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A kind of preparation method and product of hemostatic material

The technology of hemostatic material and absorbent cotton is applied in the field of materials, which can solve the problems of reducing the rapid hemostasis performance of inorganic materials and not being suitable for pre-hospital first aid.

Active Publication Date: 2022-07-29
INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Mesoporous silicon has good hemostatic properties and room for functional upgrades, but hemostatic materials in the form of powder or granules are not suitable for pre-hospital first aid, and there are hidden dangers of residues
General material compounding methods, such as wrapping with polymer materials, coating on non-woven fabrics, spinning mixed liquid, etc., often cannot solve the residual problem, and sometimes reduce the rapid hemostatic performance of inorganic materials
[0005] How to obtain mesoporous silicon through a milder process, and effectively fix and compound it with the most widely used absorbent cotton, and at the same time achieve rapid hemostasis, safety (not suitable for residual) and easy operation of pre-hospital first aid, there are still large technical barriers

Method used

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  • A kind of preparation method and product of hemostatic material
  • A kind of preparation method and product of hemostatic material
  • A kind of preparation method and product of hemostatic material

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preparation example Construction

[0046] The embodiment of the present invention relates to a preparation method of a hemostatic material, which at least includes the following steps:

[0047] S1. Pre-treatment of absorbent cotton;

[0048] S2. Dissolve the template agent P123 and absolute ethanol in acetic acid-sodium acetate buffer solution, add sodium orthosilicate and ethyl orthosilicate in sequence, and continue to stir at 35 to 45 ° C for 12 to 36 hours to form a mesoporous silicon precursor gel;

[0049] S3. Place the pretreated absorbent cotton in the mesoporous silicon precursor gel, react and age at 95-100°C for 20-30 hours;

[0050]S4. The reacted absorbent cotton is filtered, dried, washed and dried to obtain a mesoporous silicon-absorbent cotton in-situ composite hemostatic material (may be referred to as: mesoporous silicon-absorbent cotton composite material). Meanwhile, the inorganic powder in the reaction solution is centrifuged, filtered, dried, washed and dried to obtain mesoporous silicon...

Embodiment 1

[0065] A mesoporous silicon-absorbent cotton in-situ composite hemostatic material, the preparation method comprising the following steps:

[0066] Step 1: Put the medical absorbent cotton in acetone for ultrasonic treatment for 10min and then dry it for later use;

[0067] Step 2: 1.16 g of P123 and 2 mL of absolute ethanol were dissolved in 30 mL of acetic acid-sodium acetate buffer solution (pH 4.4) under stirring at 25°C at 1000 rpm. After adding sodium orthosilicate (1.84g, 0.01 mole) to the above solution and stirring for 10 minutes, then adding ethyl orthosilicate (2.08g, 0.01 mole), the molar ratio of ethyl orthosilicate in the silicon source is 50 %, heated to 40 °C, and continued to stir for 20 h to form a mesoporous silicon precursor gel;

[0068] Step 3: The pretreated absorbent cotton is placed in the mesoporous silicon precursor gel, and then the whole is transferred to a hydrothermal reaction kettle lined with tetrafluoroethylene, and the whole reaction is aged...

Embodiment 2

[0074] A mesoporous silicon-absorbent cotton in-situ composite hemostatic material, the preparation method comprising the following steps:

[0075] Step 1: put the medical absorbent cotton in acetone for ultrasonic treatment for 20min and then dry it for later use;

[0076] Step 2: 1.16 g of P123 and 2.5 mL of absolute ethanol were dissolved in 30 mL of acetic acid-sodium acetate buffer solution (pH 4.4) under stirring at 25°C at 1200 rpm. Add sodium orthosilicate (0.014 mol) to the above solution and stir for 10 minutes, then add ethyl orthosilicate (0.006 mol), the molar ratio of ethyl orthosilicate in the silicon source is 30%, and the temperature is raised to 40 ° C , continue to stir for 24h to form mesoporous silicon precursor gel;

[0077] Step 3: put the pretreated absorbent cotton in the mesoporous silicon precursor gel, and then transfer the whole to a hydrothermal reactor lined with tetrafluoroethylene, and react and age at 100°C for 24 hours;

[0078] Step 4: fil...

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Abstract

The invention relates to the field of materials, in particular, to a preparation method and product of a hemostatic material. The preparation method of the hemostatic material of the present invention includes the following steps: pre-treating absorbent cotton; dissolving and dispersing the template agent P123 and absolute ethanol in acetic acid-sodium acetate buffer solution, adding sodium orthosilicate and ethyl orthosilicate in sequence; continuing to stir Mesoporous silicon precursor gel is formed; the pre-treated absorbent cotton is placed in the mesoporous silicon precursor gel, and the overall reaction is aging; and then filtered, dried, washed, and dried to obtain mesoporous silicon-absorbent cotton In situ composite hemostatic material. The hemostatic material prepared by the invention can simultaneously realize rapid hemostasis, safety and easy operation of pre-hospital first aid.

Description

technical field [0001] The invention relates to the field of materials, in particular, to a preparation method and product of a hemostatic material. Background technique [0002] Uncontrollable hemorrhage is an important cause of casualties in modern warfare, as well as an important cause of death of patients with accidental trauma in peacetime. Whether the bleeding of the wounded can be treated quickly and effectively, and the timely pre-hospital hemostasis, will directly affect the infection rate and mortality rate. Since the prime time for emergency care is only 10 minutes, the application of pre-hospital rapid hemostatic materials is particularly important. The ideal hemostatic material for on-site first aid should have the following characteristics: ① It can be used directly on the bleeding wound and can control the bleeding of large arteries and veins within 2 minutes; ② It does not require mixing or other preparations before use; ③ It is easy to use, even for non-med...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/02A61L24/00
CPCA61L24/0047A61L24/02A61L24/0036A61L24/0005A61L2400/04
Inventor 李钒张卓然杨焜丁晟田丰林松
Owner INST OF MEDICAL SUPPORT TECH OF ACAD OF SYST ENG OF ACAD OF MILITARY SCI
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