Preparation method and application of anti-infection composite-layer medical dressing
A composite layer, anti-infection technology, applied in dressings, pharmaceutical formulations, adhesive dressings, etc., can solve problems such as poor skin fit, unfavorable wound healing, skin damage, etc., achieving simple and easy operation, excellent antibacterial and anti-infection, The effect of improving the film formability
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[0028] A preparation method for an anti-infection composite layer medical dressing, comprising the following specific steps:
[0029] Step 1, preparation of spinning solution: silk fibroin is dissolved in formic acid, and the concentration of the prepared silk fibroin solution is 10wt%; chitosan and polyethylene oxide (7:3) are dissolved in 70% glacial acetic acid, and the prepared 4wt% spinning solution;
[0030] Step 2, electrospinning double-layer nanofiber membrane: firstly carry out the electrospinning of the silk fibroin layer, after drying, directly carry out the electrospinning of the chitosan / polyoxyethylene layer on the silk fibroin layer to obtain the double-layer nanofiber film Fibrous film; the spinning condition of electrospinning technology is: the spinning condition in the described electrospinning technology is: voltage is 15-20kV, and spinneret tip is 15-20cm apart from receiver distance, and the flow velocity of syringe pump is in 0.5-1mL / h, continuous spin...
Embodiment 1
[0033] Preparation of silk fibroin fiber membrane: mix 1g silk fibroin with 9g formic acid, halve it at room temperature for 12 hours to prepare a 10wt% silk fibroin solution, which is mixed system A, and prepare a comforting membrane by electrospinning technology. The relative humidity is 40%±5%, the temperature is 25°C±5°C, the voltage is 20kV, the distance between the spinneret tip and the receiver is 20cm, and the flow rate of the syringe pump is continuously spun for 8h under the condition of 1mL / h. The aluminum foil was peeled off, and placed in a drying oven to dry to obtain a silk fibroin nanofiber layer.
Embodiment 2
[0035] Preparation of chitosan / polyethylene oxide nanofiber layer: Dissolve 0.28g of chitosan in 70wt% glacial acetic acid solution, add 0.12g of polyoxyethylene, stir at room temperature for 12h to form a uniform mixed solution, as Hybrid system B, using electrospinning technology to prepare composite membranes, at a relative humidity of 40%±5%, a temperature of 25°C±5°C, a voltage of 20kV, a distance of 20cm from the spinneret tip to the receiver, and a flow rate of the syringe pump at 1mL / h under the condition of continuous spinning for 8h, it was peeled off from the aluminum foil, and placed in a drying oven to dry to obtain the chitosan / polyoxyethylene nanofiber layer.
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