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Preparation method of biodegradable PDT/Fe3O4 composite material

A composite material and biological technology, applied in the field of medical composite materials and its preparation, can solve the problems of biological rejection, poor image sensitivity, biological inertia, etc.

Pending Publication Date: 2021-10-12
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a composite material with good developing properties, excellent degradability and biocompatibility for marking clips, and solve the outstanding problems of poor image sensitivity, biological inertia, and biorejection in traditional metal clips.

Method used

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  • Preparation method of biodegradable PDT/Fe3O4 composite material
  • Preparation method of biodegradable PDT/Fe3O4 composite material
  • Preparation method of biodegradable PDT/Fe3O4 composite material

Examples

Experimental program
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Effect test

preparation example Construction

[0085] Typically, the preparation method of the present invention includes the steps of:

[0086] (S1) Mix the tetraned iron nanoparticles, biodegradable and biocompatible polymers, and the first solvent to form a first mixture, wherein the biodegradable and biocompatible polymers are in the first solvent. It is soluble;

[0087] (S2) Add a second solvent to the first mixture, thereby forming a complex of the tetrasoxide nanoparticles and biodegradable and biocompatible polymers; and

[0088] (S3) The precipitate was separated and dried to obtain a composite according to claim 1.

[0089] Preferably, the composite material of the present invention is PDT / Fe 3 O 4 Composite.

[0090] In a preferred example, the present invention provides a preparation of PDT / Fe 3 O 4 The method of the composite material includes the following steps:

[0091] (1) Synthesis of PDT

[0092] S1.1, the ratio of the monomer extrapolatomy amylide (DLLA) and the tri methylene carbonate (TMC) material i...

Embodiment 1

[0127] Example 1. Different matching PDT preparation

[0128] 1.1. Method

[0129] In the present embodiment, a polymer having a mixing ratio of a mixed proportion of extracted amphorodoxide (DLLA) and trikarcarbonate (TMC) was prepared, and compared properties. Methods as below:

[0130] (a) Take a certain amount of monomer-free lease (DLLA) and TMC (TMC), the ratio of the substances of both is 100: 0, 98: 2, 95: 5, 90 : 10,85: 15,80: 20,70: 30 and 0: 100;

[0131] (b) Select catalyst octoctanate Sn (OCT) 2 The ratio of the total mass of the monomer is 1.25: 1000;

[0132] (c) After the vacuum was 4 h, it was raised to 120 in an argon atmosphere, and the reaction was 6 h;

[0133] (d) The above product was dissolved by dichloromethane and anhydrous ether 2 to 3 times, and the PDT sample was evaporated in vacuo to 150 ° C.

[0134] (e) The above product was stored in a refrigerator of -20 ° C with an aluminum foil.

[0135] Such as Figure 1-2 As shown, the results show that the co...

Embodiment 2

[0139] Example 2. PDT material 3D printing

[0140] Example 1 was repeated, and the ratio of the substance of the monomer extracted amphorodoxide (DLLA) and a trimethylene carbonate (TMC) was 70:30, and anhydrous in step (d) Ethanol is replaced by waterless diethyl ether. After 3D printing, Figure 4 The product shown. Depend on Figure 4 It can be seen that the PDT material has the properties of the printed molding in the form of the substance of the monomer extracted amphorodoxide (DLLA) and trikylene carbonate (TMC). Properties of 70:30.

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Abstract

The invention relates to the field of medical composite materials, and discloses a poly (racemic lactide-trimethylene carbonate) / nano ferroferric oxide (PDT / Fe3O4) composite material with biocompatibility and biodegradability and a preparation method thereof. The preparation method comprises the following steps of: compounding synthesized PDT and a certain amount of magnetic nano Fe3O4 in an organic solvent by means of mechanical stirring, precipitating, and drying in vacuum; and performing hot-pressing by using a press vulcanizer to obtain a sheet. The PDT-Fe3O4 composite material synthesized by the method of the invention belongs to a flexible material, and has good imaging function, bioabsorbability and biodegradability in order to solve the prominent problems of poor developing sensitivity, biological inertness, rejection reaction and the like of a traditional metal marking clip.

Description

Technical field [0001] The present invention relates to the field of nanometric composites, and in particular to a medical composite material having good imaging function, biological absorbability and biodegradability and a preparation method thereof. Background technique [0002] In recent years, the incidence of breast cancer is high, the first place in the incidence of female malignant tumors in breast cancer in the global scale. In various tumor diseases, breast cancer is the first killer facing women. Reserved breast treatment of breast cancer after reserved radiation treatment to reduce local recurrence risks, where the whole milk irradiation, WBI is the dominant model of postoperative radiotherapy, but in recent years, the data shows that for early breast cancer patients, Partial Breast IrraDiation, PBI, like WBI, can reduce local recurrence rate, while radiotherapy adverse reactions and beauty effects, PBI can replace WBI to a certain extent, and the key to achieving PBI ...

Claims

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Application Information

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IPC IPC(8): C08L67/04C08L69/00C08K3/22C08J3/20C08G63/64C08G63/78A61L31/04A61L31/06A61L31/02A61L31/18A61L31/14A61L31/16A61K47/36A61K47/34A61K41/00A61P35/00A61K49/04
CPCC08K3/22C08J3/205C08G63/64C08G63/78A61L31/042A61L31/06A61L31/028A61L31/18A61L31/148A61L31/16A61K47/36A61K47/34A61K41/0052A61P35/00A61K49/04C08K2003/2275C08K2201/01C08K2201/011C08L2201/06C08J2367/04C08J2369/00C08L67/04C08L69/005
Inventor 刘昌胜李玉林罗炜刘天舒
Owner EAST CHINA UNIV OF SCI & TECH
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