentrated and diluted in formula dosage, thereby ensuring thorough mixing of pentoxifylline, verapamil hydrochloride, mannitol and water for injection, and enhancing stability of the medicine. The invention provides the preparation method of the pentoxifylline powder for injection, and solves the technical problems of difficult preservation and easy generation of impurities at high temperature or under the light for existing pentoxifylline, thereby affecting curative effect.

Description

technical field [0001] The application relates to the technical field of medicine preparation, in particular to a preparation method of pentoxifylline powder for injection. Background technique [0002] Pentoxifylline is a methylxanthine derivative. It is an alkaloid obtained from theobromine extracted from cocoa beans and then introduced into a pentanone group. It is a white powder or granule; it has a slight odor and a slight bitterness; Soluble in triazine, soluble in water or ethanol, slightly soluble in ether. The molecular formula is C13H18N4O3, and the chemical name is 3,7-dihydro-3,7-dimethyl-1-(5-oxohexyl). It can improve blood circulation in the brain and extremities, increase blood flow in arteries and capillaries, and reduce peripheral vascular resistance, but has no effect on blood pressure. It can also improve the rheological properties of blood by improving the deformability of blood cells damaged by pathology, inhibit platelet aggregation, reduce blood visc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/522A61K47/26A61P1/16A61P7/02A61P9/12A61P11/08A61K9/14A61K31/047A61K31/277
CPCA61K31/277A61K31/522A61K31/047A61K9/14A61K9/0019A61K47/26A61P9/12A61P1/16A61P7/02A61P11/08A61K2300/00
Inventor 彭先芬符永红肖汉文林方育唐雄肇
Owner HAINAN GENERAL & KANGLI PHARMA
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