Biological essence polypeptide composition as well as preparation method and application of lipidosome nanocrystallization of biological essence polypeptide composition

A technology of polypeptide composition and biological polypeptide, which can be applied in the direction of cosmetic preparations, skin care preparations, medical preparations containing active ingredients, etc., and can solve the problems of not causing cosmetics, poor stability, etc.

Pending Publication Date: 2021-11-02
北京清大赛尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, multifunctional small molecule peptides have been mainly chemically synthesized, and most of the secondary synthetic peptides hav

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1:

[0030] The present invention proposes a biopolypeptide composition comprising: oligopeptide-1, trionylene peptide-1, hexapeptide-9, palmitum pentameptide-4, palmitum trionylene peptide-5, palmitum tetrapeptide -7 and water.

[0031] In an alternative embodiment, the substance component of the biothyreopeptide composition includes: oligopeptide -1 is: 0.02% -2%; tripeptide-1 is: 0.02% -2%; hexide-9 To: 0.02% -4%; palmityl pentin-4 is: 0.01% -1%; palmitum trionamer-5 is: 0.01% -1%; palmitum tetral peptide -7 is: 0.01% -1%; The rest is: water.

[0032] In an alternative embodiment, the substance component of the biothyreopeptide composition includes: oligopeptide -1 is: 0.5%; tripeptide-1 is: 0.5%; hexapeptide -9 is: 2%; palm Acid 5 peptide-4 is: 0.2%; palmitum trionutide-5 is: 0.2%; palmitum tetral peptide -7 is: 0.2%; the rest is: water.

Example Embodiment

[0033] Example 2:

[0034] Referring to the bioopolypeptide composition proposed in Example 1, the present invention proposes a biopolypeptide nano-composition liposome, including a polypeptide composition, component A, and water, component A including lipid wall, emulsifier, gallbladder Sterol and polyol;

[0035] Biological polypeptide nano-composition liposomes include the following components: oligopeptide-1 is: 0.02% -2%; tripeptide-1 is: 0.02% -2%; hexapeptide -9 is: 0.02% -4 %; Palmityl pentin-4 is: 0.01% -1%; palmitum trionutide-5 is: 0.01% -1%; palmitum tetrapeptide -7 is: 0.01% -1%; lipid wall material: 3% -30%; emulsifiers: 2% -20%; cholesteric: 3% -10%; polyols: 25% -50%; the rest: water.

[0036] In an alternative embodiment, the component A:

[0037] Lipid walls are: one or more of hydrogenated lecithin, soy lecithin, egg yolk lecithin, and hydroxylated lecithin;

[0038] Emulsifier is: stearyl alcohol polyether-21, glycolis, Tween-80, cetyl alcohol polyether-25, pol...

Example Embodiment

[0040] Example 3:

[0041] The present invention proposes the preparation method of the polypeptide nano-composition liposome, including the following steps:

[0042] S1: Get Plant Essence Components B; Component B includes: seaweed polysaccharide, peony skin extract, astragal aerial extract, xero fruit, powder anti-self-extract, gallbladder extract, citrus extract, maternal chrysanthemum extract, tiger stick Extracts and snowgrass extracts;

[0043] S2: Mix the component B with water and dissolved under 70-80 ° C, then cooled to 40-50 ° C to give the first aqueous phase;

[0044] S3: Mix the oligopeptide-1, tripeptide-1, hexide-9 and water, dissolved under 30-50 ° C, to obtain a second aqueous phase;

[0045] S4: Mix the grease wall material, cholesteric, emulsifier, dissolved under 70-80 ° C, cooled to 30-50 ° C, and to add polyol, palmityl psytotapeptide-4, palmitum tropipe peptide - 5. Mixing of palmitum tetrapeptide-7, dissolved under 30-50 ° C, to obtain an oil phase.

[0046...

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Abstract

The invention relates to a biological essence and polypeptide composition as well as technical preparation and application of lipidosome nanocrystallization of the biological essence and polypeptide composition. The composition is prepared from oligopeptide-1, tripeptide-1, hexapeptide-9, palmitoyl pentapeptide-4, palmitoyl tripeptide-5, palmitoyl tetrapeptide-7, algal polysaccharides, a moutan bark extract, a radix scutellariae extract, arbutin, a stephania tetrandra extract, a radix gentianae extract, a citrus extract, a chamomilla recutita flower extract, a polygonum cuspidatum extract, a centella asiatica extract and water. According to the invention, human skin tests show that facial skin problems, such as darkness, stains, wrinkles and the like, can be remarkably improved, and the compound liposome of the plant essence and the polypeptide composition has the effect of remarkably improving the skin problems.

Description

technical field [0001] The invention relates to the field of liposome nanometerization, in particular to the preparation and application of liposome nanometerization of plant essence and polypeptide composition. Background technique [0002] Compared with other parts of the body, the face is more obvious and more likely to expose the aging state of the skin. [0003] Because the structure of multifunctional small molecular peptides is very similar to that of human physiological components, it has strong anti-wrinkle and anti-oxidation effects and is easily absorbed by the skin. It has been widely used in the existing technical problems in the medical and aesthetic industry. [0004] At present, the multifunctional small molecular peptides have been mainly chemically synthesized, and most of the secondary synthetic peptides have poor stability and are easy to degrade (especially in solution), but the above problems have not attracted the attention of the cosmetics industry. ...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/9789A61K8/60A61K8/73A61K8/14A61Q19/08
CPCA61K8/64A61K8/14A61K8/73A61K8/9789A61K8/602A61Q19/08A61K2800/5922
Inventor 潘元明李俊
Owner 北京清大赛尔生物科技有限公司
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