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Mangiferin and preparation method thereof

A technology for mangiferin and raw materials, which is applied to the field of mangiferin and its preparation, can solve the problems of poor extraction effect, complicated general process, low yield of mangiferin, etc., and achieves simple and easy operation of the preparation method, reduction of production cost, and realization of industrialization. production effect

Active Publication Date: 2021-09-21
西安金泰生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are many existing methods for isolating MGF from mango leaves, including ultrasonic extraction, microwave-assisted extraction, decoction, ester extraction and impurity removal, etc., the general process is relatively complicated, and the extraction effect is not good. Low glycoside yield

Method used

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preparation example Construction

[0025] The invention provides a kind of preparation method of mangiferin, comprising the steps of:

[0026] The raw material is treated with activated carbon and extracted to obtain mangiferin;

[0027] The raw material is mango leaves and / or almond leaves; the extraction is anhydrous methanol extraction, and the extraction temperature is 60-65°C.

[0028] In the present invention, the raw material is mango leaf and / or almond leaf, and the mass ratio of the raw material to activated carbon is preferably 5:1 to 30:1, more preferably 10:1. In the present invention, the raw material is preferably pulverized to 10-100 mesh, more preferably 20 mesh, and then mixed with activated carbon. Activated carbon of the present invention is preferably powdery activated carbon. In the present invention, activated carbon is irreplaceable and has the functions of decolorization and impurity removal. Using activated carbon to treat mango leaves or almond leaves can remove the chlorophyll of th...

Embodiment 1

[0041] 1) Take 100kg of crushed mango leaves (about 3% mangiferin content), crush them to less than 20 meshes, put them into an extraction tank, add 10kg of activated carbon powder, and extract twice with anhydrous methanol under reflux, each time for 4 hours, and the extraction temperature is 65°C. The extraction pressure is normal pressure, add 800L methanol for the first extraction, and add 600L methanol for the second extraction;

[0042] 2) Combine the extracts, concentrate the extracts at 70°C under normal pressure to 100L, release the concentrate and cool to room temperature; filter to obtain coarse crystals of mangiferin with a purity of 80% and a mass of 2.9kg;

[0043] 3) The crude crystals were washed with 30L of ethyl acetate to remove ester-soluble impurities, and filtered to obtain a yellow solid with a purity of 90% and a mass of 2.46kg;

[0044] 4) Heat and dissolve the yellow crystals with 200L 50% alcohol, keep warm at 75°C for 30min, add 0.2kg of activated c...

Embodiment 2

[0046] With embodiment 1, difference is that step 1) takes pulverized almond leaf 100kg (mangiferin content about 3%), finally obtains light yellow crystal, purity is 98.81%, quality 2.11kg.

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Abstract

The invention belongs to the technical field of plant extraction, and relates to mangiferin and a preparation method thereof. The method comprises the following step that: activated carbon treatment and extraction are sequentially carried out on raw materials to obtain mangiferin, the raw materials are mango leaves and / or almond leaves, the extraction is absolute methanol extraction, and the extraction temperature is 60-65 DEG C. Results show that the purity of the mangiferin prepared by the preparation method of the mangiferin provided by the invention is 98-99.5%, and the yield of the mangiferin is up to 66.7% of the total mangiferin content in mango leaves or almond leaves. The preparation method of the mangiferin is simple to operate, and the production cost of the mangiferin is reduced while high-yield and high-purity mangoes are obtained; and the industrial production of the mangiferin is realized by utilizing specific production equipment.

Description

technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a mangiferin and a preparation method thereof. Background technique [0002] The molecular formula of Mangiferin (MGF) is C 16 h 12 o 4 , mainly exists in the fruits, leaves, and bark of mangoes of Anacardiaceae, rhizomes and aerial parts of Anemarrhena liliaceae, and dried flowers and leaves of Iridaceae plants. Mangiferin has various physiological activities such as anti-tumor, anti-virus, anti-oxidation, and anti-diabetes. Due to its safety, it has a good development prospect. However, due to the weak solubility and transmembrane permeability of MGF, the bioavailability is low. , thus restricting the pharmacological effects of MGF. [0003] Mango leaf is the leaf of Anacardiaceae mango, which is abundant in Guangxi and is the main raw material for the production of mango cough tablets. Studies have shown that mangiferin is the main active ingredient i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D407/04
CPCC07D407/04C07B2200/13C07B2200/07C07H1/08C07H17/04
Inventor 邹雨池陈金峰
Owner 西安金泰生物技术有限公司
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