Application of mogroside V and biomarker of mogroside V acting on lung inflammation

Abstract

The invention discloses new application of mogroside V and a biomarkers of the mogroside V acting on lung inflammation. The first application: the mogroside V is used for preparing medicine for treating the lung inflammation. The second application: the mogroside V serves as an inhibitor and is used for improving and reducing the increase of the content of TNF-alpha, IL-4 and IgE inflammatory factors and the reduction of the content of IFN-gamma caused by OVA stimulation, and inflammatory infiltration in lung tissue is relieved. The third application: the mogroside V is used for preparing the medicine for relieving cough or relieving cough and moistening lung. The invention also researches a biomarker of mogroside V acting on lung inflammation, wherein the biomarker is taurine, hypotaurine, pyridoxine, 5-phosphopyridoxal, histidine and aspartic acid. The invention provides new application of the mogroside V. The mogroside V has the effects of eliminating lung inflammation and moistening the lung to arrest cough, is low in toxic and side effects, can be used for development of clinical cough and lung moistening medicines, and is wide in market prospect.

Description

technical field [0001] The present invention relates to mogroside V, specifically the new application of mogroside V and its biomarker acting on lung inflammation. Background technique [0002] Luo Han Guo is a characteristic "dual-use food and medicine" drug in my country, which has high edible value and medicinal value. Phytochemical research results show that there are more than 20 kinds of cucurbitane triterpenoids and several flavonoids in Luo Han Guo. According to reports, the main substance in Luo Han Guo is mogroside compounds, and the ingredient that has the effect of "relieving cough and moisturizing the lungs" is mogroside V, and its content can reach 52% of the total saponins. Mogroside can reduce the pulmonary inflammatory response caused by OVA by down-regulating Th2 cell-specific immune response, reducing various interleukins (ILs), tumor necrosis factor (TNF-α), γ-interferon (IFN-γ) and other factors, It can also treat acute lung injury caused by LPS by reg...

AI Technical Summary

Problems solved by technology

The active components of natural Chinese herbal medicine are complex, with the characteristics of multi-target and comprehensive regulation. This is not only the advantage of traditional Chinese medicine in treating diseases, but it also limits the research and development of Chinese herbal medicine. It still only stays at the level of Luo Han Guo phenotype, and rarely goes deep into the specific mechanism

Although the efficacy of "Moisturizing the lungs and relieving cough" of Luo Han Guo is widely known, there is still a lack of systematic theoretical basis to support it. It is urgent to use experimental methods to explain the mechanism of action of Luo Han Guo "moistening the lungs and relieving cough"

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