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Biological essence polypeptide composition as well as preparation method and application of lipidosome nanocrystallization of biological essence polypeptide composition

A technology of polypeptide composition and biological polypeptide, which can be applied in the direction of cosmetic preparations, skin care preparations, medical preparations containing active ingredients, etc., and can solve the problems of not causing cosmetics, poor stability, etc.

Pending Publication Date: 2021-11-02
北京清大赛尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, multifunctional small molecule peptides have been mainly chemically synthesized, and most of the secondary synthetic peptides have poor stability and are easy to degrade (especially in solution), but the above problems have not attracted the attention of the cosmetics industry

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The invention proposes a biological polypeptide composition, comprising: oligopeptide-1, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7 and water.

[0031] In an optional embodiment, the material components of the biological polypeptide composition include: oligopeptide-1: 0.02%-2%; tripeptide-1: 0.02%-2%; hexapeptide-9 For: 0.02%-4%; Palmitoyl Pentapeptide-4: 0.01%-1%; Palmitoyl Tripeptide-5: 0.01%-1%; Palmitoyl Tetrapeptide-7: 0.01%-1%; The remainder is: water.

[0032] In an optional embodiment, the material components of the biological polypeptide composition include: oligopeptide-1: 0.5%; tripeptide-1: 0.5%; hexapeptide-9: 2%; Acyl pentapeptide-4: 0.2%; palmitoyl tripeptide-5: 0.2%; palmitoyl tetrapeptide-7: 0.2%; the rest: water.

Embodiment 2

[0034] With reference to the biological polypeptide composition proposed in Example 1, the present invention proposes a biological polypeptide nano composition liposome, comprising a polypeptide composition, component A and water, and component A comprises a lipid wall material, an emulsifier, a bile sterols and polyols;

[0035] The liposome of biological polypeptide nano composition comprises the following components according to the mass percentage: oligopeptide-1: 0.02%-2%; tripeptide-1: 0.02%-2%; hexapeptide-9: 0.02%-4 %; palmitoyl pentapeptide-4: 0.01%-1%; palmitoyl tripeptide-5: 0.01%-1%; palmitoyl tetrapeptide-7: 0.01%-1%; lipid wall material: 3%-30%; emulsifier: 2%-20%; cholesterol: 3%-10%; polyol: 25%-50%; the rest: water.

[0036] In an optional embodiment, in component A:

[0037] The lipid wall material is one or more of hydrogenated lecithin, soybean lecithin, egg yolk lecithin and hydroxylated lecithin;

[0038] The emulsifiers are: Steareth-21, Glyceryl Myri...

Embodiment 3

[0041] With reference to the polypeptide nano composition liposome proposed in embodiment 2, the present invention proposes the preparation method of polypeptide nano composition liposome, comprises the following steps:

[0042] S1: Obtain plant essence component B; component B includes: seaweed polysaccharide, Moutan bark extract, Scutellaria baicalensis extract, arbutin, Fangji extract, gentian extract, citrus extract, chamomile flower extract, Polygonum cuspidatum extract and centella asiatica extract;

[0043] S2: Mix component B with water and dissolve it at 70-80°C, then cool down to 40-50°C to obtain the first water phase;

[0044] S3: mixing oligopeptide-1, tripeptide-1, and hexapeptide-9 with water, and dissolving at 30-50°C to obtain a second aqueous phase;

[0045] S4: Mix lipid wall material, cholesterol, and emulsifier, dissolve at 70-80°C, cool down to 30-50°C, and add polyol, palmitoyl pentapeptide-4, palmitoyl tripeptide- 5. Mix palmitoyl tetrapeptide-7 and dis...

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Abstract

The invention relates to a biological essence and polypeptide composition as well as technical preparation and application of lipidosome nanocrystallization of the biological essence and polypeptide composition. The composition is prepared from oligopeptide-1, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, algal polysaccharides, a moutan bark extract, a radix scutellariae extract, arbutin, a stephania tetrandra extract, a radix gentianae extract, a citrus extract, a chamomilla recutita flower extract, a polygonum cuspidatum extract, a centella asiatica extract and water. According to the invention, human skin tests show that facial skin problems, such as darkness, stains, wrinkles and the like, can be remarkably improved, and the compound liposome of the plant essence and the polypeptide composition has the effect of remarkably improving the skin problems.

Description

technical field [0001] The invention relates to the field of liposome nanometerization, in particular to the preparation and application of liposome nanometerization of plant essence and polypeptide composition. Background technique [0002] Compared with other parts of the body, the face is more obvious and more likely to expose the aging state of the skin. [0003] Because the structure of multifunctional small molecular peptides is very similar to that of human physiological components, it has strong anti-wrinkle and anti-oxidation effects and is easily absorbed by the skin. It has been widely used in the existing technical problems in the medical and aesthetic industry. [0004] At present, the multifunctional small molecular peptides have been mainly chemically synthesized, and most of the secondary synthetic peptides have poor stability and are easy to degrade (especially in solution), but the above problems have not attracted the attention of the cosmetics industry. ...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/9789A61K8/60A61K8/73A61K8/14A61Q19/08
CPCA61K8/64A61K8/14A61K8/73A61K8/9789A61K8/602A61Q19/08A61K2800/5922
Inventor 潘元明李俊
Owner 北京清大赛尔生物科技有限公司
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