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Preparation method of anisotropic hydrogel

An anisotropic, hydrogel technology, applied in the field of multifunctional hydrogel preparation, can solve the problems of limited application of hydrogel, lack of ordered structure, etc., and achieve the effect of good biocompatibility, high strength and toughness

Active Publication Date: 2021-10-01
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, compared with biological soft tissues, hydrogels synthesized by traditional methods exhibit isotropic structures at the molecular and macroscopic levels, and lack ordered structures, which limits the application of hydrogels in various fields.

Method used

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  • Preparation method of anisotropic hydrogel
  • Preparation method of anisotropic hydrogel

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preparation example Construction

[0024] A kind of preparation method of anisotropic hydrogel of the present invention, specifically implement according to the following steps:

[0025] Step 1, mixing gelatin with deionized water, putting it into a constant temperature oscillator for reaction, making it fully dissolved, and obtaining a gelatin solution;

[0026] The mass ratio of gelatin to deionized water is 0.1-4:2-5;

[0027] The reaction temperature is 30-100°C, and the reaction time is 10-120min;

[0028] Step 2, the photoinitiator is dissolved in deionized water to obtain a photoinitiator solution;

[0029] The photoinitiator is diphenylacetone BP, 4-diethylthioxanthone or 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone;

[0030] The mass ratio of photoinitiator to deionized water is 0.0001-1:1-10;

[0031] Step 3, mix the N-isopropylmethacrylamide monomer with deionized water, place it in an ultrasonic shaker to dissolve it, add the crosslinking agent N,N-methylenebisacrylamide after dissolution...

Embodiment 1

[0039] A kind of preparation method of anisotropic hydrogel of the present invention, specifically implement according to the following steps:

[0040] Preliminary preparation: Weigh 1.5g of gelatin into a beaker and dissolve in 3.5mL of deionized water at 40°C for 30 minutes. Then take 10mL of deionized water and stir and dissolve 0.005g of photoinitiator in a glass cup for later use.

[0041] Material treatment: Accurately weigh 0.2g of monomer NIPMAM, add 3mL of deionized water, and place it in an ultrasonic shaker to dissolve for 20min. The mixture solution was poured into the gelatin solution, and stirred slowly for 3 minutes to make it fully mixed.

[0042] Photolithography reaction: Finally, weigh 0.0075g of TG enzyme and dissolve it in 1mL of deionized water, add the enzyme solution dropwise to the mixture until the mixture is completely dissolved and there are basically no more bubbles, then pour it into the mold, and then clamp it on the quartz plate Put the two en...

Embodiment 2

[0044] A kind of preparation method of anisotropic hydrogel of the present invention, specifically implement according to the following steps:

[0045] Preliminary preparation: Weigh 2g of gelatin into a beaker, take 4mL of deionized water and dissolve it at 45°C for 35 minutes. Then take 10mL of deionized water and stir and dissolve 0.01g of photoinitiator in a glass cup for later use.

[0046] Material treatment: Accurately weigh 0.1g of monomer NIPMAM, add 3mL of deionized water, place it in an ultrasonic shaker to dissolve for 40min, add 0.028g of crosslinking agent MBAA after dissolution, and finally add 1mL of photoinitiator solution, mix well; The mixture solution was poured into the gelatin solution, and stirred slowly for 5 minutes to make it fully mixed.

[0047] Photolithography reaction: Finally, weigh 0.01g of TG enzyme and dissolve it in 1mL of deionized water, add the enzyme solution dropwise to the mixture until the mixture is completely dissolved and there ar...

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Abstract

The invention discloses a preparation method of anisotropic hydrogel, and the method specifically comprises the following steps: mixing gelatin with deionized water to obtain a gelatin solution; then mixing an N-isopropyl methacrylamide monomer with deionized water, performing oscillating and dissolving, adding N, N-methylene bisacrylamide and a photoinitiator solution, and performing uniform mixing to obtain a polymer mixed solution; and finally, pouring the polymer mixed solution into the gelatin solution, performing stirring, dropwise adding the enzyme solution into the solution, pouring the solution into a mold after the mixture is completely dissolved without bubbles, performing reacting, and performing cooling to obtain the anisotropic hydrogel. The hydrogel prepared by the preparation method disclosed by the invention has the characteristics of relatively high strength and toughness, anisotropy, no toxicity, no harm and good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of multifunctional hydrogel preparation, and in particular relates to a preparation method of anisotropic hydrogel. Background technique [0002] With the enhancement of people's awareness of environmental protection and the pursuit of renewable energy, green and environmentally friendly products have attracted extensive attention from researchers. Hydrogel is a kind of polymer material composed of physically or chemically cross-linked hydrophilic polymer network and a large amount of water. It is compatible with many tissues in organisms (such as muscle, cartilage, cornea and skin, etc.) With a similar structure, it can be used as an ideal material for artificial organs. However, compared with biological soft tissues, hydrogels synthesized by traditional methods exhibit isotropic structures at the molecular and macroscopic levels, and lack ordered structures, which limits the application of hydrogels in va...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F289/00C08F220/54C08F222/38C08F2/48
CPCC08F289/00C08F2/48C08F220/54C08F222/385
Inventor 朱兴田祎贺斌王学川赵彤孙思薇
Owner SHAANXI UNIV OF SCI & TECH
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