Triazaamidine sustained-release injection and preparation method thereof

A technology of sustained-release injections and triazamidine, which is applied in the direction of pharmaceutical formulas, medical preparations with no active ingredients, medical preparations containing active ingredients, etc. The effect duration is not long, etc., to achieve the effect of facilitating production transformation, facilitating popularization and application, and reducing irritation

Active Publication Date: 2021-09-24
谢彩华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the drug has been promoted and applied clinically, its market value has not yet been fully utilized. The main reason is that there is only one dosage form of injection powder injection at present, and the blood concentration of this dosage form rises very quickly after the drug is administered to animals, and it is easy to exceed the body. The threshold range that can be tolerated is poisoned, and the duration of the drug effect is not long. It takes repeated administration in a single day to maintain an effective blood drug concentration for a l

Method used

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  • Triazaamidine sustained-release injection and preparation method thereof
  • Triazaamidine sustained-release injection and preparation method thereof
  • Triazaamidine sustained-release injection and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1-10

[0023] In order to make the description concise, the weight composition of a triazamidine sustained-release injection described in Examples 1-10 is given in the form of a table below, as shown in Table 1 for details.

[0024] Each component of table 1 embodiment 1-10 is made up (total 100ml capacity)

[0025]

[0026] Embodiment 1-10 A preparation method of triazamidine sustained-release injection, comprising the following steps:

[0027] a) Mix the surfactant and oil in the formulated amount, heat to 38-50°C, and the system turns into a liquid;

[0028] b) Add triazine, stir evenly, and cool to room temperature, the system turns into a solid paste, which is aseptically packaged to obtain the product.

[0029] Effect experiment 1 verification of the properties of the product of the present invention

[0030] The product obtained by the present invention is a yellow paste solid at normal temperature, has strong wall adhesion, and does not fall off the wall after being inve...

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Abstract

The invention discloses a triazamidine sustained-release injection and a preparation method thereof, and belongs to the technical field of veterinary drug preparations. The active ingredient of the injection is triazamidine. Compared with common triazamidine for injection, the triazamidine sustained-release injection has the advantages that after the injection is diluted with water for injection and shaken up with force, the system can be converted into an oil phase and water phase mutual encapsulated emulsion, the sustained-release effect is achieved, the drug effect time is prolonged, the blood drug peak concentration is lower, drug poisoning is not likely to occur, and the drug safety is improved. Meanwhile, the irritation of the drug to tissue is significantly reduced, and the animal stress is reduced. The preparation technology is high in operability, production and conversion of the product are facilitated, and application and popularization are convenient.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a triazamidine sustained-release injection and a preparation method thereof. Background technique [0002] Triazamidine is an anti-insect drug that has a strong inhibitory effect on piriformis, trypanosoma, eperythrozoon, etc. The raw material is yellow or orange, odorless, unstable when exposed to light and heat, and can turn orange Red, it is mainly used in veterinary clinics for the treatment of infections such as Piroplasma babesia, Piroplasma theileria, Trypanosoma evanii, Trypanosomiasis, Eperythrozoon, etc. Drug of choice. Although the drug has been promoted and applied clinically, its market value has not yet been fully utilized. The main reason is that there is only one dosage form of injection powder injection at present, and the blood concentration of this dosage form rises very quickly after the drug is administered to animals, and it...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/655A61K47/14A61K47/26A61K47/44A61P33/02A61P31/04
CPCA61K31/655A61K9/1075A61K9/0019A61K47/26A61K47/14A61K47/44A61P33/02A61P31/04
Inventor 谢彩华杨红玉吴飞燕史威威杨志健丁立丁利民蒋雨宏张敏
Owner 谢彩华
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