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Abiraterone acetate suppository and preparation method thereof

A technology of abiraterone acetate and suppositories, which is applied in the field of medicine, can solve the problems of high bioavailability and failure to provide, and achieve the effects of simple preparation process, improved bioavailability, and small individual differences

Pending Publication Date: 2021-10-26
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] In the prior art, none of them can provide a well-absorbed and highly bioavailable abiraterone acetate preparation

Method used

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  • Abiraterone acetate suppository and preparation method thereof
  • Abiraterone acetate suppository and preparation method thereof
  • Abiraterone acetate suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Component content

[0032] Aistelon 100g

[0033] Stealic acid polya carbide 1500g

[0034] Preparation Process:

[0035] The calculation is used to measure the stearate polyaptoalkoxide, heating melts, and adds the amount of acetate at the same amount of acetate, stirring, and dissolving, filled on the suppository filling line.

Embodiment 2

[0037] Component content

[0038] Aistelon 100g

[0039] Stealic acid polyaptoxate 1000g

[0040] Preparation Process:

[0041] The calculation is used to measure the stearate polyaptoalkoxide, heating melts, and adds the amount of acetate at the same amount of acetate, stirring, and dissolving, filled on the suppository filling line.

Embodiment 3

[0043] Component content

[0044] Aistelon 100g

[0045] Stealic acid polyluorodoxide 2000g

[0046] Preparation Process:

[0047] The calculation is used to measure the stearate polyaptoalkoxide, heating melts, and adds the amount of acetate at the same amount of acetate, stirring, and dissolving, filled on the suppository filling line.

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PUM

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to an abiraterone acetate suppository and a preparation method thereof. The abiraterone acetate suppository disclosed by the invention comprises abiraterone acetate and a matrix. The preparation method comprises the following steps: weighing a prescription quantity of matrix, performing heating for melting, adding a prescription quantity of abiraterone acetate, performing stirring for dissolving, and performing filling on a suppository filling line to obtain the abiraterone acetate suppository. Compared with the prior art, the abiraterone acetate suppository has the advantages that the bioavailability is greatly improved, and the preparation process is simple and suitable for industrial mass production.

Description

Technical field [0001] The invention belongs to the field of medical technology, and more particularly to a acetate Abite Pubic, which is made of a preparation method thereof. Background technique [0002] Abiraterone acetate is an oral effective CYP17 enzyme inhibitor developed by Centocor Ortho, USA, approved by the US FDA in April 2011, clinical and prednisone-used treatment to resist Castration Resistant Prostatecancer, CRPC). This product is the selective oral inhibitor of the key enzyme 17α-hydroxylase-C17, 20-lysed enzyme (human cytochrome P45017 enzyme) in testosterone synthesis, and can reduce the level of tumor marker prostate antigen (PSA), available Patients with prostate cancer that have continued growth in tumors have been employed by drug treatment or surgery. Apiton is known as 3β-acetyloxy-17- (3-pyridyl) - -5,16-diene, molecular formula C 26 Hide 33 NO 2 , Molecular weight 391.55, the chemical structure is: [0003] [0004] A biton acetate is white or white n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K47/10A61K47/34A61K47/42A61P35/00
CPCA61K9/02A61K47/10A61K47/34A61K47/42A61P35/00
Inventor 郝贵周尚萍萍
Owner LUNAN PHARMA GROUP CORPORATION
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