Preparation method of polylactic acid material with anti-adhesion and sterilization functions

A polylactic acid material, anti-adhesion technology, applied in polyester coatings, biocide-containing paints, anti-fouling/underwater coatings, etc., can solve the problems that PLA has no bactericidal performance and cannot meet the requirements, and achieves broad-spectrum and long-term Effective antifouling and antibacterial function, good antibacterial durability, good biocompatibility and environmental friendliness

Active Publication Date: 2021-10-01
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, PLA itself has no bactericidal properties and cannot

Method used

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  • Preparation method of polylactic acid material with anti-adhesion and sterilization functions
  • Preparation method of polylactic acid material with anti-adhesion and sterilization functions
  • Preparation method of polylactic acid material with anti-adhesion and sterilization functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of preparation method of the polylactic acid material with anti-adhesion sterilization function, comprises the following steps:

[0035] (1) 1.2g polylactic acid is dissolved in 24mL methylene chloride, obtains polylactic acid solution, then adds 30mL poor solvent (dehydrated alcohol: n-butanol: butyl acetate volume ratio is 1:1: 1) mixed evenly to obtain a coating solution;

[0036] (2) The coating solution that step (1) obtains is drip-coated on the polylactic acid sheet substrate that thickness is 2mm, and the coating solution on the unit area is 0.3mL / cm 2 , after drying in an oven at 40°C for 48 hours, the surface of the polylactic acid pattern was peeled off using a biaxially oriented polypropylene tape to obtain a superhydrophobic surface;

[0037] (3) Dissolve chlorophyll A in ethanol, sonicate for 3 minutes to prepare a chlorophyll solution with a concentration of 1 μmol / L, and drop-coat the chlorophyll solution onto the superhydrophobic surface obtaine...

Embodiment 2

[0039] A kind of preparation method of the polylactic acid material with anti-adhesion sterilization function, comprises the following steps:

[0040](1) 1.2g polylactic acid is dissolved in 24mL methylene chloride, obtains polylactic acid solution, then adds 30mL poor solvent (dehydrated alcohol: n-butanol: butyl acetate volume ratio is 1:1: 1) mixed evenly to obtain a coating solution;

[0041] (2) The coating solution that step (1) obtains is drip-coated on the polylactic acid sheet substrate that thickness is 2mm, and the coating solution on the unit area is 0.3mL / cm 2 , after drying in an oven at 40°C for 48 hours, the surface of the polylactic acid pattern was peeled off using a biaxially oriented polypropylene tape to obtain a superhydrophobic surface;

[0042] (3) Dissolve chlorophyll A in ethanol, sonicate for 3 minutes to prepare a chlorophyll solution with a concentration of 0.5 μmol / L, and drop-coat the chlorophyll solution onto the superhydrophobic surface obtain...

Embodiment 3

[0044] A kind of preparation method of the polylactic acid material with anti-adhesion sterilization function, comprises the following steps:

[0045] (1) 1.2g polylactic acid is dissolved in 24mL methylene chloride, obtains polylactic acid solution, then adds 30mL poor solvent (dehydrated alcohol: n-butanol: butyl acetate volume ratio is 1:1: 1) mixed evenly to obtain a coating solution;

[0046] (2) The coating solution that step (1) obtains is drip-coated on the polylactic acid sheet substrate that thickness is 2mm, and the coating solution on the unit area is 0.3mL / cm 2 , after drying in an oven at 40°C for 48 hours, the surface of the polylactic acid pattern was peeled off using a biaxially oriented polypropylene tape to obtain a superhydrophobic surface;

[0047] (3) Dissolve chlorophyll A in ethanol, sonicate for 3 minutes to prepare a chlorophyll solution with a concentration of 2 μmol / L, and drop-coat the chlorophyll solution onto the superhydrophobic surface obtaine...

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Abstract

The invention discloses a polylactic acid material with anti-adhesion and sterilization functions, which is prepared by the following steps: 1) stirring and dissolving a biodegradable material polylactic acid in a good solvent, adding a poor solvent to realize phase separation, and fully stirring to obtain a coating solution; 2) uniformly coating a polylactic acid sheet with the solution obtained in the step 1), and drying; 3) stripping the top layer polylactic acid by using an adhesive tape to obtain a super-hydrophobic surface; and 4) dispersing chlorophyll in absolute ethyl alcohol, coating on the super-hydrophobic surface of polylactic acid, and drying. The surface of the material has the super-hydrophobic performance of resisting initial adhesion of bacteria, and the adhered bacteria can be killed through photodynamic force. A super-hydrophobic and photodynamic synergistic antibacterial mode is adopted, the dosage of a bactericide is small, the sterilization efficiency is high, the antibacterial long-term effect is good, the controllability is high, and bacteria cannot be induced to generate drug resistance. The polylactic acid material with anti-adhesion and sterilization functions prepared by the invention is non-toxic and harmless, has good biological and environmental compatibility, and can be used in the aspect of bacterial infection resistance of medical or packaging materials.

Description

technical field [0001] The invention relates to the field of anti-bacterial infection, in particular to a preparation method of a polylactic acid material with anti-adhesion and sterilization functions. Background technique [0002] Life and health are related to people's well-being and social harmony. Under the environment of the new crown epidemic sweeping the world, the health needs of the whole people are growing rapidly. According to statistics, nosocomial infection has become the sixth largest "killer". Healthcare-associated infection or nosocomial infection is an infection secondary to the patient's original condition that occurs after receiving treatment in a healthcare facility. About 7% of patients in developed countries suffer from nosocomial infections, and the infection rate in intensive care units is now over 50%. According to the Centers for Disease Control and Prevention, the average cost of treating nosocomial infections has exceeded $200, greatly increasi...

Claims

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Application Information

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IPC IPC(8): C08J7/04C08L67/04C09D5/14C09D167/04C09D7/20
CPCC08J7/042C09D5/14C09D167/04C09D7/20C08J2367/04C08J2467/04
Inventor 王向红王格格陈金周刘旭影杨会歌
Owner ZHENGZHOU UNIV
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