Polymer microneedle and preparation method thereof

A polymer and polymer solution technology, applied in the field of biomedical materials, can solve the problems of affecting the quality and use effect of polymer microneedles, limiting the mechanical properties of polymer microneedles, poor mechanical properties, etc., to achieve enhanced transdermal efficiency, Improves mechanical properties and improves moisture retention

Pending Publication Date: 2021-09-28
惠州市微针科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, a major disadvantage of polymer microneedles is that the polymers used must be pharmaceutical polymer excipients, which greatly limits the mechanical properties that polymer microneedles can withstand.
That is to say, the existing polymer microneedles generally have the problem of poor mechanical properties due to material limitations; so that the polymer microneedle arrays are prone to problems such as microneedle breakage during transportation and storage or during use, affecting The quality and application effect of polymer microneedles

Method used

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  • Polymer microneedle and preparation method thereof
  • Polymer microneedle and preparation method thereof
  • Polymer microneedle and preparation method thereof

Examples

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Effect test

Embodiment 1

[0041] In this example, polyvinylpyrrolidone polymer microneedles doped with different concentrations of silk fibroin were prepared, and the effects of different concentrations of silk fibroin doping on the performance of polymer microneedles were analyzed, as follows:

[0042] 1) Pretreatment of silk fibroin: Weigh 10g of silk protein powder and suspend it in 400mL of 0.5% NaHCO 3 solution, after soaking at room temperature for 24 hours, stirring and degumming in a water bath at 100°C for 2 hours; after the above solution was vacuum filtered, the filter cake was resuspended in 400mL of CaCl 2 、H 2 In a mixed solvent of O and absolute ethanol (EtOH), stir and soak at room temperature for 48 hours; raise the temperature of the water bath to 100°C and maintain for 2 hours to dissolve. Transfer the above solution to a cellulose dialysis bag (2 ; The solution in the above-mentioned dialysis bag is freeze-dried to obtain the water-soluble silk fibroin of this example. Among them,...

Embodiment 2

[0047] In this example, sodium hyaluronate polymer microneedles doped with different concentrations of silk fibroin were prepared, and the effects of different concentrations of silk fibroin doping on the performance of polymer microneedles were analyzed, as follows:

[0048] 1) Pretreatment of silk fibroin: Weigh 10g of silk protein powder and suspend it in 400mL of 0.5% NaHCO 3 solution, after soaking at room temperature for 24 hours, stirring and degumming in a water bath at 100°C for 2 hours; after the above solution was vacuum filtered, the filter cake was resuspended in 400mL of CaCl 2 、H 2 In a mixed solvent of O and absolute ethanol (EtOH), stir and soak at room temperature for 48 hours; raise the temperature of the water bath to 100°C and maintain for 2 hours to dissolve. Transfer the above solution to a cellulose dialysis bag (2 ; The solution in the above-mentioned dialysis bag is freeze-dried to obtain the water-soluble silk fibroin of this example. Among them, C...

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Abstract

The invention discloses a polymer microneedle and a preparation method thereof. The polymer microneedle is prepared from a polymer solution doped with silk fibroin. According to the polymer microneedle disclosed by the invention, on one hand, the silk fibroin is added into the polymer microneedle, so that the mechanical property of the polymer microneedle is enhanced, the moisture retention is improved, the dissolution rate of the polymer microneedle can be regulated and controlled, and the release effect can be controlled; on the other hand, the silk fibroin doped in the polymer microneedle can penetrate through the cuticle of the skin, so that the problems of low transdermal rate and poor effect of the existing mask, emulsion or cream containing the silk fibroin are solved; the polymer microneedle doped with the silk fibroin enhances the transdermal efficiency of the silk fibroin and has a better cosmetic effect.

Description

technical field [0001] The present application relates to the field of biomedical materials, in particular to a polymer microneedle and a preparation method thereof. Background technique [0002] Microneedle drug delivery technology is a new type of minimally invasive drug delivery technology developed in the field of biomedicine. The thickness of the stratum corneum of the skin is usually 10 μm-20 μm. Microneedle drug delivery technology uses microneedles with a height of 50 μm-1000 μm to pierce the human stratum corneum to form a channel that is conducive to drug delivery, thereby promoting transdermal absorption of drugs; microneedles It can penetrate the stratum corneum of the skin, but has not yet reached the deep layer of the skin rich in nerve endings, so it does not produce pain. Microneedle drug delivery has the characteristics of painless, minimally invasive, efficient, no first-pass effect, and convenient delivery. It has become a research hotspot in the field of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/42A61K47/32A61K47/36A61K38/17A61P17/00A61M37/00
CPCA61K9/0021A61K47/42A61K47/32A61K47/36A61K38/1767A61P17/00A61M37/0015A61M2037/0046A61M2037/0053
Inventor 吕方宇何盛南沈再阳
Owner 惠州市微针科技有限公司
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