Antibacterial medical suture line and preparation method

A suture and ascorbic acid technology, applied in the field of antibacterial medical suture and preparation, can solve the problems of use limitation, insufficient flexibility, etc., and achieve the effects of less reduction, good water immersion resistance, and good antibacterial durability.

Inactive Publication Date: 2021-02-12
嘉兴市轩禾园艺技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, its use alone as a suture is often limited due to insufficient flexibility, and the complete degradation cycle of PLA is about 12 to 30 months, which is relatively long

Method used

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  • Antibacterial medical suture line and preparation method
  • Antibacterial medical suture line and preparation method
  • Antibacterial medical suture line and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A preparation method of L-ascorbate,

[0045] Preparation of 5,6-O-isopropylidene-L-ascorbic acid: Mix L-ascorbic acid, acetone, and phosphorus oxychloride, and react at 25°C for 5 hours. Washed with water and dried in vacuo to give 5,6-O-isopropylidene-L-ascorbic acid. The addition amount of L-ascorbic acid was 20 wt % of acetone, and the addition amount of phosphorus oxychloride was 5 wt % of acetone.

[0046] Preparation of 3,4-dihydroxyphenylpropionyl chloride: Mix 3,4-dihydroxyphenylpropionic acid and thionyl chloride, react at 50°C for 4h, and concentrate under reduced pressure to remove unreacted Thionyl chloride gives 3,4-dihydroxyphenylpropionyl chloride. The amount of 3,4-dihydroxyphenylpropionic acid added was 10% by weight of thionyl chloride.

[0047] The molecular formula of 3,4-dihydroxyphenylpropionyl chloride is as follows:

[0048]

[0049] In the detection of 3,4-dihydroxyphenylpropionyl chloride by 1H NMR, deuterated acetone was used as solven...

Embodiment 2

[0056] A preparation method of antibacterial medical suture,

[0057] Preparation of skin layer (PLA) particles: Mix hydroxypropyl cellulose, L-ascorbic acid ester obtained in Example 1, PLA, and glutaraldehyde evenly, and blend them on an internal mixer at a temperature of 170 ° C for 10 minutes. After pulverization, the blend particles were obtained by vacuum drying. The amount of L-ascorbate added was 8 wt% of PLA. The amount of hydroxypropyl cellulose added was 8 wt % of PLA. The amount of glutaraldehyde added was 2 wt% of PLA.

[0058] Preparation of composite fiber: Put the skin layer (PLA) particles and the core layer material into the skin layer barrel and the core layer barrel respectively, heat to 175 ℃ to melt, defoaming, spin through a nozzle with a diameter of 1mm to obtain virgin silk, which is obtained by cooling with an aqueous solution The spun silk, the spun silk is respectively drawn once and twice at a temperature of 70°C to obtain a composite fiber. Th...

Embodiment 3

[0061] A preparation method of antibacterial medical suture,

[0062] Preparation of skin layer (PLA) particles: Mix hydroxypropyl cellulose, L-ascorbic acid ester obtained in Example 1, PLA, and glutaraldehyde evenly, and blend them on an internal mixer at a temperature of 170 ° C for 10 minutes. After pulverization, the blend particles were obtained by vacuum drying. The amount of L-ascorbate added was 16 wt% of PLA. The amount of hydroxypropyl cellulose added was 8 wt % of PLA. The amount of glutaraldehyde added was 2 wt% of PLA.

[0063] Preparation of composite fiber: Put the skin layer (PLA) particles and the core layer material into the skin layer barrel and the core layer barrel respectively, heat to 175 ℃ to melt, defoaming, spin through a nozzle with a diameter of 1mm to obtain virgin silk, which is obtained by cooling with an aqueous solution The spun silk, the spun silk is respectively drawn once and twice at a temperature of 70°C to obtain a composite fiber. T...

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Abstract

The invention discloses an antibacterial medical suture line and a preparation method thereof, belongs to the field of medical materials, and particularly relates to an antibacterial medical suture line and a preparation method thereof. The antibacterial medical suture line is obtained by conducting antibacterial finishing on composite fibers of a skin-core structure, wherein the composite fiber comprises hydroxypropyl cellulose, L-ascorbyl ester, a glutaraldehyde skin layer and a PPDO or PLA core layer, and the skin layer also contains PPDO or PLA. The prepared antibacterial medical suture line is good in antibacterial effect; the antibacterial durability is good, and the antibacterial durability effect reaches 5 d or above; the water immersion resistance is good, the reduction amplitudeof the antibacterial effect is small after water immersion is conducted for 24 h, and the antibacterial effect is at least improved by 25% or above.

Description

technical field [0001] The invention belongs to the field of medical materials, in particular to an antibacterial medical suture and a preparation method. Background technique [0002] PPDO is a kind of biodegradable polymer material with good comprehensive performance, good biodegradability and biocompatibility, and high mechanical strength. The molecular chain of PPDO contains groups such as ether bonds, ester bonds and methylene groups. Ester bonds are easily attacked in nature or in living organisms, resulting in chain scission, which endows the material with excellent biodegradability. In addition to ester bonds, the molecular chain of PPDO also contains ether bonds. The presence of ether bonds increases its hydrophilicity and flexibility, and better hydrophilicity also speeds up its degradation. [0003] PPDO molecular chain contains ether bonds, and the glass transition temperature is lower than room temperature, so its flexibility is good, and it also has excellent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/62A01N43/08A01N25/34A01P1/00D01F8/02D01F8/14D01F1/10A61L15/20A61L15/46A61L17/00
CPCA01N25/34A01N43/08A61L15/20A61L15/46A61L17/00A61L17/005A61L2300/406C07D307/62D01F1/103D01F8/02D01F8/14
Inventor 不公告发明人
Owner 嘉兴市轩禾园艺技术有限公司
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