Triazaamidine sustained-release injection and preparation method thereof

Abstract

The invention discloses a triazamidine sustained-release injection and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The active ingredient of the injection is triazamidine. Compared with common triazamidine for injection, the triazamidine sustained-release injection has the advantages that after the injection is diluted with water for injection and shaken up with force, the system can be converted into an oil phase and water phase mutual encapsulated emulsion, the sustained-release effect is achieved, the drug effect time is prolonged, the blood drug peak concentration is lower, drug poisoning is not likely to occur, and the drug safety is improved. Meanwhile, the irritation of the drug to tissue is significantly reduced, and the animal stress is reduced. The preparation technology is high in operability, production and conversion of the product are facilitated, and application and popularization are convenient.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a triazamidine sustained-release injection and a preparation method thereof. Background technique [0002] Triazamidine is an anti-insect drug that has a strong inhibitory effect on piriformis, trypanosoma, eperythrozoon, etc. The raw material is yellow or orange, odorless, unstable when exposed to light and heat, and can turn orange Red, it is mainly used in veterinary clinics for the treatment of infections such as Piroplasma babesia, Piroplasma theileria, Trypanosoma evanii, Trypanosomiasis, Eperythrozoon, etc. Drug of choice. Although the drug has been promoted and applied clinically, its market value has not yet been fully utilized. The main reason is that there is only one dosage form of injection powder injection at present, and the blood concentration of this dosage form rises very quickly after the drug is administered to animals, and it...

AI Technical Summary

Problems solved by technology

Although the drug has been promoted and applied clinically, its market value has not yet been fully utilized. The main reason is that there is only one dosage form of injection powder injection at present, and the blood concentration of this dosage form rises very quickly after the drug is administered to animals, and it is easy to exceed the body. The threshold range that can be tolerated is poisoned, and the duration of the drug effect is not long. It takes repeated administration in a single day to maintain an effective blood drug concentration for a long time. This is not only time-consuming and laborious, but also stressful to animals. Many animals The feed intake cannot return to normal within 24 to 72 hours after taking the medicine, which has a lot to do with the side effects of the medicine itself

In addition, the drug itself is highly irritating, and the local area is prone to inflammation after injection, and even tissue degeneration, inflammation, redness, swelling and other problems appear.

These are the main reasons why the drug cannot fully exert its promotional value in the first-line clinic

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