Unlock instant, AI-driven research and patent intelligence for your innovation.

White mustard seed extract as well as preparation method and application thereof

The technology of white mustard seeds and extracts is applied in the field of biomedicine, which can solve the problems of general curative effect and discomfort for long-term use, and achieve the effect of strong inhibitory activity and small side effects.

Pending Publication Date: 2021-11-05
SHANGHAI INSTITUTE OF TECHNOLOGY
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, clinical trials have shown that long-term use of existing drugs may cause adverse reactions such as nausea, anorexia, and vomiting, and the curative effect is average, so it is not suitable for long-term use

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • White mustard seed extract as well as preparation method and application thereof
  • White mustard seed extract as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] Preparation of white mustard seed extract:

[0025] Sinapis alba: the Sinapis alba L. used in the present invention was purchased from Anqing, Anhui Province, and was identified as the dried mature seeds of Sinapis alba L., a cruciferous plant.

[0026] Extraction and separation of white mustard seed extract: soak and extract white mustard seed with ethanol with a volume fraction of 80%. After leaching for 60 minutes according to the volume ratio of solid to liquid at 1:12, reflux extraction for 120 minutes at an extraction temperature of 70° C. After concentrating and recovering ethanol under reduced pressure, the ethanol extract was obtained, then dissolved in water, extracted three times with ethyl acetate, the extracts were combined, and the solvent was recovered under pressure to obtain the ethyl acetate extract, which is the white mustard extract. Generally speaking, the yield of white mustard seed extraction is generally 1.3-1.7%.

[0027] Preliminary identifica...

Embodiment 1

[0054] Mix white mustard seed extract and starch slurry at a mass ratio of 1:1, pass through a 80-mesh sieve, mix well, add 10% starch slurry, pass through a 14-mesh sieve to granulate, and dry at 52°C until the moisture content is less than 1% , the dry granules are granulated through a 16-mesh sieve. The prepared dry granule is added with 3% magnesium stearate, mixed evenly, compressed into tablets, and the weight of each tablet is controlled to be 0.2g, and the tablets of the white mustard seed extract are obtained.

Embodiment 2

[0056] Vacuum-dry the white mustard extract and make it into powder, mix the white mustard extract and starch in a mass ratio of 2:1, add 0.5% magnesium stearate by total weight, fill it with hard capsules, and control the filling amount At 0.2-0.3g, the capsule of the white mustard seed extract is obtained.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a white mustard seed extract as well as a preparation method and application thereof. The preparation method comprises the following steps: extracting white mustard seeds with ethanol, removing ethanol to obtain an ethanol extract, adding water into the ethanol extract, performing dissolving, performing extracting with ethyl acetate, and removing an ethyl acetate solvent to obtain the white mustard seed extract. The extract is applied to preparation of an acetylcholin esterase inhibitor, and the inhibitor is a capsule, a tablet or a particle. Compared with the prior art, the white mustard seed extract disclosed by the invention is extracted from common spices, can be taken for a long time, and has small side effects compared with conventional treatment medicines. The strong inhibitory ability of the white mustard seed extract on the acetylcholin esterase provides a new idea for developing new treatment of senile dementia.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a white mustard seed extract and its preparation method and application. Background technique [0002] Alzheimer's disease, commonly known as "senile dementia", is a disease of the nervous system in the elderly. The clinical manifestations are deteriorating cognitive and memory functions, and the normal life of severe elderly people. In recent years, the number of AD patients in the world has increased exponentially, which has brought huge economic pressure and social burden to patients' families and public medical care. It is a research hotspot in today's world medical care. The main theory about the pathogenesis of Alzheimer's is the "cholinergic theory". Acetylcholine is a neurotransmitter that transmits signals between neurons. Once the acetylcholine in the patient's brain is released into the gap, it is immediately hydrolyzed by acetylcholinesterase, resulting in the loss of the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/31A61K9/20A61K9/48A61K9/16A61K47/36A61P25/28
CPCA61K36/31A61K9/2059A61K9/4866A61K9/1652A61K47/36A61P25/28A61K2236/33
Inventor 方向张赟彬冯奇许静
Owner SHANGHAI INSTITUTE OF TECHNOLOGY