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Detection method of norfloxacin based on MOFs (Metal-Organic Frameworks) type molecularly imprinted polymer

A kind of technology of norfloxacin and detection method, applied in the detection field of norfloxacin

Active Publication Date: 2021-10-29
FOSHAN SANSHUI FOSHUI WATER SUPPLY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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  • Detection method of norfloxacin based on MOFs (Metal-Organic Frameworks) type molecularly imprinted polymer
  • Detection method of norfloxacin based on MOFs (Metal-Organic Frameworks) type molecularly imprinted polymer
  • Detection method of norfloxacin based on MOFs (Metal-Organic Frameworks) type molecularly imprinted polymer

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Embodiment 1

[0051] Embodiment 1: the detection method of norfloxacin in the actual water sample

[0052] Follow the steps below to detect norfloxacin in actual water samples:

[0053] S1: Prepare MOFs-type molecularly imprinted polymer UiO-66@MIP according to the following steps:

[0054] S1a: Preparation of UiO-66-NH 2 As a carrier for molecular imprinting: 0.78g ZrCl 4 and 5.55 mL of acetic acid were dissolved in 80 mL of DMF by sonication for 5 min. Then, 0.58 g of 2-aminoterephthalic acid was dissolved in the solution. After an additional 5 min of sonication, 0.24 mL of deionized water was added to the solution. The mixed solution was transferred to a polytetrafluoroethylene reactor, heated to 120° C. for 24 hours, and then cooled to room temperature. The product was washed repeatedly with DMF and ethanol, and then dried under vacuum at 60 °C.

[0055] S1b: Through the reaction of anhydride and amino group, in UiO-66-NH 2 Grafting double bonds on the surface to synthesize UiO-6...

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Abstract

The invention discloses a detection method of norfloxacin based on an MOFs (Metal-Organic Frameworks) type molecularly imprinted polymer. The detection method comprises the following steps: S1, preparing the MOFs type molecularly imprinted polymer UiO-66 (at) MIP; S2, establishing a norfloxacin liquid phase standard working curve; S3, detecting an actual water sample: mixing the actual water sample with the UiO-66-coated MIP prepared in the step S1, incubating on an oscillator at 500rpm for 40 minutes, and centrifuging to remove supernate; then adding an eluent, and collecting the eluent after ultrasonic centrifugation; and extracting a norfloxacin aqueous solution, concentrating the eluent by a nitrogen blowing concentrator, fixing the volume to the initial actual water sample volume by using water, detecting the obtained aqueous solution by using high performance liquid chromatography, determining whether the norfloxacin is contained or not by using dead time, and substituting the peak area into a norfloxacin liquid phase standard working curve to calculate the content of the norfloxacin in the actual water sample. According to the detection method, the detection cost and the operation difficulty of norfloxacin are effectively reduced, and meanwhile, the detection efficiency is improved.

Description

technical field [0001] The invention belongs to the field of antibiotic detection, and in particular relates to a detection method of norfloxacin based on MOFs type molecularly imprinted polymers. Background technique [0002] Norfloxacin (NOR) is a kind of quinolone antibiotics. As a broad-spectrum and cheap antibiotic, it is widely used in the treatment and control of diseases in human and animal products. According to incomplete statistics, the consumption of antibiotics in my country exceeds 50% of the total consumption in the world, which has caused many problems. It is not uncommon for antibiotics to be detected in lakes and rivers as they are only partially metabolized and large quantities of antibiotics are excreted into the environment in feces and urine. And drinking water containing antibiotics for a long time will lead to the decline of human immunity, the imbalance of intestinal flora, and even carcinogenic and teratogenic. Therefore, it is imminent to develop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/12G01N30/32G01N30/34G01N30/74G01N30/86
CPCG01N30/02G01N30/06G01N30/12G01N30/32G01N30/34G01N30/74G01N30/8679G01N2030/062G01N2030/065G01N2030/324G01N2030/862Y02A50/30
Inventor 黄泽宇许泽彬刘婉琼林立斌梁晓琳
Owner FOSHAN SANSHUI FOSHUI WATER SUPPLY CO LTD
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